Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction.

BACKGROUND: Whether revascularization by percutaneous coronary intervention (PCI) can improve event-free survival and left ventricular function in patients with severe ischemic left ventricular systolic dysfunction, as compared with optimal medical therapy (i.e., individually adjusted pharmacologic and device therapy for heart failure) alone, is unknown. METHODS: We randomly assigned patients with a left ventricular ejection fraction of 35% or less, extensive coronary artery disease amenable to PCI, and demonstrable myocardial viability to a strategy of either PCI plus optimal medical therapy (PCI group) or optimal medical therapy alone (optimal-medical-therapy group). The primary composite outcome was death from any cause or hospitalization for heart failure. Major secondary outcomes were left ventricular ejection fraction at 6 and 12 months and quality-of-life scores. RESULTS: A total of 700 patients underwent randomization - 347 were assigned to the PCI group and 353 to the optimal-medical-therapy group. Over a median of 41 months, a primary-outcome event occurred in 129 patients (37.2%) in the PCI group and in 134 patients (38.0%) in the optimal-medical-therapy group (hazard ratio, 0.99; 95% confidence interval [CI], 0.78 to 1.27; P = 0.96). The left ventricular ejection fraction was similar in the two groups at 6 months (mean difference, -1.6 percentage points; 95% CI, -3.7 to 0.5) and at 12 months (mean difference, 0.9 percentage points; 95% CI, -1.7 to 3.4). Quality-of-life scores at 6 and 12 months appeared to favor the PCI group, but the difference had diminished at 24 months. CONCLUSIONS: Among patients with severe ischemic left ventricular systolic dysfunction who received optimal medical therapy, revascularization by PCI did not result in a lower incidence of death from any cause or hospitalization for heart failure. (Funded by the National Institute for Health and Care Research Health Technology Assessment Program; REVIVED-BCIS2 ClinicalTrials.gov number, NCT01920048.).

Children Show a Gender Gap in Negotiation.

In the United States, there is an unfortunate yet pervasive gender gap in wages: Women tend to make less than men for doing the same work. One prominent account for why this wage gap exists is that women and men negotiate differently. However, we currently do not know whether differences in negotiation are a product of extensive experience or are deeply rooted in development. Here, we brought data from children to bear on this important question. We gave 240 children between the ages of 4 and 9 years old a chance to negotiate for a bonus with a female or a male evaluator. Boys asked for the same bonus from a male and a female evaluator. Older girls, in contrast, asked for a smaller bonus from a male than a female evaluator. Our findings suggest that a gender gap in negotiation emerges surprisingly early in development, highlighting childhood as a key period for interventions.

Checking gender bias: Parents and mentors perceive less chess potential in girls.

Girls and women are underrepresented in chess. Here, we explored the role of gender bias in this phenomenon. Specifically, we investigated whether parents and mentors (e.g., coaches) show bias against the female youth players in their lives. Parents and mentors (N = 286; 90.6% men) recruited through the U.S. Chess Federation reported their evaluations of and investment in youth players (N = 654). We found evidence of bias on some, but not all, measures. Most strikingly, parents and mentors thought that female youth players' highest potential chess ratings were on average lower than male players', a bias that was exacerbated among parents and mentors who believed that success in chess requires brilliance. In addition, mentors who endorsed (vs. rejected) this belief also reported that female mentees were more likely to drop out of chess due to low ability. These findings provide the first large-scale evidence of bias against youth female players and hold implications for the role of parents and mentors in other domains that, like chess, are culturally associated with intellectual ability and exhibit substantial gender imbalances (e.g., science and technology). (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Sex and gender essentialism in textbooks.

Several widely used high school biology texts depart from established science.

Infants' visual attention to own-race and other-race faces is moderated by experience with people of different races in their daily lives.

Infants sometimes differentially attend to faces of different races, but how this tendency develops across infancy and how it may vary for infants growing up with different exposure to racial diversity remain unclear. The present study examined the role of experiences with racial diversity on infants' visual attention to different racial groups (specifically own-race vs. other-race groups) in the first year of life via a large-scale study of infants (N = 203; Mage = 6.9 months, range = 3-14 months; 70% White, 8% Asian, 5% Black, 12% multiracial, 4% unreported; 14% Hispanic, 86% non-Hispanic) from across the United States. We tested the role of two forms of racial diversity: that of infants' social networks (reported by parents) and that of infants' neighborhoods (obtained from U.S. Census data). Regardless of age, infants looked longer at other-race faces than own-race faces, but this tendency was moderated by the racial diversity of infants' social networks. Infants with more diverse networks looked equivalently long at own-race and other-race faces, whereas those with less diverse networks looked longer at other-race faces. In contrast, infants' looking behavior was not moderated by the diversity of their neighborhoods. Together, our research suggests that exposure to racial diversity in infants' immediate social networks predicts how infants look to faces of different races, illustrating the context-dependent nature of the development of infants' attention to race. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Coronary Jeopardy Score Predicts Ischemic Etiology in Patients With Left Ventricular Systolic Dysfunction.

While cardiovascular magnetic resonance imaging (CMR) is the gold standard diagnostic test for heart failure etiology, it is not universally available. Our aim was to investigate whether quantifying the extent of coronary disease on angiography can predict the presence of an ischemic etiology. We included 176 patients who underwent CMR and coronary angiography for new heart failure with reduced ejection fraction. Based on CMR, 65% had an ischemic etiology and 35% were non-ischemic. A BCIS jeopardy score threshold ≥6 had 76% sensitivity and 97% specificity. In HFrEF, the extent of coronary disease on angiography can be used to rule in or out an ischemic etiology.