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Diagnostic Accuracy of QuantiFERON-TB Gold Plus Assays in Children and Adolescents with Tuberculosis Disease.

Soler-Garcia, Aleix; Gamell, Anna; Santiago, Begoña; Monsonís, Manuel; Calvo, Cristina; Cobo, Elvira; Colino, Elena; Espiau, María; Guerrero-Laleona, Carmelo; Lobato, Zulema; Martín-Nalda, Andrea; Pérez-Gorricho, Beatriz; Perez-Porcuna, Tomas M; Piqueras, Ana Isabel; Rodríguez-Molino, Paula; Ruiz, Marta; Soriano-Arandes, Antoni; Valmanya, Teresa; Tebruegge, Marc; Noguera-Julian, Antoni.

J Pediatr ; 223: 212-215.e1, 2020 08.

Article in English | MEDLINE | ID: mdl-32334890

ABSTRACT

In 2016, a new interferon-gamma release assay, QuantiFERON-TB Gold Plus, was introduced. We conducted a cross-sectional multicenter study, involving 158 children and adolescents with tuberculosis disease. The overall sensitivity of the assay was 82.9% (IQR 77.0%-88.8%), indicating that in children this test does not have higher sensitivity than previous generation interferon-gamma release assays.

Subject(s)

Interferon-gamma Release Tests/methods , Mycobacterium tuberculosis/isolation & purification , Tuberculosis/diagnosis , Adolescent , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Male , Retrospective Studies , Tuberculin Test/methods , Tuberculosis/microbiology

ABSTRACT

Subject(s)

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