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Anaerobe ; 18(3): 363-5, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22306065

ABSTRACT

In this work, we produced and evaluated a vaccine based on a ß toxoid of Clostridium perfringens type C produced in Escherichia coli (rBT). The non-toxic rBT was innocuous for mice and induced 14 IU mL(-1) of ß antitoxin in rabbits, complying with the European Pharmacopeia and CFR9 - USDA guidelines.


Subject(s)
Bacterial Vaccines/biosynthesis , Clostridium perfringens/immunology , Toxoids/biosynthesis , Vaccines, Synthetic/biosynthesis , Animals , Bacterial Toxins/genetics , Bacterial Vaccines/genetics , Bacterial Vaccines/toxicity , Escherichia coli , Mice , Mice, Inbred BALB C , Rabbits , Toxoids/genetics , Toxoids/toxicity , Vaccination , Vaccines, Synthetic/genetics , Vaccines, Synthetic/toxicity
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