1.
Bioorg Med Chem Lett
; 14(1): 235-8, 2004 Jan 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-14684334
RESUMEN
Over 50 phenyl thiazolyl urea and carbamate derivatives were synthesized for evaluation as new inhibitors of bacterial cell-wall biosynthesis. Many of them demonstrated good activity against MurA and MurB and gram-positive bacteria including MRSA, VRE and PRSP. 3,4-Difluorophenyl 5-cyanothiazolylurea (3p) with clog P of 2.64 demonstrated antibacterial activity against both gram-positive and gram-negative bacteria.