[The use of the antioxidant drink by healthy workers exposed to chemical factors].

In chemical manufacturing along with alimentary factors, workers are exposed to occupational hazards resulting in reduced antitoxic protective properties of the organism. The purpose of the present work was to develop a preventive method for reducing antitoxic functions of the body of healthy workers exposed to chemical factors. We have produced the drink containing carrot juice, honey, olive oil. The study involved 50 employees (the average age was 37.4±5.5 years) with experience of over 15 years. The main group (25 people) were workers with reduced antitoxic function who received the drink before each day's work shift for 10 days, the control group - workers with normal anti-toxic function, which did not take a drink. It was found that antioxidant drink intake by healthy employees of a chemical complex lead to the decrease of the level of molecules of average mass at λ=254 nm and at λ=280 nm by 15.1±7.2%, the activity of gammaglutamyl transferase - by 19.1%, alaninaminotransferase - by 44.1%, aspartataminotrans-ferase - by 34.7% (indicators of the syndrome of endogenous intoxication), the decrease of the content of malondialdehyde (as an indicator of an excessive accumulation of products of lipid peroxidation) - by 43.8%, while the activity of catalase, that indicates an increase in the antitoxic functions of the organism, increased by 37.5%.

[HYGIENIC ASSESSMENT OF WORKING CONDITIONS IN MODERN PETROCHEMICAL INDUSTRY].

In the paper there are reported the results of the performance of hygiene assessment of working conditions in petrochemical industry. The studies have shown that workers' body is exposed to a complex of hazardous occupational factors including a chemical factor, noise, the severity and intensity of the working process. An overall assessment of working conditions corresponds to Class 3.3.

[Specificities of intracellular metabolism in agricultural workers].

The purpose of the study was to identify and assess specific features of intracellular metabolism under the conditions of combined impact of biological and chemical work environment factors in agricultural workers. We have detected an activation of energetic and hydrolytic processes, suppression of antioxidant protection mechanisms in blood cells in workers of basic occupations. A most marked disorder of intracellular metabolism has been identified in poultry female workers. More significant activity deviations of acid phosphatase and glycogen in neutrophils and lymphocytes, myeloperoxidase in neutrophils have diagnosed in these workers.

[Role of laboratory tests in the early diagnosis of metabolic disorders in workers engaged in petrochemical production].

Studies of metabolic processes in petrochemical production workers revealed activation of lipid peroxidation, depressed antioxidant system, altered intracellular metabolism, high prevalence of dyslipidemia and increased serum enzymes levels. The metabolic changes of cellular and subcellular levels were seen in asymptomatic individuals--that supports value of laboratory tests in diagnosis of pathologic processes in petrochemical production workers.

[Assessement of combined impact of hazards on petrochemical and chemical workers' health].

We have conducted a study on working conditions and health status of petrochemical workers. The main hazardous factor of work environment and manufacture process has been found to be work environment air pollution caused by Class 2-3 hazards. Depending on the composition of the current complex of hazards, the manufacture workers comprise three groups determined by the impact of aromatic hydrocarbons, olefin oxides and their combinations. It has been shown that the combined impact of aromatic hydrocarbons and olefin oxides combination may produce a more pronounced hazardous impact on workers' health compared with the impact of aromatic hydrocarbons or olefin oxides taken separately. This may be due to the summing up of biological effects.