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1.
Evaluating the efficacy of the selective orexin 1 receptor antagonist nivasorexant in an animal model of binge-eating disorder.
Int J Eat Disord
; 2024 Mar 08.
Article
in English
| MEDLINE | ID: mdl-38456603
2.
The metabolism of the orexin-1 selective receptor antagonist nivasorexant.
Xenobiotica
; 54(3): 124-137, 2024 Mar.
Article
in English
| MEDLINE | ID: mdl-38358311
3.
Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2.
Bioorg Med Chem Lett
; 25(9): 1884-91, 2015 May 01.
Article
in English
| MEDLINE | ID: mdl-25838147
4.
Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1.
Bioorg Med Chem Lett
; 24(4): 1201-8, 2014 Feb 15.
Article
in English
| MEDLINE | ID: mdl-24447850
5.
Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure-activity-relationship, and sleep-promoting properties in rats.
RSC Med Chem
; 15(1): 344-354, 2024 Jan 25.
Article
in English
| MEDLINE | ID: mdl-38283232
6.
Discovery of Nivasorexant (ACT-539313): The First Selective Orexin-1 Receptor Antagonist (SO1RA) Investigated in Clinical Trials.
J Med Chem
; 67(4): 2337-2348, 2024 Feb 22.
Article
in English
| MEDLINE | ID: mdl-38331429
7.
Discovery of a Novel Orally Active, Selective LPA Receptor Type 1 Antagonist, 4-(4-(2-Isopropylphenyl)-4-((2-methoxy-4-methylphenyl)carbamoyl)piperidin-1-yl)-4-oxobutanoic Acid, with a Distinct Molecular Scaffold.
J Med Chem
; 67(4): 2379-2396, 2024 Feb 22.
Article
in English
| MEDLINE | ID: mdl-38349223
8.
A uniquely efficacious type of CFTR corrector with complementary mode of action.
Sci Adv
; 10(9): eadk1814, 2024 Mar.
Article
in English
| MEDLINE | ID: mdl-38427726
9.
The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders.
ChemMedChem
; 15(23): 2286-2305, 2020 12 03.
Article
in English
| MEDLINE | ID: mdl-32937014
10.
From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved inâ vivo Efficacy in Dogs.
ChemMedChem
; 15(5): 430-448, 2020 03 05.
Article
in English
| MEDLINE | ID: mdl-31945272
11.
Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in Rats.
ChemMedChem
; 14(13): 1257-1270, 2019 07 03.
Article
in English
| MEDLINE | ID: mdl-31066976
12.
Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach.
ChemMedChem
; 11(19): 2132-2146, 2016 10 06.
Article
in English
| MEDLINE | ID: mdl-27390287
13.
Synthesis of 3,4-disubstituted piperidines by carbonyl ene and Prins cyclizations: a switch in diastereoselectivity between Lewis and Brønsted acid catalysts.
Org Lett
; 4(21): 3727-30, 2002 Oct 17.
Article
in English
| MEDLINE | ID: mdl-12375929
14.
Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist.
ChemMedChem
; 9(11): 2486-96, 2014 Nov.
Article
in English
| MEDLINE | ID: mdl-25147058
15.
Stereoselective synthesis of 3,4-disubstituted and 3,4,5-trisubstituted piperidines by Lewis acid-catalysed ene cyclisation of 4-aza-1,7-dienes.
Org Biomol Chem
; 5(18): 2925-31, 2007 Sep 21.
Article
in English
| MEDLINE | ID: mdl-17728858
16.
Synthesis of 3,4-disubstituted piperidines by carbonyl ene and prins cyclizations: switching between kinetic and thermodynamic control with Brønsted and Lewis acid catalysts.
J Org Chem
; 71(6): 2460-71, 2006 Mar 17.
Article
in English
| MEDLINE | ID: mdl-16526798
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