1.
Org Lett
; 2(3): 401-2, 2000 Feb 10.
Article
in English
| MEDLINE
| ID: mdl-10814333
ABSTRACT
[reaction: see text] The effect of chiral substituents on the enamide nitrogen atom upon the diastereoselection of the Mn(III)-mediated 4-exo-trig cyclization to beta-lactams was studied. A significant level of diastereoselectivity was achieved when an amino acid ester moiety was included into the enamidic skeleton. The structure of the major diastereoisomer was suggested by semiempirical calculations.