RESUMEN
The most commonly identified pathogens related to bacterial meningitis are group B streptococcus and gram-negative enteric flora; anaerobic sepsis and meningitis are very rare. We report a case on a preterm and extremely low-birth weight infant who developed meningitis caused by Bacteroides fragilis and his mother who had postpartum sepsis also caused by the same agent.
Asunto(s)
Bacterias Anaerobias , Bacteroides fragilis , Meningitis Bacterianas/diagnóstico , Meningitis Bacterianas/microbiología , Adulto , Antibacterianos/farmacología , Antibacterianos/uso terapéutico , Bacteroides fragilis/efectos de los fármacos , Biomarcadores , Femenino , Humanos , Recién Nacido , Meningitis Bacterianas/complicaciones , Meningitis Bacterianas/tratamiento farmacológico , Pruebas de Sensibilidad Microbiana , Evaluación de Síntomas , Resultado del TratamientoRESUMEN
The majority of coronavirus disease 2019 (COVID-19) have been confirmed in adults, with only a few reported cases in children. In the pediatric population, COVID-19 infection appears to be often unremarkable or associated with mild respiratory symptoms. Little is known about neurologic complications related to COVID-19 in newborns. We present a case of severe encephalitis with cytotoxic brain edema in a newborn with COVID-19.
Asunto(s)
Edema Encefálico/patología , Edema Encefálico/virología , Encéfalo/patología , COVID-19/complicaciones , Encefalitis Viral/etiología , Enfermedad Aguda , Encéfalo/diagnóstico por imagen , Encéfalo/virología , Edema Encefálico/diagnóstico por imagen , COVID-19/diagnóstico , Femenino , Humanos , Recién Nacido , Transmisión Vertical de Enfermedad Infecciosa , Imagen por Resonancia Magnética , Masculino , Embarazo , Complicaciones Infecciosas del Embarazo/virología , Convulsiones/virologíaRESUMEN
BACKGROUND: There are few reports of miscarriages or stillbirths in women infected with SARS-CoV-2. We present five consecutive cases of fetal death (≥12 weeks) without other putative causes in women with laboratory-confirmed (RT-PCR) COVID-19 managed in a single Brazilian institution. CASE SERIES: All five women were outpatients with mild or moderate forms of COVID-19 and were not taking any medication. Four were nulliparous, all were overweight or obese, and none had any comorbidities or pregnancy complications that could contribute to fetal demise. Fetal death occurred at 21-38 weeks of gestation, on COVID-days 1-22. SARS-Cov-2 was detected by RT-PCR in amniotic fluid in one case and in placental specimens in two cases. All five women had acute chorioamnionitis on placental histology, massive deposition of fibrin, mixed intervillitis/villitis, and intense neutrophil and lymphocyte infiltration. One fetus had neutrophils inside alveolar spaces, suggestive of fetal infection. CONCLUSIONS: These five cases of fetal demise in women with confirmed COVID-19 without any other significant clinical or obstetric disorders suggest that fetal death can be an outcome of SARS-CoV-2 infection in pregnancy. The intense placental inflammatory reaction in all five cases raises the possibility of a direct effect of SARS-CoV-2 on the placenta.
RESUMEN
BACKGROUND: The occurrence of a respiratory syncytial virus (RSV) outbreak in a Neonatal Intensive Care Unit (NICU) is related to unfavorable outcomes, as this infection can lead to respiratory distress and death in premature in infants. Report the successful control of an outbreak that occurred in April 2010 in a NICU. METHODS: After the index case, of 18 premature infants placed in the same room 10 infants were infected. Of those 10, 6 developed mild to moderate respiratory symptoms, 4 persisted asymptomatic and no death occurred. Contact and respiratory precautions were rapidly initiated, the infants were cohorted in 3 different rooms and palivizumab was administered to all contacts. RESULTS: The outbreak was controlled and no new cases were subsequently indentified. CONCLUSION: Standard infection control measures plus palivizumab prophylaxis were efficient in rapid control of the outbreak.