1.
Bioorg Med Chem Lett
; 21(6): 1741-3, 2011 Mar 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-21316228
RESUMEN
A series of N-(pyrimidin-4-yl)-phenylalanine VLA-4 antagonists is described. Optimization of substituents at the 2 and 5 positions of the pyrimidine ring gave 14, a very potent VLA-4 inhibitor which is orally active in a sheep asthma model.
Asunto(s)
Asma/tratamiento farmacológico , Modelos Animales de Enfermedad , Integrina alfa4beta1/antagonistas & inhibidores , Pirimidinas/uso terapéutico , Administración Oral , Animales , Asma/metabolismo , Disponibilidad Biológica , Descubrimiento de Drogas , Pirimidinas/farmacocinética , Ovinos
2.
AIDS
; 27(8): 1353-6, 2013 May 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23462216
RESUMEN
We examined the relationship between plasma adipokine concentrations and ultrasound measures of vascular health in 100 HIV-infected adults on antiretroviral therapy. Leptin was positively correlated with flow-mediated dilation of the brachial artery and negatively with carotid intima-media thickness. These relationships were independent of traditional risk factors and trunk fat in women but not men. Neither adiponectin nor resistin was associated with either measure of vascular health.