Characterization of the vertical evolution of the three-dimensional turbulence for fatigue design of tidal turbines.

A system of two coupled four-beam acoustic Doppler current profilers was used to collect turbulence measurements over a 36-h period at a highly energetic tidal energy site in Alderney Race. This system enables the evaluation of the six components of the Reynolds stress tensor throughout a large proportion of the water column. The present study provides mean vertical profiles of the velocity, the turbulence intensity and the integral lengthscale along the streamwise, spanwise and vertical direction of the tidal current. Based on our results and considering a tidal-stream energy convertor (TEC) aligned with the current main direction, the main elements of turbulence prone to affect the structure (material fatigue) and to alter power generation would likely be: (i) the streamwise turbulence intensity (Ix), (ii) the shear stress, [Formula: see text], (iii) the normal stress, [Formula: see text] and (iv) the vertical integral lengthscale (Lz). The streamwise turbulence intensity, (Ix), was found to be higher than that estimated at other tidal energy sites across the world for similar height above bottom. Along the vertical direction, the length (Lz) of the large-scale turbulence eddies was found to be equivalent to the rotor diameter of the TEC Sabella D10. It is considered that the turbulence metrics presented in this paper will be valuable for TECs designers, helping them optimize their designs as well as improve loading prediction through the lifetime of the machines. This article is part of the theme issue 'New insights on tidal dynamics and tidal energy harvesting in the Alderney Race'.

Field measurements of turbulent mixing south of the Lombok Strait, Indonesia.

The Indonesian seas, with their complex passages and vigorous mixing, constitute the only route and are critical in regulating Pacific-Indian Ocean interchange, air-sea interaction, and global climate events. Previous research employing remote sensing and numerical simulations strongly suggested that this mixing is tidally driven and localized in narrow channels and straits, with only a few direct observations to validate it. The current study offers the first comprehensive temporal microstructure observations in the south of Lombok Strait with a radius of 0.05° and centered on 115.54oE and 9.02oS. Fifteen days of tidal mixing observations measured potential temperature and density, salinity, and turbulent energy dissipation rate. The results revealed significant mixing and verified the remotely sensed technique. The south Lombok temporal and depth averaged of the turbulent kinetic energy dissipation rate, and the diapycnal diffusivity from 20 to 250 m are ε  = 4.15 ± 15.9) × 10-6 W kg-1 and K ρ = (1.44 ± 10.7) × 10-2 m2s-1, respectively. This K ρ is up to 104 times larger than the Banda Sea [ K ρ  = (9.2 ± 0.55) × 10-6 m2s-1] (Alford et al. Geophys Res Lett 26:2741-2744, 1999) or the "open ocean" K ρ = 0.03 × 10-4 m2s-1 within 2° of the equator to (0.4-0.5) × 10-4 m2s-1 at 50°-70° (Kunze et al. J Phys Oceanogr 36:1553-1576, 2006). Therefore, nonlinear interactions between internal tides, tidally induced mixing, and ITF plays a critical role regulating water mass transformation and have strong implications to longer-term variations and change of Pacific-Indian Ocean water circulation and climate. Supplementary Information: The online version contains supplementary material available at 10.1186/s40562-024-00349-3.

In Silico Methods for Chromosome Damage.

Due to the link with serious adverse health effects, genotoxicity is an important toxicological endpoint in each regulatory setting with respect to human health, including for pharmaceuticals. To this extent, a compound potential to induce gene mutations as well as chromosome damage needs to be addressed. For chromosome damage, i.e., the induction of structural or numerical chromosome aberrations, several in vitro and in vivo test methods are available. In order to rapidly collect toxicological data without the need for test material, several in silico tools for chromosome damage have been developed over the last years. In this chapter, a battery of freely available in silico chromosome damage prediction tools for chromosome damage is applied on a dataset of pharmaceuticals. Examples of the different outcomes obtained with the in silico battery are provided and briefly discussed. Furthermore, results for coumarin are presented in more detail as a case study. Overall, it can be concluded that although they are in general less developed than those for mutagenicity, in silico tools for chromosome damage can provide valuable information, especially when combined in a battery.

Current status and future directions for a neurotoxicity hazard assessment framework that integrates in silico approaches.

Neurotoxicology is the study of adverse effects on the structure or function of the developing or mature adult nervous system following exposure to chemical, biological, or physical agents. The development of more informative alternative methods to assess developmental (DNT) and adult (NT) neurotoxicity induced by xenobiotics is critically needed. The use of such alternative methods including in silico approaches that predict DNT or NT from chemical structure (e.g., statistical-based and expert rule-based systems) is ideally based on a comprehensive understanding of the relevant biological mechanisms. This paper discusses known mechanisms alongside the current state of the art in DNT/NT testing. In silico approaches available today that support the assessment of neurotoxicity based on knowledge of chemical structure are reviewed, and a conceptual framework for the integration of in silico methods with experimental information is presented. Establishing this framework is essential for the development of protocols, namely standardized approaches, to ensure that assessments of NT and DNT based on chemical structures are generated in a transparent, consistent, and defendable manner.