RESUMEN
BACKGROUND: The aim of this study was to evaluate the role of hypomagnesemia as a risk factor for the development of acute kidney injury (AKI) and non-recovery of renal function in critically ill patients. METHODS: A cohort study was conducted by collecting data from March to June 2011 in 232 patients who were admitted into an intensive care unit (ICU). Magnesium serum levels were measured daily during ICU stay. Hypomagnesemia was defined as an episode of serum magnesium concentration of <0.70 mmol/L during ICU stay. The Risk, Injury, Failure, Loss and End-stage kidney disease (RIFLE) criteria were used to define AKI. Renal function recovery was defined as an absence of AKI by the RIFLE criteria over a 48-h period, or at ICU discharge, in the patients who developed AKI during ICU stay. RESULTS: The presence of hypomagnesemia was similar in patients with or without AKI (47 and 62%, respectively, P = 0.36). The presence of hypomagnesemia was higher in patients who did not recover renal function when compared with patients who recovered renal function (70 versus 31%, P = 0.003). A multivariate analysis identified hypomagnesemia as an independent risk factor for non-recovery of renal function (P = 0.005). Patients with and without hypomagnesemia had similar mortality rates (P = 0.63). CONCLUSIONS: Hypomagnesemia was an independent risk factor for non-recovery of renal function in a cohort of critically ill AKI patients.
Asunto(s)
Lesión Renal Aguda/etiología , Enfermedad Crítica/mortalidad , Mortalidad Hospitalaria , Unidades de Cuidados Intensivos , Riñón/fisiopatología , Deficiencia de Magnesio/complicaciones , Magnesio/sangre , Lesión Renal Aguda/mortalidad , Femenino , Estudios de Seguimiento , Hospitalización , Humanos , Pruebas de Función Renal , Deficiencia de Magnesio/diagnóstico , Masculino , Persona de Mediana Edad , Pronóstico , Estudios Prospectivos , Factores de Riesgo , Tasa de SupervivenciaRESUMEN
OBJECTIVE: To evaluate the relationship between brain damage biomarkers and mortality in the intensive care unit (ICU). METHODS: The sample comprised 70 patients admitted to an ICU. Blood samples were collected from all patients on ICU admission, and levels of S100ß and neuron-specific enolase (NSE) were determined by ELISA. RESULTS: Acute Physiologic and Chronic Health Evaluation (APACHE II) score was associated with mortality, but NSE and S100ß were not associated with this outcome. In contrast, S100ß levels were significantly higher in delirious and non-delirious patients who required mechanical ventilation during ICU stay. CONCLUSION: Levels of brain biomarkers at the time of ICU admission did not predict mortality in critically ill patients.
Asunto(s)
Lesiones Encefálicas/mortalidad , Enfermedad Crítica/mortalidad , Delirio/sangre , Fosfopiruvato Hidratasa/sangre , Subunidad beta de la Proteína de Unión al Calcio S100/sangre , APACHE , Biomarcadores/sangre , Lesiones Encefálicas/sangre , Estudios de Casos y Controles , Ensayo de Immunospot Ligado a Enzimas , Femenino , Humanos , Unidades de Cuidados Intensivos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios ProspectivosRESUMEN
Objective: To evaluate the relationship between brain damage biomarkers and mortality in the intensive care unit (ICU). Methods: The sample comprised 70 patients admitted to an ICU. Blood samples were collected from all patients on ICU admission, and levels of S100β and neuron-specific enolase (NSE) were determined by ELISA. Results: Acute Physiologic and Chronic Health Evaluation (APACHE II) score was associated with mortality, but NSE and S100β were not associated with this outcome. In contrast, S100β levels were significantly higher in delirious and non-delirious patients who required mechanical ventilation during ICU stay. Conclusion: Levels of brain biomarkers at the time of ICU admission did not predict mortality in critically ill patients. .