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Involvement of substance P and the neurokinin-1 receptor in radiation-induced hair loss in mice.

Yamamoto, Kouichi; Kureyama, Naoko; Asano, Keiko; Ikeda, Toshiji; Yamatodani, Atsushi.

J Pharmacol Sci ; 112(1): 118-20, 2010.

Article in English | MEDLINE | ID: mdl-20051651

ABSTRACT

We investigated the involvement of substance P (SP) and the neurokinin-1 receptor (NK(1)R) in the development of radiation-induced hair loss in mice. A dose of 40 Gy of gamma irradiation induced hair loss from the 10th to at least the 60th day after irradiation. A specific NK(1)R antagonist, CP-99,994, significantly delayed radiation-induced hair loss and reduced its severity. Furthermore, gamma irradiation induced the expression of preprotachykinin-A, a precursor protein of SP, mRNA in irradiated murine skin on the 10th and 30th days after irradiation. These results indicated that gamma irradiation-induced hair loss was mediated by SP via NK(1)R.

Subject(s)

Alopecia/metabolism , Radiation Injuries, Experimental/metabolism , Receptors, Neurokinin-1/physiology , Substance P/physiology , Alopecia/drug therapy , Animals , Male , Mice , Mice, Inbred C57BL , Neurokinin-1 Receptor Antagonists , Piperidines/pharmacology , Piperidines/therapeutic use , Protein Precursors/biosynthesis , Protein Precursors/radiation effects , Radiation Injuries, Experimental/drug therapy , Receptors, Neurokinin-1/radiation effects , Substance P/radiation effects , Tachykinins/biosynthesis , Tachykinins/radiation effects

ABSTRACT

Subject(s)

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