RESUMEN
Inflammation and duodenal ulcers can meet many etiologies. We report the case of a young adult with an ulcerated duodenitis revealing Henoch-Schönlein purpura. The abdominal symptoms preceded the emergence of the classical cutaneous signs of the disease.
Asunto(s)
Úlcera Duodenal/diagnóstico , Duodenitis/diagnóstico , Vasculitis por IgA/diagnóstico , Adulto , Diagnóstico Diferencial , Úlcera Duodenal/etiología , Úlcera Duodenal/patología , Duodenitis/etiología , Duodenitis/patología , Humanos , Vasculitis por IgA/complicaciones , Vasculitis por IgA/patología , Masculino , Adulto JovenRESUMEN
Electron impact dissociation of protonated and deuterated nitrogen ions has been studied using a crossed beams apparatus. Absolute cross sections for dissociation channels producing N(+) and NH(+), respectively, are presented. The observations of subthreshold signals in these measurements indicate the presence of ro-vibrationally and possibly electronically excited states in the parent ions. Comparisons with other measurements are given.
RESUMEN
The human c-myc proto-oncogene is transcribed from four alternative promoters (P0, P1, P2, and P3) giving rise to mRNAs having 5' leader sequences of various length. The c-myc P0 mRNA contains three open reading frames (ORFs), the last one encoding c-Myc1 and c-Myc2 proteins generated by alternative translation initiated at CUG and AUG codons. The middle ORF (MYCHEX1) and the 5' ORF (ORF1) code for proteins 188 and 114 amino acids in length, respectively. We and others previously identified an internal ribosome entry site (IRES) in P0 and P2 c-myc mRNAs, promoting the cap-independent translation of c-Myc1 and c-Myc2. Here, we report the presence of a second IRES (named IRES1) promoting the cap-independent translation of MYCHEX1 in c-myc P0 mRNA. Using deletion analysis, we mapped an 80-nt region essential for IRES1 activity. c-myc P0 mRNA is thus the first eukaryotic polycistronic mRNA described for which translation initiation of two different open reading frames (MYCHEX1 and c-Myc1/c-Myc2) involves internal ribosome entry.
Asunto(s)
Genes myc , Biosíntesis de Proteínas , ARN Mensajero/genética , Ribosomas/genética , Regiones no Traducidas 5' , Secuencia de Bases , Codón , Cartilla de ADN , Células HeLa , Humanos , Sistemas de Lectura Abierta , Proto-Oncogenes MasRESUMEN
In a randomized, double-blind, placebo-controlled study, 32 patients with nonulcer dyspepsia received 5 mg of cisapride or placebo three times daily for four weeks after a two-week run-in phase on placebo. Limited antacid use was allowed. Cisapride was superior to placebo in reducing the intensity of epigastric pain at two weeks (P = 0.03) and four weeks (P = 0.01). At the end of treatment, 82% of the cisapride-treated patients and 43% of the controls had no or only mild pain. Minor, gastrointestinal side effects were observed in two cisapride-treated patients and in one control.
Asunto(s)
Dispepsia/tratamiento farmacológico , Dolor/tratamiento farmacológico , Piperidinas/uso terapéutico , Antagonistas de la Serotonina/uso terapéutico , Adulto , Antiácidos/administración & dosificación , Antiácidos/uso terapéutico , Cisaprida , Ensayos Clínicos como Asunto , Método Doble Ciego , Dispepsia/complicaciones , Femenino , Humanos , Masculino , Dolor/etiología , Distribución Aleatoria , Factores de TiempoRESUMEN
On the basis of a new case of Salazopyrine hypersensitivity pneumonitis, the authors describe the value of bronchoalveolar lavage and of the lymphoblast transformation test. They also describe the difficulties in making the diagnosis of such pathology and review the various possible differential diagnoses in their patient.
Asunto(s)
Alveolitis Alérgica Extrínseca/inducido químicamente , Glucosamina/análogos & derivados , Sulfasalazina/efectos adversos , Alveolitis Alérgica Extrínseca/diagnóstico , Colitis Ulcerosa/tratamiento farmacológico , Combinación de Medicamentos/efectos adversos , Femenino , Glucosamina/efectos adversos , Humanos , Persona de Mediana EdadRESUMEN
BACKGROUND AND AIM: Hepatitis C virus genotype 2 is the third in order of frequency in Belgium. The aim of this study was to better define the genotype 2 carriers' epidemiology characteristics. METHODS: In a database comprising 1726 viremic hepatitis C virus patient from the south part of Belgium, the files of 98 genotype 2 carriers were reviewed. RESULTS: There was a strong association between genotype 2 and the mode of transmission. The rate of contamination by invasive medical exams was very high (23%), and statistically different from the one of the others genotypes. Eligibility for antiviral therapies and the rate of sustained viral response were high. CONCLUSION: HCV genotype 2 was highly associated with transmission by invasive medical exams.
Asunto(s)
Hepacivirus/genética , Hepatitis C/diagnóstico , ARN Viral/genética , Bélgica/epidemiología , Femenino , Genotipo , Hepatitis C/epidemiología , Hepatitis C/virología , Humanos , Masculino , Persona de Mediana Edad , Morbilidad/tendencias , Estudios Retrospectivos , Factores de RiesgoAsunto(s)
Cateterismo Cardíaco , Cardiopatías/diagnóstico , Enfermedades Pulmonares/diagnóstico , Adolescente , Adulto , Anciano , Niño , Humanos , Masculino , Persona de Mediana EdadAsunto(s)
Enfermedades Gastrointestinales , Adulto , Anciano , Colon/anomalías , Quistes , Femenino , Hemorroides , Humanos , Hepatopatías , Masculino , Persona de Mediana Edad , PancreatitisAsunto(s)
Colon Sigmoide/cirugía , Neumatosis Cistoide Intestinal/diagnóstico , Sulfato de Bario , Biopsia , Colectomía , Diarrea/etiología , Flatulencia/etiología , Humanos , Masculino , Persona de Mediana Edad , Neumatosis Cistoide Intestinal/diagnóstico por imagen , Neumatosis Cistoide Intestinal/patología , Neumatosis Cistoide Intestinal/cirugía , Proctoscopía , Radiografía , SigmoidoscopíaAsunto(s)
Amiodarona/efectos adversos , Pulmón/efectos de los fármacos , Fibrosis Pulmonar/inducido químicamente , Humanos , Pulmón/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Capacidad de Difusión Pulmonar , Fibrosis Pulmonar/diagnóstico por imagen , Fibrosis Pulmonar/fisiopatología , RadiografíaRESUMEN
We studied 40 patients with irritable bowel syndrome (IBS) which received in a simple-blind fashion otilonium and pinaverium bromide (15 days each drug). During each 15-day period we evaluated: number of pain episodes, intensity of pain, number of bowel movements, side effects. Otilonium bromide, (OB), compared with pinaverium bromide was able to significantly (p less than 0.05) reduce the number of pain attacks, whereas no significant differences were found between the 2 groups as regards the other parameters. The occurrence of side effects was similar in the two treatment courses. We can conclude that the two types of treatment were similarly useful in IBS, although OB seems more effective than pinaverium bromide.
Asunto(s)
Enfermedades Funcionales del Colon/tratamiento farmacológico , Morfolinas/uso terapéutico , Parasimpatolíticos/uso terapéutico , Compuestos de Amonio Cuaternario/uso terapéutico , Dolor Abdominal/tratamiento farmacológico , Tolerancia a Medicamentos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Método Simple CiegoRESUMEN
On chest radiograph, the diagnosis of tracheobronchial tear is usually suspected because of the persistence of a pneumothorax after chest tube insertion. Since this radiographic pattern is nonspecific, the diagnosis is usually made by bronchoscopy and delayed. The fallen-lung sign consists in the fall of the collapsed lung away from the mediastinum occurring when the normal central bronchial anchoring attachment of the lung is disrupted. In contrast to the persistent pneumothorax, this sign is specific but rarely observed. Our purpose is to present the corresponding CT patterns observed in two cases of right stem bronchus tear, consisting in a caudal-dependent displacement of the right upper lobe bronchus which becomes obliquely oriented.