RESUMEN
One of the characteristics of the cerebral aging process is the presence of chronic inflammation through glial cells, which is particularly significant in neurodegeneration. On the other hand, it has been demonstrated that the aryl hydrocarbon receptor (AHR) participates in the inflammatory response. Currently, evidence in animal models shows that the hallmarks of aging are associated with changes in the AHR levels. However, there is no information concerning the behavior and participation of AHR in the human aging brain or in Alzheimer's disease (AD). We evaluated the expression of AHR in human hippocampal post-mortem tissue and its association with reactive astrocytes by immunohistochemistry. Besides this, we analyzed through ELISA the AHR levels in blood serum from young and elder participants, and from AD patients. The levels of AHR and glial fibrillar acid protein were higher in elder than in young post-mortem brain samples. AHR was localized mainly in the cytosol of astrocytes and displayed a pattern that resembles extracellular vesicles; this latter feature was more conspicuous in AD subjects. We found higher serum levels of AHR in AD patients than in the other participants. These results suggest that AHR participates in the aging process, and probably in the development of neurodegenerative diseases like AD.
Asunto(s)
Enfermedad de Alzheimer/metabolismo , Astrocitos/metabolismo , Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/análisis , Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/sangre , Hipocampo/metabolismo , Receptores de Hidrocarburo de Aril/análisis , Receptores de Hidrocarburo de Aril/sangre , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Envejecimiento/fisiología , Animales , Ensayo de Inmunoadsorción Enzimática , Vesículas Extracelulares/metabolismo , Femenino , Proteína Ácida Fibrilar de la Glía/análisis , Humanos , Inmunohistoquímica , Masculino , Ratones , Ratones Endogámicos C57BL , Persona de Mediana Edad , Adulto JovenAsunto(s)
Neoplasias Óseas/patología , Quistes del Sistema Nervioso Central/patología , Silla Turca/patología , Adulto , Neoplasias Óseas/cirugía , Quistes del Sistema Nervioso Central/cirugía , Resultado Fatal , Humanos , Hipotálamo/patología , Masculino , Complicaciones Posoperatorias , Silla Turca/cirugíaRESUMEN
En este artículo se revisan criticamente los conceptos actuales de las condiciones clínicas y lesiones patológicas precursoras del carcinoma colo-rectal tales como los factores genéticos, ambientales, enfermedades inflamatorias crónicas y presencia de polipos displásicos .