Search | Virtual Health Library

1.

Sequence elements within the PEXEL motif and its downstream region modulate PTEX-dependent protein export in Plasmodium falciparum.

Gabriela, Mikha; Barnes, Claudia B G; Leong, Dickson; Sleebs, Brad E; Schneider, Molly Parkyn; Littler, Dene R; Crabb, Brendan S; de Koning-Ward, Tania F; Gilson, Paul R.

Traffic ; 25(1): e12922, 2024 01.

Article in English | MEDLINE | ID: mdl-37926971

2.

Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics.

Dans, Madeline G; Piirainen, Henni; Nguyen, William; Khurana, Sachin; Mehra, Somya; Razook, Zahra; Geoghegan, Niall D; Dawson, Aurelie T; Das, Sujaan; Parkyn Schneider, Molly; Jonsdottir, Thorey K; Gabriela, Mikha; Gancheva, Maria R; Tonkin, Christopher J; Mollard, Vanessa; Goodman, Christopher Dean; McFadden, Geoffrey I; Wilson, Danny W; Rogers, Kelly L; Barry, Alyssa E; Crabb, Brendan S; de Koning-Ward, Tania F; Sleebs, Brad E; Kursula, Inari; Gilson, Paul R.

PLoS Biol ; 21(4): e3002066, 2023 04.

Article in English | MEDLINE | ID: mdl-37053271

3.

A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell.

Gabriela, Mikha; Matthews, Kathryn M; Boshoven, Cas; Kouskousis, Betty; Jonsdottir, Thorey K; Bullen, Hayley E; Modak, Joyanta; Steer, David L; Sleebs, Brad E; Crabb, Brendan S; de Koning-Ward, Tania F; Gilson, Paul R.

PLoS Pathog ; 18(2): e1009977, 2022 02.

Article in English | MEDLINE | ID: mdl-35192672

4.

The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture.

Bullen, Hayley E; Sanders, Paul R; Dans, Madeline G; Jonsdottir, Thorey K; Riglar, David T; Looker, Oliver; Palmer, Catherine S; Kouskousis, Betty; Charnaud, Sarah C; Triglia, Tony; Gabriela, Mikha; Parkyn Schneider, Molly; Chan, Jo-Anne; de Koning-Ward, Tania F; Baum, Jake; Kazura, James W; Beeson, James G; Cowman, Alan F; Gilson, Paul R; Crabb, Brendan S.

Mol Microbiol ; 117(5): 1245-1262, 2022 05.

Article in English | MEDLINE | ID: mdl-35403274

5.

Altered gastrointestinal tract structure and microbiome following cerebral malaria infection.

Knowler, Sarah A; Shindler, Anya; Wood, Jennifer L; Lakkavaram, Asha; Thomas, Colleen J; de Koning-Ward, Tania F; Hill-Yardin, Elisa L; Carvalho, Teresa G; Franks, Ashley E.

Parasitol Res ; 122(3): 789-799, 2023 Mar.

Article in English | MEDLINE | ID: mdl-36602586

6.

Molecular approaches to Malaria 2020.

de Koning-Ward, Tania F; Boddey, Justin A; Fowkes, Freya J I.

Cell Microbiol ; 23(3): e13289, 2021 03.

Article in English | MEDLINE | ID: mdl-33197142

7.

Characterisation of complexes formed by parasite proteins exported into the host cell compartment of Plasmodium falciparum infected red blood cells.

Jonsdottir, Thorey K; Counihan, Natalie A; Modak, Joyanta K; Kouskousis, Betty; Sanders, Paul R; Gabriela, Mikha; Bullen, Hayley E; Crabb, Brendan S; de Koning-Ward, Tania F; Gilson, Paul R.

Cell Microbiol ; 23(8): e13332, 2021 08.

Article in English | MEDLINE | ID: mdl-33774908

8.

Illuminating how malaria parasites export proteins into host erythrocytes.

Matthews, Kathryn M; Pitman, Ethan L; de Koning-Ward, Tania F.

Cell Microbiol ; 21(4): e13009, 2019 04.

Article in English | MEDLINE | ID: mdl-30656810

9.

PTEX is an essential nexus for protein export in malaria parasites.

Elsworth, Brendan; Matthews, Kathryn; Nie, Catherine Q; Kalanon, Ming; Charnaud, Sarah C; Sanders, Paul R; Chisholm, Scott A; Counihan, Natalie A; Shaw, Philip J; Pino, Paco; Chan, Jo-Anne; Azevedo, Mauro F; Rogerson, Stephen J; Beeson, James G; Crabb, Brendan S; Gilson, Paul R; de Koning-Ward, Tania F.

Nature ; 511(7511): 587-91, 2014 Jul 31.

Article in English | MEDLINE | ID: mdl-25043043

10.

The malaria parasite Plasmodium falciparum Sortilin is essential for merozoite formation and apical complex biogenesis.

Hallée, Stéphanie; Counihan, Natalie A; Matthews, Kathryn; de Koning-Ward, Tania F; Richard, Dave.

Cell Microbiol ; 20(8): e12844, 2018 08.

Article in English | MEDLINE | ID: mdl-29582546

11.

Development of a Novel CD4⁺ TCR Transgenic Line That Reveals a Dominant Role for CD8⁺ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria.

Fernandez-Ruiz, Daniel; Lau, Lei Shong; Ghazanfari, Nazanin; Jones, Claerwen M; Ng, Wei Yi; Davey, Gayle M; Berthold, Dorothee; Holz, Lauren; Kato, Yu; Enders, Matthias H; Bayarsaikhan, Ganchimeg; Hendriks, Sanne H; Lansink, Lianne I M; Engel, Jessica A; Soon, Megan S F; James, Kylie R; Cozijnsen, Anton; Mollard, Vanessa; Uboldi, Alessandro D; Tonkin, Christopher J; de Koning-Ward, Tania F; Gilson, Paul R; Kaisho, Tsuneyasu; Haque, Ashraful; Crabb, Brendan S; Carbone, Francis R; McFadden, Geoffrey I; Heath, William R.

J Immunol ; 199(12): 4165-4179, 2017 12 15.

Article in English | MEDLINE | ID: mdl-29084838

12.

Spotlight on proteins that aid malaria.

de Koning-Ward, Tania F.

Nature ; 561(7721): 41-43, 2018 09.

Article in English | MEDLINE | ID: mdl-30181625

13.

Plasmodium falciparum Nucleosomes Exhibit Reduced Stability and Lost Sequence Dependent Nucleosome Positioning.

Silberhorn, Elisabeth; Schwartz, Uwe; Löffler, Patrick; Schmitz, Samuel; Symelka, Anne; de Koning-Ward, Tania; Merkl, Rainer; Längst, Gernot.

PLoS Pathog ; 12(12): e1006080, 2016 Dec.

Article in English | MEDLINE | ID: mdl-28033404

14.

The Plasmodium rhoptry associated protein complex is important for parasitophorous vacuole membrane structure and intraerythrocytic parasite growth.

Ghosh, Sreejoyee; Kennedy, Kit; Sanders, Paul; Matthews, Kathryn; Ralph, Stuart A; Counihan, Natalie A; de Koning-Ward, Tania F.

Cell Microbiol ; 19(8)2017 08.

Article in English | MEDLINE | ID: mdl-28205319

15.

The Plasmodium translocon of exported proteins component EXP2 is critical for establishing a patent malaria infection in mice.

Kalanon, Ming; Bargieri, Daniel; Sturm, Angelika; Matthews, Kathryn; Ghosh, Sreejoyee; Goodman, Christopher D; Thiberge, Sabine; Mollard, Vanessa; McFadden, Geoffrey I; Ménard, Robert; de Koning-Ward, Tania F.

Cell Microbiol ; 18(3): 399-412, 2016 Mar.

Article in English | MEDLINE | ID: mdl-26347246

16.

Proteomic analysis reveals novel proteins associated with the Plasmodium protein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150.

Elsworth, Brendan; Sanders, Paul R; Nebl, Thomas; Batinovic, Steven; Kalanon, Ming; Nie, Catherine Q; Charnaud, Sarah C; Bullen, Hayley E; de Koning Ward, Tania F; Tilley, Leann; Crabb, Brendan S; Gilson, Paul R.

Cell Microbiol ; 18(11): 1551-1569, 2016 Nov.

Article in English | MEDLINE | ID: mdl-27019089

17.

CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria.

Lau, Lei Shong; Fernandez-Ruiz, Daniel; Mollard, Vanessa; Sturm, Angelika; Neller, Michelle A; Cozijnsen, Anton; Gregory, Julia L; Davey, Gayle M; Jones, Claerwen M; Lin, Yi-Hsuan; Haque, Ashraful; Engwerda, Christian R; Nie, Catherine Q; Hansen, Diana S; Murphy, Kenneth M; Papenfuss, Anthony T; Miles, John J; Burrows, Scott R; de Koning-Ward, Tania; McFadden, Geoffrey I; Carbone, Francis R; Crabb, Brendan S; Heath, William R.

PLoS Pathog ; 10(5): e1004135, 2014 May.

Article in English | MEDLINE | ID: mdl-24854165

18.

An aspartyl protease directs malaria effector proteins to the host cell.

Boddey, Justin A; Hodder, Anthony N; Günther, Svenja; Gilson, Paul R; Patsiouras, Heather; Kapp, Eugene A; Pearce, J Andrew; de Koning-Ward, Tania F; Simpson, Richard J; Crabb, Brendan S; Cowman, Alan F.

Nature ; 463(7281): 627-31, 2010 Feb 04.

Article in English | MEDLINE | ID: mdl-20130643

19.

A newly discovered protein export machine in malaria parasites.

de Koning-Ward, Tania F; Gilson, Paul R; Boddey, Justin A; Rug, Melanie; Smith, Brian J; Papenfuss, Anthony T; Sanders, Paul R; Lundie, Rachel J; Maier, Alexander G; Cowman, Alan F; Crabb, Brendan S.

Nature ; 459(7249): 945-9, 2009 Jun 18.

Article in English | MEDLINE | ID: mdl-19536257

20.

The Plasmodium translocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth.

Matthews, Kathryn; Kalanon, Ming; Chisholm, Scott A; Sturm, Angelika; Goodman, Christopher D; Dixon, Matthew W A; Sanders, Paul R; Nebl, Thomas; Fraser, Fiona; Haase, Silvia; McFadden, Geoffrey I; Gilson, Paul R; Crabb, Brendan S; de Koning-Ward, Tania F.

Mol Microbiol ; 89(6): 1167-86, 2013 Sep.

Article in English | MEDLINE | ID: mdl-23869529

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