Cervical diskography: analysis of provoked responses at C2-C3, C3-C4, and C4-C5.

BACKGROUND AND PURPOSE: Previous authors have described the locations of provoked responses to cervical diskography from C3-C4 to C6-C7, but we have found no description of the findings at C2-C3. This study was undertaken to analyze the sensations provoked during cervical diskography at C2-C3 and to compare the results with those provoked at C3-C4 and C4-C5. METHODS: The locations of diskographically provoked responses from 40 consecutive patients who had undergone C2-C3, C3-C4, and C4-C5 diskography were analyzed. Only intensely painful (> or = 7/10) and concordant responses were considered. Disk morphology on MR images and diskograms was also compared with the provoked responses. RESULTS: Eighteen subjects described either unilateral (n = 10) or bilateral (usually asymmetric) (n = 8) concordant pain at the craniovertebral junction in response to C2-C3 diskography. Nine subjects described either unilateral (n = 5) or bilateral (n = 4) neck pain during injection. Cephalalgia or head pain was provoked in 19 subjects, seven bilaterally. Four subjects described either unilateral (n = 3) or bilateral (n = 1) trapezius muscle and/or shoulder pain. Preliminary MR studies were not helpful, as most C2-C3 disks either appeared normal or exhibited nonspecific signs of degeneration. All disks exhibited either fissuring or extradiskal leakage of contrast material at diskography, regardless of the response provoked. CONCLUSION: Diskography at C2-C3 and C3-C4 frequently produces pain sensations in the head, craniovertebral junction, and neck. There is no correlation between C2-C3 disk morphology and the diskographically provoked response.

Magnetic resonance imaging of the thoracic spine. Evaluation of asymptomatic individuals.

We reviewed magnetic resonance imaging studies of the thoracic spines of ninety asymptomatic individuals to determine the prevalence of abnormal anatomical findings. This group included sixty individuals who had no history of any thoracic or lumbar pain and thirty individuals who had a history of low-back pain only. In addition, we reviewed imaging studies of eighteen patients who had an operatively proved herniation of a thoracic disc and studies of thirty-one patients who had been seen with thoracic pain. Sagittal T1-weighted spin-echo and axial multiplanar gradient refocused images at each disc level were interpreted by us (two neuroradiologists and two orthopaedic spine surgeons); we had no clinical information about the patients. Sixty-six (73 percent) of the ninety asymptomatic individuals had positive anatomical findings at one level or more. These findings included herniation of a disc in thirty-three subjects (37 percent), bulging of a disc in forty-eight (53 percent), an annular tear in fifty-two (58 percent), deformation of the spinal cord in twenty-six (29 percent), and Scheuermann end-plate irregularities or kyphosis in thirty-four (38 percent). This study documents the high prevalence of anatomical irregularities, including herniation of a disc and deformation of the spinal cord, on the magnetic resonance images of the thoracic spine in asymptomatic individuals. We emphasize that these findings represent roentgenographic abnormalities only, and any clinical decisions concerning the treatment of pain in the thoracic spine usually require additional studies.

Fungal infections of the spine. Report of eleven patients with long-term follow-up.

BACKGROUND: Fungal infections of the spine are noncaseating, acid-fast-negative infections that occur primarily as opportunistic infections in immunocompromised patients. We analyzed eleven patients with spinal osteomyelitis caused by a fungus, and we developed suggestions for treatment. METHODS: All patients with a fungal infection of the spine treated by the authors over a sixteen-year period at three teaching institutions were evaluated. There was a total of eleven patients. Medical records and roentgenograms were available for every patient. Long-term follow-up of the nine surviving patients was performed by direct examination by the authors or by the patient's primary physician. RESULTS: For ten of the eleven patients, the average delay in the diagnosis was ninety-nine days. Nine patients were immunocompromised secondary to diabetes mellitus, corticosteroid use, chemotherapy for a tumor, or malnutrition. The sources of the spinal infections included direct implantation from trauma (one patient), hematogenous spread (four patients), and local extension (two patients). The infection followed elective spine surgery in three patients, and the cause was unknown in one. Paralysis secondary to the spine infection developed in eight patients. Ten patients were treated with surgical debridement. All eleven patients were treated with systemic antifungal medications for a minimum of six weeks. One patient died of generalized sepsis at thirty-three days, and another patient died of gastrointestinal hemorrhage at five months. After an average of 6.3 years of follow-up, the infection had resolved in all nine surviving patients. CONCLUSIONS: Treatment of fungal spondylitis is often delayed because of difficulty with the diagnosis. Delay in the diagnosis led to poorer results in terms of neurologic recovery in our study. Performing fungal cultures whenever a spinal infection is suspected might hasten the diagnosis. Patients should be given a guarded prognosis and informed of the many possible complications of the disease.

Anterior decompression, structural bone grafting, and Caspar plate stabilization for unstable cervical spine fractures and/or dislocations.

Fourteen patients who sustained acute cervical spine fractures and/or dislocations with associated posterior ligamentous disruption had anterior decompressions, structural bone grafting, and anterior Caspar plate stabilization. With an average 30-month follow-up, no patient has had loss of fixation. Despite criticism raised from biomechanical testing, the Caspar anterior plate system (Aesculape, Tuttlingen, Germany) may be added to structural bone grafting of unstable cervical fractures and/or dislocations, yielding an in vivo solid construct, which obviates the need for simultaneous posterior stabilization.

A prospective, randomized, double-blind evaluation of trigger-point injection therapy for low-back pain.

The efficacy of trigger-point injection therapy in treatment of low-back strain was evaluated in a prospective, randomized, double-blind study. The patient population consisted of 63 individuals with low-back strain. Patients with this diagnosis had nonradiating low-back pain, normal neurologic examination, absence of tension signs, and lumbosacral roentgenograms interpreted as being within normal limits. They were treated conservatively for 4 weeks before entering the study. Injection therapy was of four different types: lidocaine, lidocaine combined with a steroid, acupuncture, and vapocoolant spray with acupressure. Results indicated that therapy without injected medication (63% improvement rate) was at least as effective as therapy with drug injection (42% improvement rate), at a P value of 0.09. Trigger-point therapy seems to be a useful adjunct in treatment of low-back strain. The injected substance apparently is not the critical factor, since direct mechanical stimulus to the trigger-point seems to give symptomatic relief equal to that of treatment with various types of injected medication.

Biomechanical analysis of facet and graft loading in a Smith-Robinson type cervical spine model.

OBJECTIVE: This study determined the effect of change in graft height on the forces across a Smith-Robinson graft as well as across the posterior elements of the same motion segment. STUDY DESIGN: The study utilizes a strain gauge technique for the measurement of facet joint loading and a subminiature load cell for the measurement of graft loads. SUMMARY OF BACKGROUND DATA: A number of cases of Smith-Robinson procedures have had some form of collapse of the interspace and graft material after surgery. Some patients with collapse of the graft go on to have prolonged sclerotomal-type pain or pseudarthrosis. The appropriate amount of distraction is not well defined in the literature and may affect the outcome. METHODS: Cervical spines (C5-C6) were instrumented by placing strain gauges bilaterally on the pedicles of C6 (to measure the forces across the posterior elements). A miniature load cell with matching metallic shims was used to measure the force across the graft site and to distract the segment. Forces across the posterior elements and the graft site were measured, during flexion loading, and compared as the disc space was distracted. RESULTS: The ratio of posterior element load to graft load with increasing disc space distraction significantly decreased from 1.06 +/- 0.65 (1.4 mm distraction) to 0.30 +/- .13 (4.6 mm distraction) (P < .03). The posterior element load decreased significantly after the same distraction, from 46.1 +/- 22.0 to 18.7 +/- 9.7 N/Nm (P < .05). CONCLUSIONS: In spondylotic specimens (4-5 mm disc heights) disc space distraction in excess of 3.0 mm from preoperative height caused a significant decrease in both the ratio of posterior element to graft loading and posterior element loads. These findings may help explain recent clinical reports of a limit of effective disc space distraction.

Thoracic discography in healthy individuals. A controlled prospective study of magnetic resonance imaging and discography in asymptomatic and symptomatic individuals.

STUDY DESIGN: A prospective case-control investigation. OBJECTIVES: To determine the responses to thoracic discography of asymptomatic individuals. SUMMARY OF BACKGROUND DATA: Literature regarding lumbar and cervical discography reveals that even morphologically abnormal discs often are not painful, whereas painful discs typically exhibit anular or endplate disruption. METHODS: Ten adult lifelong asymptomatic volunteers, ages 23 to 45 years, underwent magnetic resonance imaging of the thoracic spine, followed by four-level discography. Provocative responses were graded on a scale of 0 (no sensation) to 10 (extreme pain or pressure), and filmed discs were graded using a modified Dallas scheme. Concomitantly, 10 nonlitigious adults (6 men and 4 women, ages 31 to 55 years) experiencing chronic thoracic pain were similarly studied as a control group. RESULTS: The mean pain response in the asymptomatic volunteers was 2.4/10. Three discs were intensely painful (scores of 7/10, 8/10, 10/10), with all three exhibiting prominent endplate irregularities and anular tears typical of thoracolumbar Scheuermann's disease. On discography, 27 of 40 discs were abnormal, with endplate irregularities, anular tears, and/or herniations. Ten discs read as normal on magnetic resonance imaging showed anular pathology on discography. In the group with chronic thoracic pain, the average pain response was 6.3/10 (P < 0.05). Of the 48 discs studied, 24 were concordantly painful, with a pain response of 8.5/10 (P < 0.05); 17 had nonconcordant pain/pressure, with an average pain of 4.8/10 (P < 0.05); and 5 had no response. On magnetic resonance imaging 21 of the 48 discs appeared normal. However, on discography, only 10 were judged as normal. CONCLUSIONS: On discography, thoracic discs with prominent Schmorl's nodes may be intensely painful, even in lifelong asymptomatic individuals, but the pain is unfamiliar or nonconcordant. Thoracic discography may-demonstrate disc pathology not seen on magnetic resonance imaging.

Lumbar fusion results related to diagnosis.

STUDY DESIGN: Pain outcome and functional outcome after primary lumbar fusion surgery were determined by a self-assessment questionnaire. The responses were correlated with various clinical parameters. OBJECTIVES: To determine the result of fusion surgery among patients in various diagnostic groups using semiquantitative outcome scales. SUMMARY OF BACKGROUND DATA: Most previous studies on the results of primary lumbar fusion have reported the presence of pain, but few have addressed function outcomes. Results of a literature review were inconclusive as to whether a patient's diagnosis is a predictor of improved results. METHODS: During the 3-year period from 1988 to 1990, 165 patients underwent a primary lumbar fusion procedure. They had a chart and radiograph review and were categorized into five major diagnostic groups: 1) pediatric, 2) grade I-II spondylolisthesis (low-slip), 3) grade III-IV spondylolisthesis (high-slip), 4) degenerative disc disease, and 5) postdiscectomy. At a follow-up period of 5 years (mean) after the fusion, patients were mailed a questionnaire in which they described their pain and functional status before and after their lumbar fusion surgery. Questionnaires were returned by 92% of the patients. The questionnaire scores, complications, and revision procedures were grouped by patient diagnosis and analyzed. RESULTS: Patient satisfaction with the results of primary lumbar fusion ranged from 69% (for the postdiscectomy group) to 100% (for the pediatric and high-slip groups). For all diagnostic groups, lumbar fusion resulted in a significant decrease in back pain and leg pain (visual analog scale), which was maintained throughout the follow-up period. For back pain, the pediatric and high-slip groups showed significantly more improvement than the degenerative disc disease or postdiscectomy groups. Leg pain among patients in the pediatric and high-slip groups was significantly more improved than leg pain among patients in the low-slip, degenerative disc disease, or postdiscectomy groups. There was no deterioration of pain scores during the follow-up period. After fusion, all groups had a significant decrease in Oswestry disability scores; patients in the pediatric and high-slip group had significantly more improvement than patients in the degenerative disc disease or postdiscectomy groups. High- and low-slip groups had a significant improvement in their pain drawing score. Medication use was substantially reduced in all groups. After fusion, a lack of improvement in back pain score or disability score was significantly correlated with pseudarthrosis. CONCLUSIONS: The outcome of primary lumbar fusion surgery was decreased pain and increased function for the majority of patients in all five diagnostic categories. The amount of improvement varied by diagnostic group. Patients with developmental conditions showed greater improvement than patients with degenerative conditions.

The natural history of asymptomatic thoracic disc herniations.

STUDY DESIGN: Magnetic resonance imaging was used to determine the natural history of asymptomatic thoracic disc herniations. OBJECTIVES: To determine whether thoracic disc herniations change in size over time. SUMMARY OF BACKGROUND DATA: Based on previous work by the authors of the present study, the incidence of asymptomatic thoracic disc herniations is approximately 37%. The natural history of thoracic disc herniations is unknown. The natural history of lumbar and cervical disc herniations in symptomatic individuals who become asymptomatic has been shown in multiple studies frequently to result in a decrease in size of the herniation. METHODS: Twenty patients with 48 asymptomatic thoracic herniations previously diagnosed with magnetic resonance imaging underwent repeat magnetic resonance imaging using sagittal T1-weighted spine echo and axial multiplanar gradient refocused images at each thoracic disc level from T1 to T12 for a mean follow-up period of 26 months. Midsagittal canal diameter was recorded, and disc herniation square area was measured using a computer-assisted digitizing program. Disc herniations were categorized according to percentage of canal compromise. The change in size of the disc herniations over time was analyzed. RESULTS: All patients remained asymptomatic during the follow-up period. A total of 48 disc herniations were identified from the original magnetic resonance images. There were 21 small (0-10% canal compromise) disc herniations, 20 medium (> 10-20%) disc herniations, and seven large (> 20%) disc herniations. Of the 21 small disc herniations, 18 showed no significant change in size, whereas three showed a measurable increase in size. Of the 20 medium-sized disc herniations, 16 showed either a small or no change in size, one showed a significant increase in size, and three showed a significant decrease in size. Of the seven large disc herniations, three demonstrated no change in size, and four demonstrated a significant decrease in size. In addition, five new disc herniations were detected in four patients; one was small, and four were moderate in size. CONCLUSIONS: Based on the results of this study, the authors believe that asymptomatic disc herniations may well exist in a state of relative flux, yet exhibit little change in size and remain asymptomatic. There was a trend, however, for small disc herniations either to remain unchanged or increase in size and for large disc herniations often to decrease in size.

Diagnosis and treatment of cervical radiculopathy and myelopathy.

Cervical spine disorders frequently require evaluation by an orthopaedic surgeon. With sufficient understanding of the pathophysiology, natural history, differential diagnosis, presenting signs and symptoms, and roentgenographic appearance, as well as the nonoperative and operative treatment options of radiculopathy and myelopathy, the treating surgeon can guide the majority of patients to an early return to functional activities. This paper briefly reviews the aforementioned requisites for successful management of cervical degenerative disorders.

Nonoperative treatments for sciatica: a pilot study for a randomized clinical trial.

OBJECTIVES: To assess the feasibility of patient recruitment, the ability of patients and clinicians to comply with study protocols, and the use of data collection instruments to collect cost-effectiveness data, and to obtain variability estimates for sample-size calculations for a full-scale trial. STUDY DESIGN: Prospective, observer-blinded, pilot randomized clinical trial. SETTING: Primary contact chiropractic and medical clinics. PATIENTS: Ages 20 to 65 years, with low back-related radiating leg pain (sciatica). OUTCOME MEASURES: Self-report questionnaires were administered at baseline and 3 and 12 weeks after randomization. The measures included leg and back pain severity, frequency and bothersomeness of symptoms, leg/back disability, medication use, global improvement, satisfaction, and health care utilization. INTERVENTIONS: Medical care, chiropractic care, and epidural steroid injections. RESULTS: A total of 706 persons were screened by phone to determine initial eligibility. Of these, over 90% of those persons contacted did not meet the entrance criteria. The most common reason for disqualification was that the duration of the complaint was longer than 3 months. Twenty patients were randomized into the study. All 3 groups showed substantial improvements in the main patient-rated outcomes at the end of the 12-week intervention phase. For leg pain, back pain, frequency and bothersomeness of leg symptoms, and Roland-Morris disability score, the percent improvement varied from 50% to 84%, and the corresponding effect sizes ranged from 0.8 to 2.2. Bothersomeness of leg symptoms was the most responsive outcome associated with the largest magnitude of effect size. All within-group changes from baseline were statistically significant (P <.01). No between-group comparisons were planned or performed because of the insufficient sample size and high risk of committing type I and type II errors. CONCLUSIONS: Pilot studies such as these are important for the determination of the feasibility of conducting costly, larger scale trials. Recruitment for a full-scale study of sciatica of 2 to 12 weeks duration is not feasible, given the methods used in this pilot study. Our results do indicate, however, that there are substantial numbers of patients with sciatica more chronic in nature who would be interested in participating in a similar study. In addition, collaboration with a local health maintenance organization would likely facilitate clinician referrals and optimize the recruitment process. Patient and provider compliance was high in the pilot study, which indicates that most study protocols are feasible. Additionally, we were able to collect complete outcomes data, including those regarding health care use. A suggested modification by investigators and outside consultants has resulted in the replacement of the medication group with a minimal intervention control group (ie, self-care advice). As a result, a second pilot study of patients with sciatica of more than 4 weeks duration has been planned before a full-scale trial is attempted.