Choosing a career in industry: An interview with Rachel Haurwitz.

Scientists often contemplate careers in academia versus the biotech industry. We spoke with Dr. Rachel Haurwitz about her career trajectory, being a female scientist in the biotech world, how research in academia compares to industry, and career advice for young scientists thinking about venturing outside of academia into this area.

No evidence for globally coherent warm and cold periods over the preindustrial Common Era.

Earth's climate history is often understood by breaking it down into constituent climatic epochs1. Over the Common Era (the past 2,000 years) these epochs, such as the Little Ice Age2-4, have been characterized as having occurred at the same time across extensive spatial scales5. Although the rapid global warming seen in observations over the past 150 years does show nearly global coherence6, the spatiotemporal coherence of climate epochs earlier in the Common Era has yet to be robustly tested. Here we use global palaeoclimate reconstructions for the past 2,000 years, and find no evidence for preindustrial globally coherent cold and warm epochs. In particular, we find that the coldest epoch of the last millennium-the putative Little Ice Age-is most likely to have experienced the coldest temperatures during the fifteenth century in the central and eastern Pacific Ocean, during the seventeenth century in northwestern Europe and southeastern North America, and during the mid-nineteenth century over most of the remaining regions. Furthermore, the spatial coherence that does exist over the preindustrial Common Era is consistent with the spatial coherence of stochastic climatic variability. This lack of spatiotemporal coherence indicates that preindustrial forcing was not sufficient to produce globally synchronous extreme temperatures at multidecadal and centennial timescales. By contrast, we find that the warmest period of the past two millennia occurred during the twentieth century for more than 98 per cent of the globe. This provides strong evidence that anthropogenic global warming is not only unparalleled in terms of absolute temperatures5, but also unprecedented in spatial consistency within the context of the past 2,000 years.

Prison Papermaking: Colonial Ideals of Industrial Experimentation in India.

This article questions the economic rationale of colonial experimentation and prison labor, arguing that for many administrators a prison-based experiment's success mattered less than its existence. It examines the position of convict labor and penal discipline within colonial industrial experiments in colonial India, where convicts performed experiments for what one administrator described as "the most penal" form of labor, papermaking. The belief that Indian fibers could open a new export market for global papermaking meant that prisons became prominent sites of experimentation with new pulps. Regional prisons gained state monopolies for handmade paper, often decimating local independent producers. Yet prison and industrial officers counterintuitively positioned the frequent failures of papermaking experiments as a continuing potential source for industrial improvement. They argued that the failures demonstrated the need to improve discipline and supervision. Prison experiments slotted convicts into repetitive, mechanized roles that served European investigations into the utility of Indian products.

European Technical Democracy? How Consumer Associations Did-or Did Not-Shape the 1980s Automotive Environmental Standards.

Did the 1980s automotive standards reflect the European Economic Community's move toward a "technical democracy" or a broader democratic deficit? In the early 1980s, Europe's automotive sector faced multiple challenges: the European Commission's desire to harmonize technical standards and achieve greater European integration, intense competition between manufacturers, and environmental issues like acid rain. Debates on reducing air pollution focused on unleaded petrol and catalytic converters. Two associations representing civil society in Brussels responded to the increase in environmental concerns with a 1982 joint campaign. Despite a rich historiography on pollutant emission standards, highlighting the strategies of governments and companies, no study has dealt with the role nongovernmental organizations played. Based on public and private archives, particularly those of the European Bureau of Consumers' Unions, this article argues the new regulations did not result from the EU's consultation with civil society organizations like consumer groups but rather with the automotive industry.

Early atmospheric contamination on the top of the Himalayas since the onset of the European Industrial Revolution.

Because few ice core records from the Himalayas exist, understanding of the onset and timing of the human impact on the atmosphere of the "roof of the world" remains poorly constrained. We report a continuous 500-y trace metal ice core record from the Dasuopu glacier (7,200 m, central Himalayas), the highest drilling site on Earth. We show that an early contamination from toxic trace metals, particularly Cd, Cr, Mo, Ni, Sb, and Zn, emerged at high elevation in the Himalayas at the onset of the European Industrial Revolution (∼1780 AD). This was amplified by the intensification of the snow accumulation (+50% at Dasuopu) likely linked to the meridional displacement of the winter westerlies from 1810 until 1880 AD. During this period, the flux and crustal enrichment factors of the toxic trace metals were augmented by factors of 2 to 4 and 2 to 6, respectively. We suggest this contamination was the consequence of the long-range transport and wet deposition of fly ash from the combustion of coal (likely from Western Europe where it was almost entirely produced and used during the 19th century) with a possible contribution from the synchronous increase in biomass burning emissions from deforestation in the Northern Hemisphere. The snow accumulation decreased and dry winters were reestablished in Dasuopu after 1880 AD when lower than expected toxic metal levels were recorded. This indicates that contamination on the top of the Himalayas depended primarily on multidecadal changes in atmospheric circulation and secondarily on variations in emission sources during the last 200 y.

Early onset of industrial-era warming across the oceans and continents.

The evolution of industrial-era warming across the continents and oceans provides a context for future climate change and is important for determining climate sensitivity and the processes that control regional warming. Here we use post-ad 1500 palaeoclimate records to show that sustained industrial-era warming of the tropical oceans first developed during the mid-nineteenth century and was nearly synchronous with Northern Hemisphere continental warming. The early onset of sustained, significant warming in palaeoclimate records and model simulations suggests that greenhouse forcing of industrial-era warming commenced as early as the mid-nineteenth century and included an enhanced equatorial ocean response mechanism. The development of Southern Hemisphere warming is delayed in reconstructions, but this apparent delay is not reproduced in climate simulations. Our findings imply that instrumental records are too short to comprehensively assess anthropogenic climate change and that, in some regions, about 180 years of industrial-era warming has already caused surface temperatures to emerge above pre-industrial values, even when taking natural variability into account.

How to communicate large-scale social challenges: The problem of the disappearing American corporation.

Social science has distinct advantages and challenges when it comes to communicating its findings to the public. Its topics are often highly accessible to the general public, yet its findings may be counterintuitive and politically contentious. Conveying recent changes in the organization of the American economy provides an illustration of the difficulties and opportunities for engaging the public. The declining number of public corporations in the United States is associated with a shrinking middle class, lower opportunities for upward mobility, and a fraying social safety net, with important implications for individuals and public policy. Attempting to convey this set of findings to a broad public has demonstrated that some strategies and communication channels work better than others, and that some online media are particularly effective.

A West African Middle Stone Age site dated to the beginning of MIS 5: Archaeology, chronology, and paleoenvironment of the Ravin Blanc I (eastern Senegal).

The Ravin Blanc I archaeological occurrence, dated to MIS 5, provides unprecedented data on the Middle Stone Age (MSA) of West Africa since well-contextualized archaeological sites pre-dating MIS 4/3 are extremely rare for this region. The combined approach on geomorphology, phytolith analysis, and OSL date estimations offers a solid framework for the MSA industry comprised in the Ravin Blanc I sedimentary sequence. The paleoenvironmental reconstruction further emphasizes on the local effects of the global increase in moisture characterizing the beginning of the Upper Pleistocene as well as the later shift to more arid conditions. The lithic industry, comprised in the lower part of the sequence and dated to MIS 5e, shows core reduction sequences among which Levallois methods are minor, as well as an original tool-kit composition, among which pieces with single wide abrupt notches, side-scrapers made by inverse retouch, and a few large crudely shaped bifacial tools. The Ravin Blanc I assemblage has neither a chronologically equivalent site to serve comparisons nor a clear techno-typological correspondent in West Africa. However, the industry represents an early MSA technology that could either retain influences from the southern West African 'Sangoan' or show reminiscences of the preceding local Acheulean. A larger-scale assessment of behavioral dynamics at work at the transition period between the Middle to Upper Pleistocene is discussed in view of integrating this new site to the global perception of this important period in the MSA evolutionary trajectories.

Defining the anthropocene.

Time is divided by geologists according to marked shifts in Earth's state. Recent global environmental changes suggest that Earth may have entered a new human-dominated geological epoch, the Anthropocene. Here we review the historical genesis of the idea and assess anthropogenic signatures in the geological record against the formal requirements for the recognition of a new epoch. The evidence suggests that of the various proposed dates two do appear to conform to the criteria to mark the beginning of the Anthropocene: 1610 and 1964. The formal establishment of an Anthropocene Epoch would mark a fundamental change in the relationship between humans and the Earth system.

North and south: A comprehensive analysis of non-adult growth and health in the industrial revolution (AD 18th-19th C), England.

OBJECTIVE: Stark health inequalities exist in the present day between the North and South of England, with people in the South, overall, experiencing better health across a range of parameters (e.g., life expectancy and number of years spent in good health). Bioarchaeological studies of skeletal remains from cemeteries across this geographical divide have the ability to provide a temporal perspective on the etiology, longevity, and nature of this disparity. METHODS: In total 574 non-adults (0-17 years) from six urban sites (c. AD 1711-1856) were analyzed from the North and South of England. Measurements of long bone length, cortical thickness, and vertebral dimensions were analyzed alongside both skeletal and dental palaeopathological data to assess patterns of disease and growth disruption between skeletal samples. RESULTS: There were few significant differences in growth parameters between the six sites in relation to geographical location. However, the northern-based sample Coach Lane (North Shields) demonstrated some of the highest rates of pathology, with metabolic disease being particularly prevalent. DISCUSSION: Northern and southern populations suffered alike from the detrimental environmental conditions associated with urban centers of the 18th-19th centuries. However, the elevated prevalence of vitamin D deficiency seen within the Coach Lane sample is indicative of a regionally specific risk that may be related to latitude, and/or the influence of particular industries operating in the North-East.

Record of Hg pollution around outset of colonization in Southern Brazil.

This study presents results of a sediment core located in Coroa de Boi Bay, a not dredged cove within Patos Estuary, Southern Brazil. The distribution of metals (Hg, Cu, Pb) and U in the sediment profile records several contamination events since pre-colonial times to present days. A joint assessment of the distribution of these parameters and the consultation to historical documents allowed us to establish causal links between concentrations anomalies in the sediments and ancient anthropogenic contamination in the area. During the industrial period, sedimentation rates in the bay ranged from 3.4 to 5.5 mm year-1. Applying a sedimentation rate previously calculated for undisturbed sediments in the Patos Estuary, we trace the beginning of Hg contamination as having started in the colonial period in Southern Brazil, soon after a Hispanic-Lusitanian conflict situation in South America. The most probable source of Hg contamination during this period was carroting technology used in fur processing.

Corporate Mortality Files and Late Industrial Necropolitics.

This article critically examines the corporate production, archival politics, and socio-legal dimensions of corporate mortality files (CMFs), the largest corporate archive developed by IBM to systematically document industrial exposures and occupational health outcomes for electronics workers. I first provide a history of IBM's CMF project, which amounts to a comprehensive mortality record for IBM employees over the past 40 years. Next, I explore a recent case in Endicott, New York, birthplace of IBM, where the U.S. National Institute for Occupational Safety and Health studied IBM's CMFs for workers at IBM's former Endicott plant. Tracking the production of the IBM CMF, the strategic avoidance of this source of big data as evidence for determining a recent legal settlement, alongside local critiques of the IBM CMF project, the article develops what I call "late industrial necropolitics."

[From the History of 1985 Anti-Alcoholic Company in the USSR].

The article considers history and results of 1985 anti-alcoholic company. The anti-alcoholic company was initiated from higher-ups and hastily implemented during Gorbachev perestroika of economic and social life in the country and brought no expected results and for many years moved back the resolution of this vital medical social problem.

End of the Little Ice Age in the Alps forced by industrial black carbon.

Glaciers in the European Alps began to retreat abruptly from their mid-19th century maximum, marking what appeared to be the end of the Little Ice Age. Alpine temperature and precipitation records suggest that glaciers should instead have continued to grow until circa 1910. Radiative forcing by increasing deposition of industrial black carbon to snow may represent the driver of the abrupt glacier retreats in the Alps that began in the mid-19th century. Ice cores indicate that black carbon concentrations increased abruptly in the mid-19th century and largely continued to increase into the 20th century, consistent with known increases in black carbon emissions from the industrialization of Western Europe. Inferred annual surface radiative forcings increased stepwise to 13-17 W⋅m(-2) between 1850 and 1880, and to 9-22 W⋅m(-2) in the early 1900s, with snowmelt season (April/May/June) forcings reaching greater than 35 W⋅m(-2) by the early 1900s. These snowmelt season radiative forcings would have resulted in additional annual snow melting of as much as 0.9 m water equivalent across the melt season. Simulations of glacier mass balances with radiative forcing-equivalent changes in atmospheric temperatures result in conservative estimates of accumulating negative mass balances of magnitude -15 m water equivalent by 1900 and -30 m water equivalent by 1930, magnitudes and timing consistent with the observed retreat. These results suggest a possible physical explanation for the abrupt retreat of glaciers in the Alps in the mid-19th century that is consistent with existing temperature and precipitation records and reconstructions.

Firm-Led Malaria Prevention in the United States, 1910-1920.

In the absence of capable government services, a railroad company in Texas and multiple cotton mills in North Carolina successfully prevented malaria in the early twentieth century. This Article looks through the lens of economics to understand how and why people had the incentive to privately coordinate malaria prevention during this time, but not after. These firms, motivated by increases in productivity and profit, implemented extensive anti-malaria programs and used their hierarchical organizational structures to monitor performance. The factors underlying the decline of private prevention include a fall in the overall rate of malaria, the increasing presence of the federal government, and technological innovations that lowered exposure to mosquitoes. Understanding how, why, and when firms can prevent diseases has important implications for current disease policy, especially where governments, international organizations, and technologies are not enough.

Innovation by coercion: Emerging institutionalization of university-industry collaborations in Russia.

This article explores the emerging institutionalization of collaborative university-industry networks in Russia. The Russian government has attempted to use a top-down public policy scheme to stimulate and promote network-building in the R&D sector. In order to understand the initial organizational responses that universities and companies select while structuring collaborations, the article utilizes conceptual perspectives from institutional theory, especially drawing on arguments from strategic choice, network-building, and network failure studies.