The Influence of Fixed Dental Prostheses on the Expression of Inflammatory Markers and Periodontal Status-Narrative Review.

A dental prosthesis will only be successful if the restoration lasts for a long period and does not cause any illness. The presence of permanent prosthetic restorations has been linked to an increased risk of periodontal infections, according to a large body of research that has been gathered. When chronic inflammation is brought on by fixed prosthetic constructions, both cellular and noncellular immunity are activated as adaptive immune mechanisms. It has previously been stated that both clinically adequate and inadequate restorations might cause gingival inflammation. Areas surrounding the abutment teeth presented periodontal pockets, attachment loss, congestion, bleeding on probing, and gingival hyperplasia after fixed restorations were removed. The depth of pockets, bleeding on probing, and bone loss are all closely correlated with disease's severity and IL-1ß concentration in gingival crevicular fluid; IL-1ß shows higher values in disease sites than in healthy ones. hs-CRP and TNF-α blood levels showed a considerable reduction one day after fixed restorations were applied, in comparison with the pre-treatment values. Collaboration between prosthodontists and periodontists is essential for a good treatment outcome since it will increase the restoration's lifespan, enhance periodontal health, and improve the quality of life for dental patients.

Comparative Statistical Analysis of Key Performance Indicators in the Health System.

In this paper, a comparative statistical analysis of some performance indicators from the health system at SCJU Craiova and SJU Slatina is made in the period 2010-2021. Also, the correlations between the average duration of hospitalization, the bed utilization rate, the number of cases and the case complexity index for each hospital are studied. It is found that there are similarities, but also statistically significant differences between the two analyzed hospitals. Thus, it turns out that there are no significant differences between the bed utilization rate and the complexity index between the two hospitals, but there are statistically significant differences at a significance threshold of 5% between the average duration of hospitalization and the number of cases registered at the two hospitals analyzed. Moreover, the case complexity index is strongly negatively correlated with the bed utilization rate and with the number of cases in both hospitals, but positively correlated with the average duration of hospitalization at SCJU Craiova and weakly negatively correlated at SJU Slatina.

P53, p16 and Ki67 immunoexpression in oral squamous carcinomas.

In this study, we have analyzed clinically, histopathologically and immunohistochemically a total of 34 cases of oral squamous carcinoma in 11 of the cases being identified adjacent epithelial dysplastic lesions. Carcinomas were diagnosed in patients aged 40-60 years, males, with chronic exposure to tobacco and/or alcohol, being located especially on the lips. Well-differentiated carcinomas have been predominant (52.9%) in stage I/II tumoral (88.3%). Immunoexpression analysis of p53, p16 and Ki67 did not reveal statistically significant differences between the expression of markers and clinical or histopathological parameters, except Ki67 whose increased expression was associated to the decrease of the degree of tumoral differentiation and with high degree dysplasia. The positivity index and the intensity of reaction were increased at the level of dysplasic epithelium for p16 and at the level of tumoral invasion front for the p53 and Ki67. The study highlights the value of the immunostain for p16 in identifying dysplasic lesions and predictive importance of p53 and Ki67 markers in identifying the aggressive forms of oral carcinomas.