Búsqueda | Biblioteca Virtual en Salud Fronteriza

1.

A new type of blood-brain barrier aminoacidopathy underlies metabolic microcephaly associated with SLC1A4 mutations.

Odeh, Maali; Sajrawi, Clara; Majcher, Adam; Zubedat, Salman; Shaulov, Lihi; Radzishevsky, Alex; Mizrahi, Liron; Chung, Wendy K; Avital, Avi; Hornemann, Thorsten; Liebl, Daniel J; Radzishevsky, Inna; Wolosker, Herman.

Brain ; 2024 Apr 25.

Artículo en Inglés | MEDLINE | ID: mdl-38662784

2.

Recurrent de-novo gain-of-function mutation in SPTLC2 confirms dysregulated sphingolipid production to cause juvenile amyotrophic lateral sclerosis.

Dohrn, Maike F; Beijer, Danique; Lone, Museer A; Bayraktar, Elif; Oflazer, Piraye; Orbach, Rotem; Donkervoort, Sandra; Foley, A Reghan; Rose, Aubrey; Lyons, Michael; Louie, Raymond J; Gable, Kenneth; Dunn, Teresa; Chen, Sitong; Danzi, Matt C; Synofzik, Matthis; Bönnemann, Carsten G; Nazli Basak, A; Hornemann, Thorsten; Zuchner, Stephan.

J Neurol Neurosurg Psychiatry ; 95(3): 201-205, 2024 Feb 14.

Artículo en Inglés | MEDLINE | ID: mdl-38041684

3.

Recurrent de novo SPTLC2 variant causes childhood-onset amyotrophic lateral sclerosis (ALS) by excess sphingolipid synthesis.

Syeda, Safoora B; Lone, Museer A; Mohassel, Payam; Donkervoort, Sandra; Munot, Pinki; França, Marcondes C; Galarza-Brito, Juan Eli; Eckenweiler, Matthias; Asamoah, Alexander; Gable, Kenneth; Majumdar, Anirban; Schumann, Anke; Gupta, Sita D; Lakhotia, Arpita; Shieh, Perry B; Foley, A Reghan; Jackson, Kelly E; Chao, Katherine R; Winder, Thomas L; Catapano, Francesco; Feng, Lucy; Kirschner, Janbernd; Muntoni, Francesco; Dunn, Teresa M; Hornemann, Thorsten; Bönnemann, Carsten G.

J Neurol Neurosurg Psychiatry ; 95(2): 103-113, 2024 Jan 11.

Artículo en Inglés | MEDLINE | ID: mdl-38041679

4.

Serine deficiency causes complications in diabetes.

Hornemann, Thorsten.

Nature ; 614(7946): 42-43, 2023 02.

Artículo en Inglés | MEDLINE | ID: mdl-36697725

5.

The atypical sphingolipid SPB 18:1(14Z);O2 is a biomarker for DEGS1 related hypomyelinating leukodystrophy.

Hülsmeier, Andreas J; Toelle, Sandra P; Bellstedt, Peter; Wentzel, Christian; Bahr, Angela; Kolokotronis, Konstantinos; Hornemann, Thorsten.

J Lipid Res ; 64(12): 100464, 2023 12.

Artículo en Inglés | MEDLINE | ID: mdl-37890668

6.

Normalization of lipid oxidation defects arising from hypoxia early posthepatectomy prevents liver failure in mouse.

Birrer, Dominique Lisa; Kachaylo, Ekaterina; Breuer, Eva; Linecker, Michael; Kron, Philipp; Ungethüm, Udo; Hagedorn, Catherine; Steiner, Regula; Kälin, Carola; Borrego, Lucia Bautista; Dufour, Jean-Francois; Foti, Michelangelo; Hornemann, Thorsten; Clavien, Pierre-Alain; Humar, Bostjan.

Am J Transplant ; 23(2): 190-201, 2023 02.

Artículo en Inglés | MEDLINE | ID: mdl-36804129

7.

Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy.

Costantino, Sarah; Mengozzi, Alessandro; Velagapudi, Srividya; Mohammed, Shafeeq Ahmed; Gorica, Era; Akhmedov, Alexander; Mongelli, Alessia; Pugliese, Nicola Riccardo; Masi, Stefano; Virdis, Agostino; Hülsmeier, Andreas; Matter, Christian Matthias; Hornemann, Thorsten; Melina, Giovanni; Ruschitzka, Frank; Luscher, Thomas Felix; Paneni, Francesco.

Cardiovasc Diabetol ; 22(1): 312, 2023 11 13.

Artículo en Inglés | MEDLINE | ID: mdl-37957697

8.

Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases.

Lone, Museer A; Hülsmeier, Andreas J; Saied, Essa M; Karsai, Gergely; Arenz, Christoph; von Eckardstein, Arnold; Hornemann, Thorsten.

Proc Natl Acad Sci U S A ; 117(27): 15591-15598, 2020 07 07.

Artículo en Inglés | MEDLINE | ID: mdl-32576697

9.

Plasma Sphingoid Base Profiles of Patients Diagnosed with Intrinsic or Idiosyncratic Drug-induced Liver Injury.

Gai, Zhibo; Samodelov, Sophia L; Alecu, Irina; Hornemann, Thorsten; Grove, Jane I; Aithal, Guruprasad P; Visentin, Michele; Kullak-Ublick, Gerd A.

Int J Mol Sci ; 24(3)2023 Feb 03.

Artículo en Inglés | MEDLINE | ID: mdl-36769329

10.

Precision mouse models of Yars/dominant intermediate Charcot-Marie-Tooth disease type C and Sptlc1/hereditary sensory and autonomic neuropathy type 1.

Hines, Timothy J; Tadenev, Abigail L D; Lone, Museer A; Hatton, Courtney L; Bagasrawala, Inseyah; Stum, Morgane G; Miers, Kathy E; Hornemann, Thorsten; Burgess, Robert W.

J Anat ; 241(5): 1169-1185, 2022 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-34875719

11.

Lipidomics in Biomarker Research.

Hornemann, Thorsten.

Handb Exp Pharmacol ; 270: 493-510, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-34409495

12.

Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases.

Lone, Museer A; Bourquin, Florence; Hornemann, Thorsten.

Adv Exp Med Biol ; 1372: 47-56, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-35503173

13.

Discovery and Mechanism of Action of Small Molecule Inhibitors of Ceramidases.

Healey, Robert D; Saied, Essa M; Cong, Xiaojing; Karsai, Gergely; Gabellier, Ludovic; Saint-Paul, Julie; Del Nero, Elise; Jeannot, Sylvain; Drapeau, Marion; Fontanel, Simon; Maurel, Damien; Basu, Shibom; Leyrat, Cedric; Golebiowski, Jérôme; Bossis, Guillaume; Bechara, Cherine; Hornemann, Thorsten; Arenz, Christoph; Granier, Sebastien.

Angew Chem Int Ed Engl ; 61(2): e202109967, 2022 01 10.

Artículo en Inglés | MEDLINE | ID: mdl-34668624

14.

Metabolism of HSAN1- and T2DM-associated 1-deoxy-sphingolipids inhibits the migration of fibroblasts.

Karsai, Gergely; Steiner, Regula; Kaech, Andres; Lone, Museer A; von Eckardstein, Arnold; Hornemann, Thorsten.

J Lipid Res ; 62: 100122, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-34563520

15.

FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome.

Karsai, Gergely; Lone, Museer; Kutalik, Zoltán; Brenna, J Thomas; Li, Hongde; Pan, Duojia; von Eckardstein, Arnold; Hornemann, Thorsten.

J Biol Chem ; 295(7): 1889-1897, 2020 02 14.

Artículo en Inglés | MEDLINE | ID: mdl-31862735

16.

Macrophage NCOR1 protects from atherosclerosis by repressing a pro-atherogenic PPARÎ³ signature.

Oppi, Sara; Nusser-Stein, Stefanie; Blyszczuk, Przemyslaw; Wang, Xu; Jomard, Anne; Marzolla, Vincenzo; Yang, Kangmin; Velagapudi, Srividya; Ward, Liam J; Yuan, Xi-Ming; Geiger, Martin A; Guillaumon, Ana T; Othman, Alaa; Hornemann, Thorsten; Rancic, Zoran; Ryu, Dongryeol; Oosterveer, Maaike H; Osto, Elena; Lüscher, Thomas F; Stein, Sokrates.

Eur Heart J ; 41(9): 995-1005, 2020 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-31529020

17.

Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice.

Chen, Rong; Hornemann, Thorsten; Stefanic, Sasa; Schraner, Elisabeth M; Zuellig, Richard; Reding, Theresia; Malagola, Ermanno; Henstridge, Darren C; Hills, Andrew P; Graf, Rolf; Sonda, Sabrina.

Diabetologia ; 63(9): 1885-1899, 2020 09.

Artículo en Inglés | MEDLINE | ID: mdl-32385601

18.

Simple Targeted Assays for Metabolic Pathways and Signaling: A Powerful Tool for Targeted Proteomics.

Kopczynski, Dominik; Hentschel, Andreas; Coman, Cristina; Schebb, Nils Helge; Hornemann, Thorsten; Mashek, Douglas G; Hartung, Nicole M; Shevchuk, Olga; Schött, Hans-Frieder; Lorenz, Kristina; Torta, Federico; Burla, Bo; Zahedi, René P; Sickmann, Albert; Kreutz, Michael R; Ejsing, Christer S; Medenbach, Jan; Ahrends, Robert.

Anal Chem ; 92(20): 13672-13676, 2020 10 20.

Artículo en Inglés | MEDLINE | ID: mdl-32865986

19.

Farnesoid X receptor activation induces the degradation of hepatotoxic 1-deoxysphingolipids in non-alcoholic fatty liver disease.

Gai, Zhibo; Gui, Ting; Alecu, Irina; Lone, Museer A; Hornemann, Thorsten; Chen, Qingfa; Visentin, Michele; Hiller, Christian; Hausler, Stephanie; Kullak-Ublick, Gerd A.

Liver Int ; 40(4): 844-859, 2020 04.

Artículo en Inglés | MEDLINE | ID: mdl-31883408

20.

Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy.

Costantino, Sarah; Akhmedov, Alexander; Melina, Giovanni; Mohammed, Shafeeq A; Othman, Alaa; Ambrosini, Samuele; Wijnen, Winandus J; Sada, Lidia; Ciavarella, Giuseppino M; Liberale, Luca; Tanner, Felix C; Matter, Christian M; Hornemann, Thorsten; Volpe, Massimo; Mechta-Grigoriou, Fatima; Camici, Giovanni G; Sinatra, Riccardo; Lüscher, Thomas F; Paneni, Francesco.

Eur Heart J ; 40(12): 997-1008, 2019 03 21.

Artículo en Inglés | MEDLINE | ID: mdl-30629164

Biblioteca Virtual en Salud Fronteriza

México - Estados Unidos

Su selección (0)

Formato de exportación:

Exportar: