[Efficacy of treatment of chronic destructive forms of apical periodontitis using oral decontamination antibiotic therapy]. / Effektivnost' izlecheniia khronicheskikh destruktivnykh form verkhushechnogo periodontita s ispol'zovaniem peroral'noi dekontaminatsionnoi antibakterial'noi terapii.

The efficiency of preventive oral antibiotic therapy before the root channel filling was evaluated in 78 patients with granulating and granulomatous chronic periodontitis. Positive clinical changes were observed after lincomycin or rondomycin therapy (p = 0.017). The number of complaints was also less in the latter group (p > 0.05). The incidence of x-ray restoration of periapical foci of bone tissue destruction during 6 and 12 months was significantly higher (p < 0.05 and p < 0.01) after preventive treatment with lincomycin or rondomycin, characterized by potent osteotropic effects (decontamination with rondomycin 81.8%, with lincomycin 70.3% vs. 31.0% without decontamination therapy).

[Bioavailability of drug forms of tetracycline-group semisynthetic preparations for internal use]. / Biodostupnost' lekarstvennykh form dlia priema vnutr' polusinteticheskikh preparatov gruppy tetratsiklina.

Bioavailability of methacycline capsules manufactured by two different firms was studied and it was shown that they had statistically significant differences. Conditions for investigation of the rate of methacycline transfer from the pharmaceutical form into solution were developed with the use of a "rotating basket". Such investigations provided in vitro prediction of the drug bioavailability. The effect of additives on bioavailability of methacycline capsules was found. Study of bioavailability of doxycycline capsules manufactured by the same two firms revealed no differences.

[Indications and limits of local tri-methacycline therapy in pyogenic infections of the eye (author's transl)]. / Indikationen und Grenzen der lokalen Tri-Methacyclin-Behandlung von pyogenen Infektionen des Auges

In addition to the preoperative treatment of acute dacryocystitis local administration of tri-methacycline proved to be of benefit in cases of endophthalmitis consequent to injury. Its subconjunctival administration is the therapy of choice for serpentic ulcers of the cornea.