1.
Org Biomol Chem
; 21(48): 9530-9533, 2023 Dec 13.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38009012
RESUMEN
A Pd-catalyzed selective tandem cyclization of the Ugi adduct via Buchwald-Hartwig/C-H bond functionalization reactions has been reported. This sequence offers an interesting approach for synthesizing a wide range of pyrido[1,2-a]pyrazine-3,6-dione scaffolds under mild reaction conditions in moderate to excellent yields. The scope and limitations of the protocol are discussed.