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Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury.

Xie, Min; Cho, Geoffrey W; Kong, Yongli; Li, Dan L; Altamirano, Francisco; Luo, Xiang; Morales, Cyndi R; Jiang, Nan; Schiattarella, Gabriele G; May, Herman I; Medina, Jessica; Shelton, John M; Ferdous, Anwarul; Gillette, Thomas G; Hill, Joseph A.

Circ Res ; 129(3): 435-450, 2021 07 23.

Article in English | MEDLINE | ID: mdl-34111934

ABSTRACT

[Figure: see text].

Subject(s)

Autophagy , Beclin-1/pharmacology , Myocardial Reperfusion Injury/metabolism , Myocytes, Cardiac/metabolism , Animals , Autophagy-Related Protein 7/genetics , Autophagy-Related Protein 7/metabolism , Beclin-1/therapeutic use , Cells, Cultured , Mice , Mice, Inbred C57BL , Myocardial Contraction , Myocardial Reperfusion Injury/drug therapy , Myocytes, Cardiac/drug effects , Myocytes, Cardiac/physiology , Rats , Rats, Sprague-Dawley , Reactive Oxygen Species/metabolism , Recombinant Proteins/pharmacology , Recombinant Proteins/therapeutic use

ABSTRACT

Subject(s)

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