Search details
1.
Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR.
J Biol Chem
; 300(2): 105650, 2024 Feb.
Article
in English
| MEDLINE | ID: mdl-38237681
2.
Deficits in Behavioral and Neuronal Pattern Separation in Temporal Lobe Epilepsy.
J Neurosci
; 41(46): 9669-9686, 2021 11 17.
Article
in English
| MEDLINE | ID: mdl-34620720
3.
Sleep Deprivation Exacerbates Seizures and Diminishes GABAergic Tonic Inhibition.
Ann Neurol
; 90(5): 840-844, 2021 11.
Article
in English
| MEDLINE | ID: mdl-34476841
4.
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models.
Nature
; 539(7627): 107-111, 2016 11 03.
Article
in English
| MEDLINE | ID: mdl-27595393
5.
Targeting renal cell carcinoma with a HIF-2 antagonist.
Nature
; 539(7627): 112-117, 2016 11 03.
Article
in English
| MEDLINE | ID: mdl-27595394
6.
Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension.
Eur Respir J
; 57(3)2021 03.
Article
in English
| MEDLINE | ID: mdl-32972983
7.
Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.
Bioorg Med Chem
; 28(1): 115232, 2020 01 01.
Article
in English
| MEDLINE | ID: mdl-31818630
8.
Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension.
Eur Respir J
; 54(6)2019 12.
Article
in English
| MEDLINE | ID: mdl-31515405
9.
Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy.
Epilepsia
; 59(8): 1527-1539, 2018 08.
Article
in English
| MEDLINE | ID: mdl-30009381
10.
Seizure phenotypes, periodicity, and sleep-wake pattern of seizures in Kcna-1 null mice.
Epilepsy Behav
; 55: 24-9, 2016 Feb.
Article
in English
| MEDLINE | ID: mdl-26724401
11.
Single-agent inhibition of Chk1 is antiproliferative in human cancer cell lines in vitro and inhibits tumor xenograft growth in vivo.
Oncol Res
; 19(7): 349-63, 2011.
Article
in English
| MEDLINE | ID: mdl-21936404
12.
Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.
Bioorg Med Chem Lett
; 21(8): 2335-40, 2011 Apr 15.
Article
in English
| MEDLINE | ID: mdl-21420856
13.
Sleep-wake characteristics in a mouse model of severe traumatic brain injury: Relation to posttraumatic epilepsy.
Epilepsia Open
; 6(1): 181-194, 2021 03.
Article
in English
| MEDLINE | ID: mdl-33681661
14.
Sleep and diurnal rest-activity rhythm disturbances in a mouse model of Alzheimer's disease.
Sleep
; 43(11)2020 11 12.
Article
in English
| MEDLINE | ID: mdl-32369586
15.
Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820.
Structure
; 27(11): 1625-1633.e3, 2019 11 05.
Article
in English
| MEDLINE | ID: mdl-31693911
16.
Histone deacetylase inhibitors restore normal hippocampal synaptic plasticity and seizure threshold in a mouse model of Tuberous Sclerosis Complex.
Sci Rep
; 9(1): 5266, 2019 03 27.
Article
in English
| MEDLINE | ID: mdl-30918308
17.
A systems approach identifies Enhancer of Zeste Homolog 2 (EZH2) as a protective factor in epilepsy.
PLoS One
; 14(12): e0226733, 2019.
Article
in English
| MEDLINE | ID: mdl-31891591
18.
3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma.
J Med Chem
; 62(15): 6876-6893, 2019 08 08.
Article
in English
| MEDLINE | ID: mdl-31282155
19.
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor.
Clin Cancer Res
; 13(5): 1576-83, 2007 Mar 01.
Article
in English
| MEDLINE | ID: mdl-17332304
20.
A predictive epilepsy index based on probabilistic classification of interictal spike waveforms.
PLoS One
; 13(11): e0207158, 2018.
Article
in English
| MEDLINE | ID: mdl-30399183