RESUMEN
OBJECTIVE: To examine the effect of adding aerobic exercise (AE) to neck-specific exercise treatment for patients with neck pain (NP) to reduce pain and disability. DESIGN: A prospective multicentre randomized controlled trial. SETTING: Physiotherapy outpatient clinics. SUBJECTS: Patients with nonspecific NP. INTERVENTION: Patients with NP were randomly assigned to six weeks of neck-specific exercise with and without the addition of AE. MEASURES: Patients were classified as having a successful or non-successful outcome according to the Global Rating of Change (GROC). Outcome measures included Visual Analogue Scale (VAS), Neck Disability Index (NDI), Fear Avoidance Beliefs Questionnaire (FABQ) and cervicogenic headache. Assessments were performed at six-week, and three- and six-month follow-ups. RESULTS: A total of 139 participants (mean age: 54.6 ± 10.5 years) were recruited (n = 69 AE, n = 70 control). According to GROC, 77.4% of the AE group reported a successful outcome at six months vs. 40% in the control group (P < 0.001). There was a significant reduction in VAS from baseline to six months in the AE vs. control group 6.73 (±1.69) to 1.89 (±1.37) vs. 6.65 (±1.67) to 3.32 (±1.82), respectively (P < 0.001). Significant improvements were also obtained for NDI and FABQ from baseline to six weeks in the AE group: NDI from 16.10 (±4.53) to 7.78 (±4.78) vs. 17.01 (±4.84) to 11.09 (±5.64) in the control group (P = 0.003); FABQ from 33.53 (±9.31) to 20.94 (±841) in the AE vs. 33.45 (±10.20) to 26.83 (±10.79) in the control group (P < 0.001). The AE group also demonstrated significant reduction in cervicogenic headache from baseline to six months (P = 0.003). CONCLUSION: Adding AE to long-term neck-specific exercises is an effective treatment for reducing NP and headache in patients with NP.
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Terapia por Ejercicio , Ejercicio Físico , Dolor de Cuello/rehabilitación , Adulto , Anciano , Método Doble Ciego , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Encuestas y Cuestionarios , Resultado del TratamientoRESUMEN
OBJECTIVE: To determine time of return to work (TRTW) in relation to multivariable predictors among male manual workers after hand injury (HI) over a 12-month follow-up. DESIGN: A cohort study with baseline medical information, functional evaluation, and 3-, 6-, 9-, and 12-month follow-up telephone interviews. SETTING: Seven physical rehabilitation community occupational therapy clinics. PARTICIPANTS: Participants (N=178) with acute HI aged 22-65. Two participants were lost to follow-up. INTERVENTION: Not applicable. MAIN OUTCOME MEASURE: The dependent variable was TRTW. The independent variables originated from 4 domains: personal factors, environmental factors, body function and structure, and activity limitation and participation restriction. The proportion of return to work (RTW) at each time point was calculated. Multiple Cox regressions established a predictive model for TRTW. RESULTS: At the end of the study, 75.3% participants returned to work. The median TRTW was 94 days. In the final model, only compensation factors and education contributed significantly to overall RTW, but when separate analyses were performed, decreased level of self-efficacy, higher workplace demands, level of pain, level of emotional response to trauma, reduced physical capability of the hand, and higher level of disability were significantly associated with delayed TRTW. CONCLUSIONS: TRTW was determined by the physical capability of the hand, pain, and psychosocial factors, but it was also affected by legal factors. Participants who did not return to work during the first 9 months are at risk for long-term disability. Developing treatment programs for those who are at risk for not returning to work, taking into consideration these factors, is recommended.
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Traumatismos de la Mano/rehabilitación , Traumatismos Ocupacionales/rehabilitación , Reinserción al Trabajo/estadística & datos numéricos , Adulto , Anciano , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Terapia Ocupacional/estadística & datos numéricos , Modelos de Riesgos Proporcionales , Estudios Prospectivos , Autoeficacia , Encuestas y Cuestionarios , Factores de Tiempo , Resultado del Tratamiento , Evaluación de Capacidad de Trabajo , Adulto JovenRESUMEN
BACKGROUND: Asthma is a common respiratory disease, which is linked to air pollution. However, little is known about the effect of specific air pollution sources on asthma occurrence. OBJECTIVES: To assess individual asthma risk in three urban areas in Israel characterized by different primary sources of air pollution: predominantly traffic-related air pollution (Tel Aviv) or predominantly industrial air pollution (Haifa bay area and Hadera). METHODS: The medical records of 13,875, 16- 19-year-old males, who lived in the affected urban areas prior to their army recruitment and who underwent standard pre-military health examinations during 2012-2014, were examined. Nonparametric tests were applied to compare asthma prevalence, and binary logistic regressions were used to assess the asthma risk attributed to the residential locations of the subjects, controlling for confounders, such as socio-demographic status, body mass index, cognitive abilities, and education. RESULTS: The asthma rate among young males residing in Tel Aviv was 8.76%, compared to 6.96% in the Haifa bay area and 6.09% in Hadera. However, no statistically significant differences in asthma risk among the three urban areas was found in controlled logistic regressions (P > 0.20). This finding indicates that exposure to both industrial- and traffic-related air pollution is associated with asthma prevalence. CONCLUSIONS: Both industrial- and traffic-related air pollution have a negative effect on asthma risk in young males. Studies evaluating the association between asthma risk and specific air pollutants (e.g., sulfur dioxide, particulate matter, and nitrogen dioxide) are needed to ascertain the effects of individual air pollutants on asthma occurrence.
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Contaminación del Aire , Asma , Exposición a Riesgos Ambientales , Material Particulado , Emisiones de Vehículos , Adolescente , Contaminación del Aire/prevención & control , Contaminación del Aire/estadística & datos numéricos , Asma/diagnóstico , Asma/epidemiología , Asma/prevención & control , Exposición a Riesgos Ambientales/efectos adversos , Exposición a Riesgos Ambientales/análisis , Humanos , Israel/epidemiología , Masculino , Evaluación de Necesidades , Dióxido de Nitrógeno/efectos adversos , Dióxido de Nitrógeno/análisis , Material Particulado/efectos adversos , Material Particulado/análisis , Prevalencia , Medición de Riesgo , Factores de Riesgo , Salud Urbana/normas , Salud Urbana/estadística & datos numéricos , Emisiones de Vehículos/análisis , Emisiones de Vehículos/prevención & control , Adulto JovenRESUMEN
Numerous studies demonstrated that exposure to ambient air pollutants contributes to severity and frequency of asthma exacerbations. However, whether common air pollutants, such as nitrogen dioxide (NO2) and sulfur dioxide (SO2), exert differential effects on asthma occurrence and severity is unclear. The aim of this investigation was to determine whether exposure to NO2 and/or SO2 may initiate different long-term effects on prevalence and severity of asthma in young adults. Medical records of 137,040 males, 17 years old, who underwent standard premilitary service health examinations during 1999-2008 were examined. Air-pollution data for NO2 and SO2 were linked to the place of residence of each subject. The influence of specific air pollutants on asthma prevalence and severity was evaluated using bivariate logistic regression, controlling for individuals' sociodemographic attributes. For both ambient air pollutants, there was a significant dose-response effect on severity of asthma at ambient concentrations below the current National Ambient Air Quality Standards. However, in residential areas with high levels of SO2 (13.3-592.7µg/m(3)) and high levels of NO2 (27.2-43.2µg/m(3)) the risk of asthma occurrence was significantly higher than that in residential areas with high levels of NO2 (27.2-43.2 µg/m(3)) and intermediate levels (6.7-13.3 µg/m(3)) of SO2 pollution. The effects of exposure to SO2 and NO2 air pollutants on the respiratory airways system appear to differ, with possible implications regarding medical management, even in cases of exposure to mixtures of these pollutants.
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Contaminantes Atmosféricos/toxicidad , Asma/inducido químicamente , Asma/epidemiología , Exposición a Riesgos Ambientales , Dióxido de Nitrógeno/toxicidad , Dióxido de Azufre/toxicidad , Adolescente , Asma/diagnóstico , Humanos , Israel/epidemiología , Masculino , Prevalencia , Sistema Respiratorio/efectos de los fármacosRESUMEN
UNLABELLED: Background: Obstructive sleep apnea (OSA) is a common health problem with an estimated prevalence of 4% among men, many of whom are undiagnosed and untreated. OBJECTIVES: To compare demographic characteristics, health profiles, risk factors, and disease severity in Arab and Jewish men with OSA syndrome. METHODS: In this cross-sectional study we retrospectively analyzed clinical data from the medical files of men ≥ 22 years old who were referred to the Rambam Medical Center sleep clinic during the period 2001-2009 with a suspected diagnosis of OSA. OSA severity was measured using the apnea-hypopnea index (AHI). Categorical variables were compared using the chi-square test. Relations between OSA severity and a set of independent risk factors were assessed by linear regression analysis. RESULTS: A total of 207 men were included (39 Arabs, 19%; 168 Jews, 81%). Arab participants were younger than their Jewish counterparts (45.5 ± 8.9 years vs. 49.8 ± 11.8, P = 0.04) and their body mass index (BMI) was higher (3.1 ± 5.1 vs. 30.0 ± 4.4, P = 0.001). OSA severity (AHI score) was higher among Arab men, with low, medium and high severity scores seen in 10%, 33% and 56% of Arab men vs. 35%, 29% and 37% of Jewish men, respectively [T(198) = 2.39, P = 0.02]. Mean blood oxygen saturation was comparable. CONCLUSIONS: Arab men presenting for evaluation of sleep apnea harbored more severe OSA symptoms, were younger, and had higher BMI compared to Jewish men. Since OSA syndrome evolves for several years until it becomes severe, these findings suggest that Arab men seek medical assistance later than Jewish men with OSA.
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Apnea Obstructiva del Sueño , Adulto , Árabes/estadística & datos numéricos , Índice de Masa Corporal , Distribución de Chi-Cuadrado , Estudios Transversales , Humanos , Israel/epidemiología , Judíos/estadística & datos numéricos , Masculino , Persona de Mediana Edad , Polisomnografía/métodos , Prevalencia , Análisis de Regresión , Estudios Retrospectivos , Factores de Riesgo , Índice de Severidad de la Enfermedad , Apnea Obstructiva del Sueño/diagnóstico , Apnea Obstructiva del Sueño/etnología , Apnea Obstructiva del Sueño/fisiopatologíaRESUMEN
UNLABELLED: BACKGROUND/STUDY CONTEXT: The Work Ability Index (WAI) questionnaire is widely used for evaluation of the work ability of workers. This is the first application of the validated Hebrew version of this questionnaire to Israeli nurses in order to evaluate factors affecting their work ability. METHODS: A cross-sectional study was conducted among 515 nurses from two general hospitals in Israel (87.3% female). RESULTS: A significant negative correlation was found between the WAI score and age, years in current job, and number of reported diagnoses. The most frequently reported illnesses (as diagnosed by a physician) were musculoskeletal disorders, endocrine/metabolic diseases, and cardiovascular diseases. Agreement between illnesses as diagnosed by a physician and as self-reported by nurses was low, especially with respect to mental/emotional stress, (kappa statistics = 16.4%, p < .001). CONCLUSIONS: Mean WAI score found in Israeli hospital nurses is relatively high as compared with that of European nurses. It gradually decreases with age. The WAI questionnaire enables the early identification of those nurses with compromised work ability and who are in need of assistance in order to prevent early retirement. As retirement age is currently advancing, keeping elderly workers in the workforce is of prime importance.
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Enfermeras y Enfermeros , Encuestas y Cuestionarios , Evaluación de Capacidad de Trabajo , Adulto , Anciano , Envejecimiento , Femenino , Hospitales Generales , Humanos , Israel , Masculino , Persona de Mediana Edad , Adulto JovenRESUMEN
BACKGROUND: A worldwide epidemic of type 2 diabetes mellitus (T2DM) is in progress. This disease carries a heavy socioeconomic burden. OBJECTIVES: To compare the incidence rate of overall and site-specific cancers among Israeli Arabs with T2DM to that of Israeli Arabs without. METHODS: A retrospective cohort study of all adult Arab members of Clalit Health Care Services in northern Israel was conducted over a 10 year period (1999-2008). RESULTS: During the study period 752 and 2045 incident cases of cancer were diagnosed among 13,450 adults with diabetes and 74,484 without, respectively. The follow-up time involved 817,506 person-years. Diabetes was associated with a standard incidence ratio (SIR) of 3.27 (95% CI 1.49-5.05) and 2.87 (95% CI 1.25-4.50) for pancreatic cancer in men and women, respectively. A significantly reduced SIR (0.67, 95% CI 0.36-0.99) was observed for esophageal, stomach and intestinal cancers in men. CONCLUSIONS: Our findings support an association between T2DM and increased risk of cancer of the pancreas in Arab men and women. A significantly reduced risk of all other cancers was observed only in Arab men. Our findings underscore the need for effective diabetes and cancer prevention and intervention programs.
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Diabetes Mellitus Tipo 2/epidemiología , Neoplasias , Adulto , Factores de Edad , Anciano , Árabes , Bases de Datos Factuales/estadística & datos numéricos , Femenino , Estudios de Seguimiento , Humanos , Incidencia , Israel/epidemiología , Masculino , Persona de Mediana Edad , Neoplasias/clasificación , Neoplasias/epidemiología , Estudios Retrospectivos , Factores de Riesgo , Factores SexualesRESUMEN
BACKGROUND: From 2 to 5 December 2010, Israel experienced the most severe forest fire In its history, resulting in the deaths of rescue workers. Little research exists on the health risks to emergency responders during forest fires, and there is no published research to date on occupational health among firefighters in Israel. OBJECTIVES: To describe the exposures experienced by emer gency responders to smoke, fire retardants and stress; the utilization of protective equipment; and the frequency of corresponding symptoms during and following the Carmel Forest fire. METHODS: A cohort of 204 firfighers and 68 police who took part in rescue and fire-abating activites during the Carmel Forest fire were recruited from a representative sample of participating stations throughout the country and interviewed regarding their activities during the fire and their coinciding symptoms. Unpaired two-sample t-test compared mean exposures and symptom frequency for firefighters and police. Chi-square estimates of OR and 95%CI are provided for odds of reporting symptoms, incurring injury or being hospitalied for various risk factors RESULTS: Of the study participants, 87% reported having at least one symptom during rescue work at the Carmel Forest fire,with eye irritation (77%) and fatigue (71%) being the most comon. Occupational stress was extremely high during the fire; the average length of time working without rest was 18.4 hours among firefighters. CONCLUSION: Firefighter and police were exposed to smoke and ocupational stress prolonged periods during the fire. Further research is needed on the residual health effects from exposure to forest fires among emergency responders, and to identify areas for improvement in health preparedness.
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Bomberos/estadística & datos numéricos , Incendios/estadística & datos numéricos , Policia/estadística & datos numéricos , Lesión por Inhalación de Humo , Árboles , Adulto , Estudios de Cohortes , Femenino , Humanos , Israel/epidemiología , Masculino , Exposición Profesional/efectos adversos , Exposición Profesional/estadística & datos numéricos , Salud Laboral , Trabajo de Rescate/métodos , Trabajo de Rescate/estadística & datos numéricos , Dispositivos de Protección Respiratoria/clasificación , Dispositivos de Protección Respiratoria/estadística & datos numéricos , Factores de Riesgo , Humo/efectos adversos , Humo/análisis , Lesión por Inhalación de Humo/etiología , Lesión por Inhalación de Humo/mortalidad , Lesión por Inhalación de Humo/fisiopatología , Lesión por Inhalación de Humo/prevención & controlRESUMEN
The work ability questionnaire is widely used in many countries and for different groups of workers. We present the first use of the Hebrew translation of the questionnaire in a target group of community nurses. The calculated mean values of the index, using a standardized questionnaire, were compared with independent questions regarding various characteristics of work conditions and occupational stress. High correlations were found between mean work ability index (WAI) values and the independent questions attesting to the validity and usefulness of this simple tool for ascertaining the work ability of individual workers or as a research tool.
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Enfermeras y Enfermeros/psicología , Estrés Psicológico/diagnóstico , Encuestas y Cuestionarios , Evaluación de Capacidad de Trabajo , Adulto , Anciano , Femenino , Humanos , Israel , Lenguaje , Persona de Mediana Edad , Enfermedades Profesionales/diagnóstico , Salud Laboral , Adulto JovenRESUMEN
Occupational asthma (OA) is the most common of all occupational lung diseases in industrialized countries and its prevalence has been rising steadily. It is estimated that occupational factors account for one out of six cases of adult asthmatic patients causing significant morbidity, disability and costs. Due to its high prevalence and substantial health and socio-economic impacts OA represents a significant public health concern. OA can be divided into allergic and non allergic asthma. Allergic OA is further divided into IgE mediated and non IgE mediated. Baker's asthma (BA), is the leading cause of IgE mediated OA caused by high molecular weight antgens in industrialized countries. Innovations in the baking industry during the last few decades have led to the introduction of new allergens inducing OA. OA is potentially preventable, through early diagnosis and exposure cessation interventions. Thus, clinicians should consider the occupational history in every adult patient presenting with newly diagnosed asthma.
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Asma Ocupacional/epidemiología , Inmunoglobulina E/inmunología , Exposición Profesional/efectos adversos , Adulto , Antígenos/inmunología , Asma Ocupacional/inmunología , Asma Ocupacional/prevención & control , Costo de Enfermedad , Diagnóstico Precoz , Industria de Alimentos , Humanos , Peso Molecular , PrevalenciaRESUMEN
BACKGROUND: Although several studies have investigated the association of the Mediterranean diet (MD) with overall risk of specific cancers, data on overall cancer risk are sparse, especially in Arab populations. OBJECTIVES: To compare between the score of MD in cancer patients and cancer-free adult Israeli Arabs in order to identify risk factors amenable to intervention. METHODS: A case control study was conducted in northern Israel, involving 200 Arab subscribers of a regional Health Maintenance Organization (HMO). RESULTS: An inverse association was found (p = 0.000) between Mediterranean diet score and cancer, with OR = 0.4, 95% CI = 0.260-0.612. CONCLUSIONS: Greater adherence to Mediterranean diet is associated with lower prevalence of cancer. The adoption of this dietary pattern also seems to moderate the prevalence of obesity and risks of chronic diseases.
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Enfermedad Crónica , Dieta Mediterránea/etnología , Neoplasias , Obesidad , Adulto , Factores de Edad , Árabes , Estudios de Casos y Controles , Enfermedad Crónica/etnología , Enfermedad Crónica/prevención & control , Interpretación Estadística de Datos , Encuestas sobre Dietas , Femenino , Humanos , Israel/epidemiología , Masculino , Persona de Mediana Edad , Neoplasias/clasificación , Neoplasias/etnología , Neoplasias/etiología , Evaluación Nutricional , Obesidad/etnología , Obesidad/etiología , Prevalencia , Factores de Riesgo , Factores Sexuales , Factores SocioeconómicosRESUMEN
BACKGROUND: The Arab population of Israel is a separate ethnic group from the Jewish population, embracing a different lifestyle and different nutritional habits and environmental exposures. These variations may lead to dissimilar expressions of certain diseases in the Arab Israeli as compared with the Jewish population. In recent years, the Arab population in Israel has experienced rapid and marked changes toward westernization in lifestyle, and significant increases in the incidence rate of both diabetes mellitus (DM) and cancer This is combined with an increase in known risk factors common to both illnesses. METHODS: Review of recent publications and official health statistics provided the sources of information for this review. RESULTS: Studies show that in recent decades the incidence rate of DM in the Israeli Arab population has increased by 9.1 per 1000 persons annually and of cancer by 1.3 per 1000 person annually among males and by 1.2 per 1000 person among females. In contrast, these rates have decreased in the Jewish population. CONCLUSIONS: Lifestyle change in recent decades (westernization) in the Israeli Arab population has led to a marked increase in the incidence rate of DM and cancer in this group. The most influential risk factors are unhealthy diet, physical inactivity and tobacco smoking. By understanding these processes, effective intervention efforts can be initiated in order to reverse these trends.
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Árabes/estadística & datos numéricos , Diabetes Mellitus/epidemiología , Judíos/estadística & datos numéricos , Neoplasias/epidemiología , Diabetes Mellitus/etnología , Femenino , Humanos , Incidencia , Israel/epidemiología , Estilo de Vida/etnología , Masculino , Neoplasias/etnología , Factores de Riesgo , Factores SexualesRESUMEN
OBJECTIVE: A previous randomized controlled trial revealed that combined aerobic and neck-specific exercises yielded greater improvement than neck-specific exercises alone after a 6-month intervention in outpatients with nonspecific neck pain (NP). The aim of this secondary analysis was to identify subgroups of patients in the combined exercises group most likely to benefit from the intervention. METHODS: Sixty-nine patients were included. The original trial was conducted in multiple physical therapy outpatient clinics twice a week for 6 weeks; follow-up was 6 months after assignment. The primary outcome was the therapeutic success rate (Global Rating of Change Score ≥ +5, "quite a bit better") after 6 weeks of training and at the 6-month follow-up. Candidate predictors from patients' medical history and physical examination were selected for univariable regression analysis to determine their association with treatment response status. Multivariable logistic regression analysis was used to derive preliminary clinical prediction rules. RESULTS: The clinical prediction rule contained 3 predictor variables: (1) symptom duration ≤6 months, (2) neck flexor endurance ≥18 seconds, and (3) absence of referred pain (Nagelkerke R2 = .40 and -2 log likelihood = 60.30). The pre-test probability of success was 61.0% in the short term and 77.0% in the long term. The post-test probability of success for patients with at least 2 of the 3 predictor variables was 84.0% in the short term and 87.0% in the long term; such patients will likely benefit from this program. CONCLUSION: A simple 3-item assessment, derived from easily obtainable baseline data, can identify patients with NP who may respond best to combined aerobic and neck-specific exercises. Validation is required before clinical recommendation. IMPACT: Patients experiencing NP symptoms ≤6 months who have no referred pain and exhibit neck flexor endurance ≥18 seconds may benefit from a simple self-training program of combined aerobic and neck-specific exercises.
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Reglas de Decisión Clínica , Dolor de Cuello , Terapia por Ejercicio , Humanos , Cuello , Dolor de Cuello/rehabilitación , Modalidades de Fisioterapia , Resultado del TratamientoRESUMEN
BACKGROUND: Hand injuries (HI) are common and may limit participation in work. The objective of this study is to examine the effect of ethnicity and other prognostic variables on return-to-work (RTW) among male manual workers after acute HI. METHODS: A cohort of 178 subjects (90 Arabs, 88 Jews) aged 22 to 65 was studied. Trained bilingual occupational therapists evaluated and interviewed the subjects, using structured validated questionnaires for evaluating personal and environmental factors, body function and structure, and activity limitation and participation restrictions. Employment status 3 months post injury was assessed by a telephone interview. To establish a predictive model for RTW, ethnicity and certain variables of the four domains mentioned above were analyzed using logistic regression analysis. RESULTS: A significant difference in the rate of RTW between Jews and Arabs was found (45.5% for Jews, 28.9% for Arabs, p = 0.03) three months post HI. In the univariate regression analysis, ethnicity was associated with RTW (OR = 2.05; CI: 1.10-3.81) for Jews vs. Arabs. Using a multivariate analysis, only legal counseling, educational attainment, and the severity of disability were significantly associated with RTW. CONCLUSION: RTW three months post HI among manual workers is directly related to variables such as education and legal counseling and only indirectly related to ethnicity. Patients with a lower level of education and those who were engaged in legal counseling need special attention and close guidance in the process of RTW.
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Etnicidad/estadística & datos numéricos , Traumatismos de la Mano/etnología , Reinserción al Trabajo/estadística & datos numéricos , Adulto , Anciano , Estudios de Cohortes , Femenino , Humanos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Análisis de Regresión , Adulto JovenRESUMEN
AIM: Assess the prevalence of neoplasia ≥6â¯mm at repeat CT colonoscopy (CTC) in individuals with no significant lesions at baseline. METHODS: Individuals aged ≥18â¯years, with/without CRC risk factors, with no polyps ≥6â¯mm on baseline CTC (negative baseline) who underwent repeat CTC in a large HMO from 2001 to 2011 were retrospectively identified. Studies were reviewed by board-certified radiologists with experience interpreting CTC. Demographic details, CRC risk factors, and the number, size, and location of incident lesions were noted. Findings were classified using the C-RADS scale. Lesion prevalence at CTC-2 was determined, and study interval and risk characteristics of patients with- and without findings were compared. RESULTS: Our study included 636 individuals (369 men [58.0%]; mean age 59.9â¯years) with negative baseline CTC who underwent repeat CTC after a mean 4.6â¯year interval (SD 1.6â¯years). At baseline, 469/636 (73.7%) were at average risk for CRC; 418 remained at average risk for CTC-2 with 51 (8.0%) developing new risk factors in the interval between studies. At CTC-2, 47 participants (7.4%) presented 52 significant neoplasia: 35 polyps 6-9â¯mm, 14 polyps ≥10â¯mm, and 3 masses in 3/636 participants (0.47%). 2/3 masses, 6/14 polyps ≥10â¯mm (42.9%), and 12/25 polyps 6-9â¯mm (48.0%) were in individuals with risk factors for CRC. Histopathology was available for 12/52 lesions (23.1%): 8 tubular adenomas, 2 villous adenomas, 1 hamartomatous polyp, 1 case of normal tissue. CONCLUSION: A mean 4.6â¯years after negative-baseline CTC, neoplasia ≥6â¯mm were seen in 7.4% of participants, including masses in 0.47%, supporting recommendations for a 5-year study interval.
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Colon/patología , Neoplasias del Colon/patología , Pólipos del Colon , Adenoma/diagnóstico , Adenoma/diagnóstico por imagen , Adenoma/patología , Adulto , Anciano , Colon/diagnóstico por imagen , Neoplasias del Colon/diagnóstico , Neoplasias del Colon/diagnóstico por imagen , Pólipos del Colon/diagnóstico por imagen , Colonografía Tomográfica Computarizada/métodos , Colonoscopía , Femenino , Estudios de Seguimiento , Hamartoma/diagnóstico , Hamartoma/diagnóstico por imagen , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Estudios Retrospectivos , Factores de TiempoRESUMEN
BACKGROUND: Case-control studies remain an important study design for aetiologic research on cancer, particularly when cohorts are not available. In addition to the potential biases inherent in this design, conducting fieldwork in settings with weak health care and information systems for cancer, such as in sub Saharan Africa, confer additional challenges which we present here with the aim to share experience to guide future studies. METHODS: We undertook a hospital-based case-control study of squamous cell esophageal cancer at the Moi Teaching and Referral Hospital in Eldoret, West Kenya. Cases were recruited at endoscopy and controls from hospital wards, age and gender frequency-matched to cases. Urine, toenails, blood and tumour biopsy were collected and a questionnaire administered. RESULTS: During this pilot phase, 143 cases and 155 controls were successfully recruited. Complete questionnaire data was obtained through e-data collection. Biospecimen collection was possible with support of an already existing equipped laboratory. We introduce changes made in the main study phase, including on expansion of the control groups to allow to consideration of selection bias. CONCLUSIONS: Extra attention and funding to train and monitor data quality and biospecimen collection and collaboration of a large group held together by strong leadership are essential. We recommend studies based on regional treatment centres with their more defined catchment areas rather than in the capital cities as referral routes in multi-level health care systems are severely attrition prone.
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Estudios de Casos y Controles , Métodos Epidemiológicos , Neoplasias Esofágicas/epidemiología , Carcinoma de Células Escamosas de Esófago/epidemiología , Países en Desarrollo , Femenino , Humanos , Kenia/epidemiología , Masculino , Proyectos Piloto , Proyectos de Investigación , Encuestas y CuestionariosRESUMEN
This study was performed in order to demonstrate that non-occupational physicians are often unaware of the possible role of occupational risk factors in the multifactorial etiology of carpal tunnel syndrome (CTS). Study participants consisted of 229 individuals, 127 cases of CTS matched with 102 controls. In only 41% of the cases did family or attending physicians in the hospital asked the concerned patients about their occupation or specific job tasks, and less than 10% of the cases were referred for further evaluation to an occupational physician. Occupational risk factors that were identified were: work with repeated movements of the wrist (OR=2.15, 95% CI=1.14-4.07) and work in a cold environment (OR=3.52, 95% CI=1.08-11.47). By improving the awareness of clinicians (and patients) to the possible role of work-related factors in the etiology of CTS, appropriate preventive measures can be introduced in order to reduce the burden of this syndrome.
Asunto(s)
Síndrome del Túnel Carpiano/diagnóstico , Conocimientos, Actitudes y Práctica en Salud , Enfermedades Profesionales/diagnóstico , Médicos , Síndrome del Túnel Carpiano/etiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/etiología , Factores de RiesgoRESUMEN
PURPOSE: The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) questionnaire is used internationally to assess function and disability. The instrument has been translated into several languages, but no Hebrew version exists. The objective of this study was to evaluate the use of the 12-item WHODAS 2.0 questionnaire among Hebrew speakers with and without hand injuries (HI). METHODS: The translated questionnaire was conducted among 155 uninjured subjects (UI) and 77 male workers with HI. Internal consistency was assessed using Cronbach's alpha. Test-retest reliability was assessed in UI subjects and calculated using the intraclass correlation coefficient (ICCagreement). Validity was evaluated by correlating the 12-item WHODAS 2.0 to the short-form of health survey (SF-12) in UI subjects and comparing the 12-item WHODAS 2.0 scores and the Quick Disability of Arm, Shoulder, and Hand (QDASH) Outcome Measure in the HI group. RESULTS: The Cronbach's alpha of the WHODAS 2.0 for the entire sample was α = 0.83. The ICCagreement for test-retest reliability was 0.88. A positive significant correlation was found between the 12-item WHODAS 2.0 and the QDASH (rs = 0.53, p < .005). CONCLUSIONS: The results support the reliability and validity of this Hebrew translation of the 12-item WHODAS 2.0. IMPLICATIONS FOR REHABILITATION Measurement tools that assess activities and participation after HI are an essential part of the rehabilitation process. The 12-item WHODAS 2.0 is a useful tool, since it addresses a broader range of activity and participation domains compared to the DASH and enables better implementation of the ICF model. Since the WHODAS 2.0 does not target a specific disease (as oppose to the DASH), it can be used to compare disabilities caused by different diseases or traumas. The WHODAS 2.0 measures both the function and disability in general populations as well as clinical situations; therefore, the instrument is useful for assessing both health and disability.
Asunto(s)
Comparación Transcultural , Evaluación de la Discapacidad , Personas con Discapacidad/rehabilitación , Traumatismos de la Mano/rehabilitación , Encuestas y Cuestionarios/normas , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Israel , Lenguaje , Masculino , Persona de Mediana Edad , Reproducibilidad de los Resultados , Participación Social , Organización Mundial de la Salud , Adulto JovenRESUMEN
We aim to demonstrate on the example of recent Palestinian-Israeli collaborative projects how sustainable cooperation can be achieved despite unfavorable political atmosphere and continuing violent disputes. Palestinian and Israeli participants of the collaborative projects declared that their attitude and belief in coexistence was positively changed as a result of their experience in cooperative work. Their main motivations were a desire to contribute to the resolution of the conflict and to improve professional skills. The experience in Israeli-Palestinian conflict showed that the collaborative projects of higher chance of success and sustainability should address issues of high priority to the concerned parties, lead to demonstrable benefits in the immediate future, and preferably be organized by non-governmental organizations. Also, to secure long-term success of collaborative projects, parity and symmetry should be maintained, as well as equal division of work and responsibility between the partners. Collaboration in public health field is first to be (re)established in conflict areas to alleviate suffering, minimize future health risks, and prevent further health deterioration. Thereby, public health can serve as a bridge to peace in areas of unrest or war.