RESUMEN
BACKGROUND: Persons living at high altitude (exposed to hypoxia) have a greater number of coronary and peripheral branches in the heart than persons living at sea level. In this study we investigated the effect of intermittent hypobaric hypoxia on myocardial perfusion in patients with coronary heart disease. METHODS AND RESULTS: We studied 6 male patients (aged>or=53 years) with severe stable coronary heart disease. All patients were born at sea level and lived in that environment. They underwent 14 sessions of exposure to intermittent hypobaric hypoxia (equivalent to a simulated altitude of 4200 m). Myocardial perfusion was assessed at baseline and after treatment with hypoxia by use of exercise perfusion imaging with technetium 99m sestamibi. After the sessions of hypoxia, myocardial perfusion was significantly improved. The summed stress score for hypoperfusion, in arbitrary units, decreased from 9.5+ to 4.5+ after treatment (P=.036). There was no evidence of impairment of myocardial perfusion in any patient after treatment. CONCLUSIONS: Intermittent hypobaric hypoxia improved myocardial perfusion in patients with severe coronary heart disease. Though preliminary, our results suggest that exposure to intermittent hypobaric hypoxia could be an alternative for the management of patients with chronic coronary heart disease.
Asunto(s)
Enfermedad de la Arteria Coronaria/diagnóstico por imagen , Enfermedad de la Arteria Coronaria/terapia , Oxigenoterapia Hiperbárica/métodos , Tecnecio Tc 99m Sestamibi , Disfunción Ventricular Izquierda/diagnóstico por imagen , Disfunción Ventricular Izquierda/prevención & control , Enfermedad Crónica , Enfermedad de la Arteria Coronaria/complicaciones , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , Cintigrafía , Radiofármacos , Resultado del Tratamiento , Disfunción Ventricular Izquierda/complicacionesRESUMEN
Main objetive of the present investigation were evaluate the impact of the simulated hypoxia technique - hypobaric chamber - to rehabilitate coronary bypassed patients with or without myocardial infarction. The following variable, pre and post rehabiliation four months program were explored: myocardial ischemia, arrythmia, late potencials, myocardium perfussion and molecular biochemistry. The last two were observed in a follow up of four months. results, shows general improvement. The follow up items, remained improved until protocol finish. Exercise was not utilized. Findigs are consider principally related to hypoxia. Mainly due to central rather than pheriphery recoveries.