RESUMEN
BACKGROUND: In elderly smokers, chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) usually present with dyspnoea. COPD and CHF are associated -almost invariably with concomitant chronic diseases, which contribute to severity and prognosis. OBJECTIVES: We investigated similarities and differences in the clinical presentation, concomitant chronic diseases and risk factors for -mortality and hospitalization at 3-year follow-up in elderly smokers/ex-smokers with a primary diagnosis of COPD or CHF recruited and followed in specialized centers. METHODS: We examined 144 patients with COPD and 96 with CHF, ≥65 years, ≥20 pack/years, and measured COPD Assessment Test (CAT) score, modified Medical Research Council, NYHA, and Charlson Index, routine blood test, estimated glomerular filtration rate, HRCT scan, 6-min walk test. In addition, in each patient we actively searched for CHF, COPD, peripheral vascular disease, and metabolic syndrome. RESULTS: COPD and CHF patients had mild to moderate disease, but the majority was symptomatic. Comorbidities were highly prevalent and often unrecognized in both groups. COPD and CHF patients had a similar risk of hospitalization and death at 3 years. Lower glomerular filtration rate, shorter 6MWT, and ascending aorta calcification score ≥2 were independent predictors of mortality in COPD, whereas previous 12 months hospitalizations, renal disease, and heart diameter were in CHF patients. Lower glomerular filtration rate value, higher CAT score, and lower FEV1/FVC ratio were associated with hospitalization in COPD, while age, lower FEV1% predicted, and peripheral vascular disease were in CHF. CONCLUSIONS: There are relevant similarities and differences between patients with COPD and CHF even when admitted to specialized outpatient centers, suggesting that these patients should be manage in multidisciplinary units.
Asunto(s)
Insuficiencia Cardíaca/epidemiología , Hospitalización/tendencias , Enfermedad Pulmonar Obstructiva Crónica/epidemiología , Fumar/efectos adversos , Anciano , Comorbilidad , Femenino , Estudios de Seguimiento , Humanos , Italia/epidemiología , Masculino , Prevalencia , Pronóstico , Estudios Prospectivos , Factores de Riesgo , Índice de Severidad de la Enfermedad , Fumar/epidemiología , Tasa de Supervivencia/tendencias , Factores de TiempoRESUMEN
The Kounis syndrome was first described in 1991 as'the allergic angina syndrome'which could progress to acute myocardial infarction which was named'allergic myocardial infarction. There are several causes underlying this syndrome including drugs, various conditions and a variety of environmental exposure factors such as animal stings. Hymenoptera stings can induce Kounis syndrome because hymenoptera venom contains allergenic proteins and peptides. The following case report describes a patient who experienced an anaphylactic shock associated with coronary artery ischaemia (inferior ST-segment elevation myocardial infarction) after a bumblebee sting.
Asunto(s)
Alérgenos , Anafilaxia , Angioplastia Coronaria con Balón/métodos , Venenos de Abeja/inmunología , Abejas , Clorfeniramina/administración & dosificación , Hidrocortisona/administración & dosificación , Mordeduras y Picaduras de Insectos , Anafilaxia/tratamiento farmacológico , Anafilaxia/etiología , Anafilaxia/inmunología , Animales , Antialérgicos , Angiografía Coronaria , Vasos Coronarios/efectos de los fármacos , Electrocardiografía , Humanos , Infarto de la Pared Inferior del Miocardio/diagnóstico , Infarto de la Pared Inferior del Miocardio/etiología , Infarto de la Pared Inferior del Miocardio/inmunología , Infarto de la Pared Inferior del Miocardio/terapia , Mordeduras y Picaduras de Insectos/complicaciones , Mordeduras y Picaduras de Insectos/inmunología , Masculino , Persona de Mediana Edad , Stents , Síndrome , Resultado del TratamientoRESUMEN
Breast carcinoma is becoming a spread disease that needs a specif teraphy. Tamoxifen is the first line treatment in patients with positivity of expression of estrogen receptors. The risk of thromboembolism is high in patients treated with tamoxifene indipendent from the neoplastic disease. This work focuses the attention on tamoxifen mechanism of thrombosis.
Asunto(s)
Neoplasias de la Mama/tratamiento farmacológico , Embolia Pulmonar/inducido químicamente , Tamoxifeno/uso terapéutico , Antineoplásicos Hormonales/uso terapéutico , Ecocardiografía , Electrocardiografía , Femenino , Humanos , Embolia Pulmonar/diagnósticoRESUMEN
Boerhaave's syndrome is a very rare disease characterised by a spontaneous rupture of the oesophagus. It is often misdiagnosed and there is no consensus as to the best treatment. We describe a case of a 61 year-old man without significant previous medical history presenting in the emergency room with acute chest and back pain. Despite objective and laboratory tests negative for chest pain screening, computed tomography showed the presence of mediastinal air and pneumothorax consistent with oesophagus rupture. Urgent surgical intervention saved the patient.
Asunto(s)
Dolor en el Pecho/diagnóstico por imagen , Neumotórax/diagnóstico por imagen , Enfermedad Aguda , Dolor en el Pecho/etiología , Diagnóstico Diferencial , Servicio de Urgencia en Hospital , Perforación del Esófago/diagnóstico por imagen , Perforación del Esófago/cirugía , Humanos , Masculino , Enfermedades del Mediastino/diagnóstico por imagen , Enfermedades del Mediastino/cirugía , Persona de Mediana Edad , Neumotórax/etiología , Neumotórax/cirugía , Radiografía , Resultado del Tratamiento , Vómitos/etiologíaRESUMEN
We describe the case of a young female affected by a thymus teratoma coexisting with carcinoid tumor.
RESUMEN
We describe the case of a 78-year-old woman admitted to our department for suspected silent myocardial ischaemia with the evidence of T wave inversion in anterior lead. All the instrumental exams excluded inducible myocardial ischaemia. A gastroscopy showed a moderate hiatal hernia. We postulate that electrocardiogram modification could be attributed to hiatal hernia.
RESUMEN
Bronchoalveolar lavage (BAL) is a minimally invasive method possibly representing a diagnostic tool in the evaluation of interstitial lung diseases (ILDs) of different causes. We first describe herein the morphologic, histochemical, and immunohistochemical features of previously unreported eosinophilic globular deposits of acellular amorphous material of uncertain nature in a relatively large series of 227 BAL samples obtained from patients with various ILDs. Overall, eosinophilic globules were detected in 18 cases (7.9%), 16 of which were in patients with systemic sclerosis (SSc)-related ILD (16/50 [32%]) and in 2 cases of apparently idiopathic usual interstitial pneumonia. Apart from the possible diagnostic information of this finding, in patients with SSc, the globules were significantly related to BAL neutrophilia or eosinophilia and extensive ILD in high-resolution computed tomography (P < .0001). Differential diagnosis with other types of acellular globular materials observed in BAL samples is also discussed.