RESUMEN
The article "Imipenem-resistance in Serratia marcescens is mediated by plasmid expression of KPC-2", by W.-Q. Su, Y.-Q. Zhu, N.-M. Deng, L. Li, published in Eur Rev Med Pharmacol Sci 2017; 21 (7): 1690- 1694-PMID: 28429335 has been retracted by the Editor in Chief. Following some concerns raised on PubPeer (link: https://pubpeer.com/publications/F7E91E2863540C7CB030B86E16917F), the Editor in Chief has started an investigation to assess the validity of the results as well as possible figure and data manipulation. The authors were informed about the journal's investigation but have remained unresponsive and have not provided the manuscript's raw data. Therefore, the validity of the overall results could not be verified. The journal's investigation revealed that Figures 2 and 3 have been computer-generated. Additionally, Figure 1 was duplicated from a previously published article. Moreover, several terminology inaccuracies were identified within the manuscript. Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/12540.
RESUMEN
OBJECTIVE: Imipenem is a broad-spectrum carbapenem antibiotic with applications against severe bacterial infections. Here, we describe the identification of imipenem-resistant Serratia marcescens in our hospital and the role of plasmid-mediated KPC-2 expression in imipenem resistance. MATERIALS AND METHODS: We used the modified Hodge test to detect carbapenemase produced in imipenem-resistant strains. RESULTS: His resistance can be transferred to E. coli in co-culture tests, which implicates the plasmid in imipenem resistance. PCR amplification from the plasmid identified two products consistent with KPC-2 of 583 and 1050 bp that were also present in E. coli after co-culture. The restriction pattern for both plasmids was identical, supporting the transfer from the S. marcescens isolate to E. coli. Finally, gene sequencing confirmed KPC-2 in the plasmid. CONCLUSIONS: Due to the presence of KPC-2 in the imipenem-resistant S. marcescens, we propose that KPC-2 mediates antibiotic resistance in the S. marcescens isolate.