Asunto(s)
Alopecia , Lepra , Alopecia/patología , Cicatriz/patología , Cejas/patología , Humanos , Lepra/complicaciones , Lepra/patologíaAsunto(s)
Alopecia/diagnóstico , Cicatriz/diagnóstico , Cosméticos/efectos adversos , Trastornos por Fotosensibilidad/diagnóstico , Luz Solar/efectos adversos , Adulto , Anciano , Alopecia/etiología , Alopecia/patología , Cicatriz/etiología , Cicatriz/patología , Cejas , Femenino , Fibrosis , Humanos , Masculino , Persona de Mediana Edad , Pruebas del Parche , Trastornos por Fotosensibilidad/etiología , Trastornos por Fotosensibilidad/patología , Piel/efectos de los fármacos , Piel/patología , Piel/efectos de la radiaciónRESUMEN
In the scope of a research program aiming at the synthesis and pharmacological evaluation of novel possible antiplatelet prototype compounds, exploring bioisosterism principles for molecular design, we describe in this paper the synthesis of new aryl-sulfonamides derivatives, structurally similar to known thromboxane A2 receptor antagonists. The synthetic route used to access the new compounds described herein starts from safrole, an abundant Brazilian natural product, which occurs in Sassafras oil (Ocotea pretiosa). The results from preliminary evaluation of these novel aryl-sulfonamide compounds by the platelet aggregation inhibitory test, using rabbit PRP, induced by ADP, collagen, arachidonic acid, and U46619, identified the N-[2-(4-carboxymethoxyphenyl)ethyl]-6-methyl-3,4-methylenedioxyphe nyl- sulfonamido derivative as the most active among them, presenting in IC50 value for the U-46619-induced platelet aggregation in rabbit platelet-rich plasma: 329 microM.
Asunto(s)
Inhibidores de Agregación Plaquetaria/síntesis química , Inhibidores de Agregación Plaquetaria/farmacología , Safrol/análogos & derivados , Safrol/farmacología , Sulfonamidas/síntesis química , Sulfonamidas/farmacología , Animales , Humanos , Técnicas In Vitro , Agregación Plaquetaria/efectos de los fármacos , Conejos , Safrol/síntesis química , Relación Estructura-ActividadRESUMEN
Wall rocket (Diplotaxis erucoides) is a common Crucifera plant that grows in European and American vineyards and olive groves. We present the cases of 2 farmers with rhinoconjunctivitis and asthma related to wine-growing tasks during D erucoides pollination (March-April). The aim of this work was to demonstrate that occupational symptoms were caused by D erucoides pollen sensitization. Cutaneous tests, specific IgE measurements, conjunctival and bronchial provocation tests, and peak-flow measurements during working days were performed.