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Gan To Kagaku Ryoho ; 50(13): 1447-1449, 2023 Dec.
Article in Japanese | MEDLINE | ID: mdl-38303303

ABSTRACT

A 57-year-old man was diagnosed as having resectable advanced esophageal carcinoma adjacent to the trachea(Ut, cT3N0M0)and received preoperative docetaxel, cisplatin, and 5-fluorouracil therapy. Due to tracheal tumor invasion and upstaging to cT4bN0M0 after 1 course of chemotherapy, the treatment was converted to definitive chemoradiotherapy (CRT). A remarkable response with no evidence of tracheal invasion was observed on computed tomography following definitive CRT. He underwent successful curative resection with salvage esophagectomy, and the resected tumor was staged as pT1bN0M0. No adjuvant therapy was administered, and the patient was alive with no evidence of disease at the 5-year postoperative follow-up. The response to preoperative treatment should be meticulously assessed and appropriate treatment modalities used to avoid overlooking the potential for cure, even if the response to preoperative treatment with docetaxel, cisplatin, and 5-fluorouracil is poor.


Subject(s)
Carcinoma , Esophageal Neoplasms , Male , Humans , Middle Aged , Cisplatin , Docetaxel/therapeutic use , Fluorouracil , Trachea/pathology , Esophagectomy , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Esophageal Neoplasms/drug therapy , Chemoradiotherapy , Carcinoma/drug therapy , Treatment Outcome
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