A Lightweight Algorithm to Model Radiation Damage Effects in Monte Carlo Events for High-Luminosity Large Hadron Collider Experiments.

Radiation damage significantly impacts the performance of silicon tracking detectors in Large Hadron Collider (LHC) experiments such as ATLAS and CMS, with signal reduction being the most critical effect; adjusting sensor bias voltage and detection thresholds can help mitigate these effects, generating simulated data that accurately mirror the performance evolution with the accumulation of luminosity, hence fluence, is crucial. The ATLAS and CMS collaborations have developed and implemented algorithms to correct simulated Monte Carlo (MC) events for radiation damage effects, achieving impressive agreement between collision data and simulated events. In preparation for the high-luminosity phase (HL-LHC), the demand for a faster ATLAS MC production algorithm becomes imperative due to escalating collision, events, tracks, and particle hit rates, imposing stringent constraints on available computing resources. This article outlines the philosophy behind the new algorithm, its implementation strategy, and the essential components involved. The results from closure tests indicate that the events simulated using the new algorithm agree with fully simulated events at the level of few %. The first tests on computing performance show that the new algorithm is as fast as it is when no radiation damage corrections are applied.

Modular and Cost-Effective Computed Tomography Design.

We present a modular and cost-effective gamma ray computed tomography system for multiphase flow investigations in industrial apparatuses. It mainly comprises a 137Cs isotopic source and an in-house-assembled detector arc, with a total of 16 scintillation detectors, offering a quantum efficiency of approximately 75% and an active area of 10 × 10 mm2 each. The detectors are operated in pulse mode to exclude scattered gamma photons from counting by using a dual-energy discrimination stage. Flexible application of the computed tomography system, i.e., for various object sizes and densities, is provided by an elaborated detector arc design, in combination with a scanning procedure that allows for simultaneous parallel beam projection acquisition. This allows the scan time to be scaled down with the number of individual detectors. Eventually, the developed scanner successfully upgrades the existing tomography setup in the industry. Here, single pencil beam gamma ray computed tomography is already used to study hydraulics in gas-liquid contactors, with inner diameters of up to 440 mm. We demonstrate the functionality of the new system for radiographic and computed tomographic scans of DN110 and DN440 columns that are operated at varying iso-hexane/nitrogen liquid-gas flow rates.

Direct Fast-Neutron Detection by 2D Perovskite Semiconductor.

Fast-neutrons play a critical role in a range of applications, including medical imaging, therapy, and nondestructive inspection. However, direct detecting fast-neutrons by semiconductors has proven to be challenging due to their weak interaction with most matter and the requirement of high carrier mobility-lifetime (µτ) product for efficient charge collection. Herein, a novel approach is presented to direct fast-neutron detection using 2D Dion-Jacobson perovskite semiconductor BDAPbBr4 . This material features a high fast-neutron caption cross-section, good electrical stability, high resistivity, and, most importantly, a record-high µτ product of 3.3 × 10-4 cm2 V-1 , outperforming most reported fast-neutron detection semiconductors. As a result, BDAPbBr4 detector exhibited good response to fast-neutrons, not only achieving fast-neutron energy spectra in counting mode, but also obtaining linear and fast response in integration mode. This work provides a paradigm-shifting strategy for designing materials that efficiently detect fast-neutrons and paves the way toward exciting applications in fast-neutron imaging and therapy.

Advances in High-Energy-Resolution CdZnTe Linear Array Pixel Detectors with Fast and Low Noise Readout Electronics.

Radiation detectors based on Cadmium Zinc Telluride (CZT) compounds are becoming popular solutions thanks to their high detection efficiency, room temperature operation, and to their reliability in compact detection systems for medical, astrophysical, or industrial applications. However, despite a huge effort to improve the technological process, CZT detectors' full potential has not been completely exploited when both high spatial and energy resolution are required by the application, especially at low energies (<10 keV), limiting their application in energy-resolved photon counting (ERPC) systems. This gap can also be attributed to the lack of dedicated front-end electronics which can bring out the best in terms of detector spectroscopic performances. In this work, we present the latest results achieved in terms of energy resolution using SIRIO, a fast low-noise charge sensitive amplifier, and a linear-array pixel detector, based on boron oxide encapsulated vertical Bridgman-grown B-VB CZT crystals. The detector features a 0.25-mm pitch, a 1-mm thickness and is operated at a -700-V bias voltage. An equivalent noise charge of 39.2 el. r.m.s. (corresponding to 412 eV FWHM) was measured on the test pulser at 32 ns peaking time, leading to a raw resolution of 1.3% (782 eV FWHM) on the 59 keV line at room temperature (+20 °C) using an uncollimated 241Am, largely improving the current state of the art for CZT-based detection systems at such short peaking times, and achieving an optimum resolution of 0.97% (576 eV FWHM) at 1 µs peaking time. The measured energy resolution at the 122 keV line and with 1 µs peaking time of a 57Co raw uncollimated spectrum is 0.96% (1.17 keV). These activities are in the framework of an Italian collaboration on the development of energy-resolved X-ray scanners for material recycling, medical applications, and non-destructive testing in the food industry.

A Novel Method to Model Image Creation Based on Mammographic Sensors Performance Parameters: A Theoretical Study.

BACKGROUND: Mammographic digital imaging is based on X-ray sensors with solid image quality characteristics. These primarily include (a) a response curve that yields high contrast and image latitude, (b) a frequency response given by the Modulation Transfer Function (MTF), which enables small detail imaging and (c) the Normalize Noise Power Spectrum (NNPS) that shows the extent of the noise effect on image clarity. METHODS: In this work, a methodological approach is introduced and described for creating digital phantom images based on the measured image quality properties of the sensor. For this purpose, a mathematical phantom, simulating breast tissue and lesions of blood, adipose, muscle, Ca and Ca(50%)-P(50%) was created by considering the corresponding X-ray attenuation coefficients. The simulated irradiation conditions of the phantom used four mammographic spectra assuming exponential attenuation. Published data regarding noise and blur of a commercial RadEye HR CMOS imaging sensor were used as input data for the resulting images. RESULTS: It was found that the Ca and Ca(50%)-P(50%) lesions were visible in all exposure conditions. In addition, the W/Rh spectrum at 28 kVp provided more detailed images than the corresponding Mo/Mo spectrum. CONCLUSIONS: The presented methodology can act complementarily to image quality measurements, leading to initial optimization of the X-ray exposure parameters per clinical condition.

Electric-Field Mapping of Optically Perturbed CdTe Radiation Detectors.

In radiation detectors, the spatial distribution of the electric field plays a fundamental role in their operation. Access to this field distribution is of strategic importance, especially when investigating the perturbing effects induced by incident radiation. For example, one dangerous effect that prevents their proper operation is the accumulation of internal space charge. Here, we probe the two-dimensional electric field in a Schottky CdTe detector using the Pockels effect and report on its local perturbation after exposure to an optical beam at the anode electrode. Our electro-optical imaging setup, together with a custom processing routine, allows the extraction of the electric-field vector maps and their dynamics during a voltage bias-optical exposure sequence. The results are in agreement with numerical simulations, allowing us to confirm a two-level model based on a dominant deep level. Such a simple model is indeed able to fully account for both the temporal and spatial dynamics of the perturbed electric field. This approach thus allows a deeper understanding of the main mechanisms affecting the non-equilibrium electric-field distribution in CdTe Schottky detectors, such as those leading to polarization. In the future, it could also be used to predict and improve the performance of planar or electrode-segmented detectors.

Bragg Curve Detection of Low-Energy Protons by Radiophotoluminescence Imaging in Lithium Fluoride Thin Films.

Lithium fluoride (LiF) crystals and thin films are utilized as radiation detectors for energy diagnostics of proton beams. This is achieved by analyzing the Bragg curves in LiF obtained by imaging the radiophotoluminescence of color centers created by protons. In LiF crystals, the Bragg peak depth increases superlinearly with the particle energy. A previous study has shown that, when 35 MeV protons impinge at grazing incidence onto LiF films deposited on Si(100) substrates, the Bragg peak in the films is located at the depth where it would be found in Si rather than in LiF due to multiple Coulomb scattering. In this paper, Monte Carlo simulations of proton irradiations in the 1-8 MeV energy range are performed and compared to experimental Bragg curves in optically transparent LiF films on Si(100) substrates. Our study focuses on this energy range because, as energy increases, the Bragg peak gradually shifts from the depth in LiF to that in Si. The impact of grazing incidence angle, LiF packing density, and film thickness on shaping the Bragg curve in the film is examined. At energies higher than 8 MeV, all these quantities must be considered, although the effect of packing density plays a minor role.

State-of-the-Art Room Temperature Operable Zero-Bias Schottky Diode-Based Terahertz Detector Up to 5.56 THz.

We present the characterization of a Zero-bias Schottky diode-based Terahertz (THz) detector up to 5.56 THz. The detector was operated with both a table-top system until 1.2 THz and at a Free-Electron Laser (FEL) facility at singular frequencies from 1.9 to 5.56 THz. We used two measurement techniques in order to discriminate the sub-ns-scale (via a 20 GHz oscilloscope) and the ms-scale (using the lock-in technique) responsivity. While the lock-in measurements basically contain all rectification effects, the sub-ns-scale detection with the oscilloscope is not sensitive to slow bolometric effects caused by changes of the IV characteristic due to temperature. The noise equivalent power (NEP) is 10 pW/Hz in the frequency range from 0.2 to 0.6 THz and 17 pW/Hz at 1.2 THz and increases to 0.9 µW/Hz at 5.56 THz, which is at the state of the art for room temperature zero-bias Schottky diode-based THz detectors with non-resonant antennas. The voltage and current responsivity of ∼500 kV/W and ∼100 mA/W, respectively, is demonstrated over a frequency range of 0.2 to 1.2 THz with the table-top system.

Optical Writing and Electro-Optic Imaging of Reversible Space Charges in Semi-Insulating CdTe Diodes.

Deep levels control the space charge in electrically compensated semi-insulating materials. They limit the performance of radiation detectors but their interaction with free carriers can be favorably exploited in these devices to manipulate the spatial distribution of the electric field by optical beams. By using semi-insulating CdTe diodes as a case study, our results show that optical doping functionalities are achieved. As such, a highly stable, flux-dependent, reversible and spatially localized space charge is induced by a line-shaped optical beam focused on the cathode contact area. Real-time non-invasive imaging of the electric field is obtained through the Pockels effect. A simple and convenient method to retrieve the two-dimensional electric field components is presented. Numerical simulations involving just one deep level responsible for the electrical compensation confirm the experimental findings and help to identify the underlying mechanism and critical parameters enabling the optical writing functionalities.

Design and Characterization of Backside Termination Structures for Thick Fully-Depleted MAPS.

Fully Depleted Monolithic Active Pixel Sensors (FD-MAPS) represent an appealing alternative to hybrid detectors for radiation imaging applications. We have recently demonstrated the feasibility of FD-MAPS based on a commercial 110 nm CMOS technology, adapted using high-resistivity substrates and backside post-processing. A p/n junction diode, fabricated on the detector backside using low-temperature processing steps after the completion of the front-side Back End of Line (BEOL), is reverse-biased to achieve the full depletion of the substrate and thus fast charge collection by drift. Test diodes including termination structures with different numbers of floating guard rings and different pitches were fabricated together with other Process Control Monitor structures. In this paper, we present the design of the backside diodes, together with results from the electrical characterization of the test devices, aiming to improve understanding of the strengths and limitations of the proposed approach. Characterization results obtained on several wafers demonstrate the effectiveness of the termination rings in increasing the breakdown voltage of the backside diodes and in coping with the variability of the passivation layer characteristics. A breakdown voltage exceeding 400 V in the worst case was demonstrated in devices with 30 guard rings with 6 µm pitch, thus enabling the full depletion of high-resistivity substrates with a thickness larger than or equal to 300 µm. Additionally, we show the first direct comparison for this technology of measured pixel characteristics with 3D TCAD simulations, proving a good agreement in the extracted operating voltages.

Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter.

A single crystal chemical vapor deposition (scCVD) diamond membrane-based microdosimetric system was used to perform simultaneous measurements of dose profile and microdosimetric spectra with the Y1 proton passive scattering beamline of the Center of Proton Therapy, Institute Curie in Orsay, France. To qualify the performance of the set-up in clinical conditions of hadrontherapy, the dose, dose rate and energy loss pulse-height spectra in a diamond microdosimeter were recorded at multiple points along depth of a water-equivalent plastic phantom. The dose-mean lineal energy (y¯D) values were computed from experimental data and compared to silicon on insulator (SOI) microdosimeter literature results. In addition, the measured dose profile, pulse height spectra and y¯D values were benchmarked with a numerical simulation using TOPAS and Geant4 toolkits. These first clinical tests of a novel system confirm that diamond is a promising candidate for a tissue equivalent, radiation hard, high spatial resolution microdosimeter in beam quality assurance of proton therapy.

Preliminary Investigation into the regeneration of luminescent signal in nanoDot OSLDs.

PURPOSE: Reuse of optically stimulated luminescent dosimeters (OSLDs) has been suggested in prior works by using a light source to erase the dosimeter's signal (optical bleaching) and recharacterizing the dosimeter's sensitivity based on its dose history. However, depending on the wavelength of the bleaching source and the dosimeter's dose history this may be problematic due to the presence of deep dosimetric traps and the phototransfer mechanism observed in Al2 O3 . In this work we examine the regeneration of signal in OSL nanoDots, with prior irradiation history, following their bleaching from a light source containing blue wavelengths. METHODS: Irradiations were performed on 33 nanoDots at a dose range of 5-3000 cGy using 6 MV and 1000-3000 cGy using 220 kV x rays, with three nanoDots irradiated at each dose value. Following their irradiation, nanoDots were bleached using blue light for a period of 1 h. The postbleached signal in nanoDots was measured over a 27-day period to track any changes in their measured signal due to the migration of charge carriers from deep dosimetric traps to shallower traps of the dosimeter. RESULTS: The growth extent and growth rate observed in bleached nanoDots were observed to be dependent on the dosimeter's accumulated dose history and energy of the radiation source. The 12 nanoDots with prior irradiation history of 500, 1000, 2000, and 3000 cGy from 6 MV x rays exhibit an increase in measured signal that range from 220 to 5229 PMT counts when measured the first day postbleaching to 408-8710 PMT counts when measured on the 27th day postbleaching, which may be substantial depending on the application regarding the dosimeter's reuse. CONCLUSION: These findings caution against the reuse and optical bleaching of nanoDots with prior irradiation history exceeding 100 cGy and demonstrate an energy, accumulated dose, and time dependence in the regeneration of signal in postbleached nanoDots with prior irradiation history.

Transient Electrical and Optical Characteristics of Electron and Proton Irradiated SiGe Detectors.

The particle detector degradation mainly appears through decrease of carrier recombination lifetime and manifestation of carrier trapping effects related to introduction of carrier capture and emission centers. In this work, the carrier trap spectroscopy in Si1-xGex structures, containing either 1 or 5% of Ge, has been performed by combining the microwave probed photoconductivity, pulsed barrier capacitance transients and spectra of steady-state photo-ionization. These characteristics were examined in pristine, 5.5 MeV electron and 1.6 MeV proton irradiated Si and SiGe diodes with n+p structure.

MR-safe personal radiation dosimeters.

Magnetic resonance imaging (MRI) is being rapidly integrated for cancer treatments-such systems are referred to as MRI-guided radiation therapy (MRIgRT). As the magnet of an MRI scanner is always on, the presence of a strong static magnetic field from the MRI scanner during radiotherapy delivery presents new challenges. One of the challenges is that a personal radiation dosimeter used to estimate the radiation dose deposited in an individual wearing the device must be MR-safe. No such devices, however, are currently available. In this work we first modified an existing personal dosimeter (by removing a metal clip) to make it MR-safe and then investigated potential effects of magnetic field on dosimeter readings, i.e., optically stimulated luminescent dosimeter (OSLD) readings. We found that the effect of magnetic field on OSLD sensitivity was within radiation protection tolerance levels. OSLD personal dosimeters can be directly used in conjunction with MRIgRT radiation protection purposes.

Initial testing of a pixelated silicon detector prototype in proton therapy.

As technology continues to develop, external beam radiation therapy is being employed, with increased conformity, to treat smaller targets. As this occurs, the dosimetry methods and tools employed to quantify these fields for treatment also have to evolve to provide increased spatial resolution. The team at the University of Wollongong has developed a pixelated silicon detector prototype known as the dose magnifying glass (DMG) for real-time small-field metrology. This device has been tested in photon fields and IMRT. The purpose of this work was to conduct the initial performance tests with proton radiation, using beam energies and modulations typically associated with proton radiosurgery. Depth dose and lateral beam profiles were measured and compared with those collected using a PTW parallel-plate ionization chamber, a PTW proton-specific dosimetry diode, EBT3 Gafchromic film, and Monte Carlo simulations. Measurements of the depth dose profile yielded good agreement when compared with Monte Carlo, diode and ionization chamber. Bragg peak location was measured accurately by the DMG by scanning along the depth dose profile, and the relative response of the DMG at the center of modulation was within 2.5% of that for the PTW dosimetry diode for all energy and modulation combinations tested. Real-time beam profile measurements of a 5 mm 127 MeV proton beam also yielded FWHM and FW90 within ±1 channel (0.1 mm) of the Monte Carlo and EBT3 film data across all depths tested. The DMG tested here proved to be a useful device at measuring depth dose profiles in proton therapy with a stable response across the entire proton spread-out Bragg peak. In addition, the linear array of small sensitive volumes allowed for accurate point and high spatial resolution one-dimensional profile measurements of small radiation fields in real time to be completed with minimal impact from partial volume averaging.

A Fast Experimental Scanner for Proton CT: Technical Performance and First Experience with Phantom Scans.

We report on the design, fabrication, and first tests of a tomographic scanner developed for proton computed tomography (pCT) of head-sized objects. After extensive preclinical testing, pCT is intended to be employed in support of proton therapy treatment planning and pre-treatment verification in patients undergoing particle-beam therapy. The scanner consists of two silicon-strip telescopes that track individual protons before and after the phantom, and a novel multistage scintillation detector that measures a combination of the residual energy and range of the proton, from which we derive the water equivalent path length (WEPL) of the protons in the scanned object. The set of WEPL values and the associated paths of protons passing through the object over a 360° angular scan are processed by an iterative, parallelizable reconstruction algorithm that runs on modern GP-GPU hardware. In order to assess the performance of the scanner, we have performed tests with 200 MeV protons from the synchrotron of the Loma Linda University Medical Center and the IBA cyclotron of the Northwestern Medicine Chicago Proton Center. Our first objective was calibration of the instrument, including tracker channel maps and alignment as well as the WEPL calibration. Then we performed the first CT scans on a series of phantoms. The very high sustained rate of data acquisition, exceeding one million protons per second, allowed a full 360° scan to be completed in less than 10 minutes, and reconstruction of a CATPHAN 404 phantom verified accurate reconstruction of the proton relative stopping power in a variety of materials.

Light-Sharing Interface for dMiCE Detectors Using Sub-Surface Laser Engraving.

We have previously reported on dMiCE, a method of resolving depth or interaction (DOI) in a pair of discrete crystals by encoding light sharing properties as a function of depth in the interface of a crystal-element pair. A challenge for this method is the cost and repeatability of interface treatment for each crystal pair. In this work, we report our preliminary results on using sub-surface laser engraving (SSLE) as a means of forming this depth-dependent interface in a dMiCE detector. A surplus first-generation SSLE system was used to create a partially reflective layer 100-microns thick at the boundary between two halves of a 1.4-by-2.9-by-20 mm3 LYSO crystal. The boundary of these paired crystal elements was positioned between two 3-mm wide Silicon photomultiplier arrays. The responses of these two photodetectors were acquired for an ensemble of 511-keV photons collimated to interact at a fixed depth in just one crystal element. Interaction position was then varied to measure detector response as a function of depth, which was then used to maximum-likelihood positions. Despite use of sub-optimal SSLE processing we found an average DOI resolution of 3.4 mm for front-sided readout and 3.9 mm for back-sided readout while obtaining energy resolutions on the order of 10%. We expect DOI resolution can be improved significantly by optimizing the SSLE process and pattern.

A 2D 4×4 Channel Readout ASIC for Pixelated CdTe Detectors for Medical Imaging Applications.

We present a 16-channel readout integrated circuit (ROIC) with nanosecond-resolution time to digital converter (TDC) for pixelated Cadmium Telluride (CdTe) gamma-ray detectors. The 4 × 4 pixel array ROIC is the proof of concept of the 10 × 10 pixel array readout ASIC for positron-emission tomography (PET) scanner, positron-emission mammography (PEM) scanner, and Compton gamma camera. The electronics of each individual pixel integrates an analog front-end with switchable gain, an analog to digital converter (ADC), configuration registers, and a 4-state digital controller. For every detected photon, the pixel electronics provides the energy deposited in the detector with 10-bit resolution, and a fast trigger signal for time stamp. The ASIC contains the 16-pixel matrix electronics, a digital controller, five global voltage references, a TDC, a temperature sensor, and a band-gap based current reference. The ASIC has been fabricated with TSMC 0.25 µm mixed-signal CMOS technology and occupies an area of 5.3 mm × 6.8 mm. The TDC shows a resolution of 95.5 ps, a precision of 600 ps at full width half maximum (FWHM), and a power consumption of 130 µW. In acquisition mode, the total power consumption of every pixel is 200 µW. An equivalent noise charge (ENC) of 160 e-RMS at maximum gain and negative polarity conditions has been measured at room temperature.

A look at radiation detectors and their applications in medical imaging.

The effectiveness and precision of disease diagnosis and treatment have increased, thanks to developments in clinical imaging over the past few decades. Science is developing and progressing steadily in imaging modalities, and effective outcomes are starting to show up as a result of the shorter scanning periods needed as well as the higher-resolution images generated. The choice of one clinical device over another is influenced by technical disparities among the equipment, such as detection medium, shorter scan time, patient comfort, cost-effectiveness, accessibility, greater sensitivity and specificity, and spatial resolution. Lately, computational algorithms, artificial intelligence (AI), in particular, have been incorporated with diagnostic and treatment techniques, including imaging systems. AI is a discipline comprised of multiple computational and mathematical models. Its applications aided in manipulating sophisticated data in imaging processes and increased imaging tests' accuracy and precision during diagnosis. Computed tomography (CT), positron emission tomography (PET), and Single Photon Emission Computed Tomography (SPECT) along with their corresponding radiation detectors have been reviewed in this study. This review will provide an in-depth explanation of the above-mentioned imaging modalities as well as the radiation detectors that are their essential components. From the early development of these medical instruments till now, various modifications and improvements have been done and more is yet to be established for better performance which calls for a necessity to capture the available information and record the gaps to be filled for better future advances.

High-Performance and Stable Perovskite X-ray Detection and Imaging Based on a Ti Cathode.

High-energy radiation detectors with a good imaging resolution, fast response, and high sensitivity are desired to operate at a high electric field. However, strong ion migration triggered by electrochemical reactions at the interface between a high-potential electrode and an organic-inorganic hybrid perovskite limits the stability of radiation detectors under a high electric field. Herein, we demonstrate that such ion migration could be effectively suppressed in devices with a Ti cathode, even at a high electric field of 50 V mm-1, through time-of-flight secondary-ion mass spectrometry. X-ray photoelectron spectroscopy illustrates that Ti-N bonds formed at the interface of MAPbBr3 perovskite single crystals/Ti electrode effectively inhibit the electrochemical reaction in organic-inorganic hybrid perovskite devices and ultimately improve the operating stability under a high electric field. The device with a Ti electrode reaches a high sensitivity of 96 ± 1 mC Gyair-1 cm-2 and a low detection limit of 2.8 ± 0.3 nGy s-1 under hard X-ray energy.