ABSTRACT
Anaerobiospirillum succiniciproducens is a gram-negative, spiral-shaped anaerobe, that is a rare but potentially lethal cause of bacteremia in humans, particularly in immunocompromised hosts. We reported a 69-year-old HIV-infected male presenting with dysphagia, odynophagia and fulminant pneumonia who died. In addition, in a literature review, we summarized the characteristics of 19 adult patients with A. succiniciproducens bacteremia, which were confirmed by matrix-assisted laser desorption ionization-time of flight mass spectrometry or molecular methods. Among those, the presentation of gastrointestinal conditions was the only independent risk factor for mortality. Clinicians should be aware of this pathogen, especially when a culture is negative but a Gram stain reveals gram-negative spiral-shaped bacteria.
Subject(s)
Anaerobiospirillum/genetics , Anaerobiospirillum/isolation & purification , Anaerobiospirillum/pathogenicity , Gram-Negative Bacterial Infections/etiology , HIV Infections/blood , HIV Infections/complications , HIV Infections/microbiology , Aged , Fatal Outcome , Gram-Negative Bacterial Infections/genetics , Gram-Negative Bacterial Infections/mortality , HIV Infections/mortality , Humans , Male , TaiwanABSTRACT
Anaerobiospirillum succiniciproducens (A succiniciproducens), a spiral, Gram-negative anaerobic rod which is part of the normal intestinal flora of cats and dogs, has rarely been reported as a cause of bacteremia and diarrhea in humans, particularly in immunocompromised hosts. Although it can be associated with significant mortality, the full extent of its pathogenicity, clinical spectrum, and optimal therapy remain to be determined. We review the available literature on microbiology, clinical manifestations, and treatment options for Anaerobiospirillum infection.
Subject(s)
Anaerobiospirillum/pathogenicity , Bacteremia/diagnosis , Bacteremia/therapy , Gram-Negative Bacterial Infections/diagnosis , Gram-Negative Bacterial Infections/therapy , Bacteremia/microbiology , Gram-Negative Bacterial Infections/microbiology , HumansABSTRACT
Anaerobiospirillum thomasii ha sido descrito como causante de diarrea en humanos, pero no se han informado bacteriemias asociadas a este organismo. En esta comunicación describimos el primer aislamiento de A. thomasii como causa de bacteriemia fatal en una paciente alcohólica
Anaerobiospirillum thomasii has been reported as a causative agent of diarrhea in humans; however no bacteremia associated with this pathogen has been described so far. We present here the first case of fatal A. thomasii bacteremia in an alcoholic patient