Nodeless electron pairing in CsV3Sb5-derived kagome superconductors.

The newly discovered kagome superconductors represent a promising platform for investigating the interplay between band topology, electronic order and lattice geometry1-9. Despite extensive research efforts on this system, the nature of the superconducting ground state remains elusive10-17. In particular, consensus on the electron pairing symmetry has not been achieved so far18-20, in part owing to the lack of a momentum-resolved measurement of the superconducting gap structure. Here we report the direct observation of a nodeless, nearly isotropic and orbital-independent superconducting gap in the momentum space of two exemplary CsV3Sb5-derived kagome superconductors-Cs(V0.93Nb0.07)3Sb5 and Cs(V0.86Ta0.14)3Sb5-using ultrahigh-resolution and low-temperature angle-resolved photoemission spectroscopy. Remarkably, such a gap structure is robust to the appearance or absence of charge order in the normal state, tuned by isovalent Nb/Ta substitutions of V. Our comprehensive characterizations of the superconducting gap provide indispensable information on the electron pairing symmetry of kagome superconductors, and advance our understanding of the superconductivity and intertwined electronic orders in quantum materials.

Scaling of the strange-metal scattering in unconventional superconductors.

Marked evolution of properties with minute changes in the doping level is a hallmark of the complex chemistry that governs copper oxide superconductivity as manifested in the celebrated superconducting domes and quantum criticality taking place at precise compositions1-4. The strange-metal state, in which the resistivity varies linearly with temperature, has emerged as a central feature in the normal state of copper oxide superconductors5-9. The ubiquity of this behaviour signals an intimate link between the scattering mechanism and superconductivity10-12. However, a clear quantitative picture of the correlation has been lacking. Here we report the observation of precise quantitative scaling laws among the superconducting transition temperature (Tc), the linear-in-T scattering coefficient (A1) and the doping level (x) in electron-doped copper oxide La2-xCexCuO4 (LCCO). High-resolution characterization of epitaxial composition-spread films, which encompass the entire overdoped range of LCCO, has enabled us to systematically map its structural and transport properties with unprecedented accuracy and with increments of Δx = 0.0015. We have uncovered the relations Tc ~ (xc - x)0.5 ~ (A1□)0.5, where xc is the critical doping in which superconductivity disappears and A1□ is the coefficient of the linear resistivity per CuO2 plane. The striking similarity of the Tc versus A1□ relation among copper oxides, iron-based and organic superconductors may be an indication of a common mechanism of the strange-metal behaviour and unconventional superconductivity in these systems.

Origin of Interfacial Orbital Reconstruction in Perovskite Superlattices.

The competition between on-site electronic correlation and local crystal field stands out as a captivating topic in research. However, its physical ramifications often get overshadowed by influences of strong periodic potential and orbital hybridization. The present study reveals this competition may become more pronounced or even dominant in two-dimensional systems, driven by the combined effects of dimensional confinement and orbital anisotropy. This leads to electronic orbital reconstruction in certain perovskite superlattices or thin films. To explore the emerging physics, we investigate the interfacial orbital disorder-order transition with an effective Hamiltonian and how to modulate this transition through strains.

Optimal Robust Control of Nonlinear Systems with Unknown Dynamics via NN Learning with Relaxed Excitation.

This paper presents an adaptive learning structure based on neural networks (NNs) to solve the optimal robust control problem for nonlinear continuous-time systems with unknown dynamics and disturbances. First, a system identifier is introduced to approximate the unknown system matrices and disturbances with the help of NNs and parameter estimation techniques. To obtain the optimal solution of the optimal robust control problem, a critic learning control structure is proposed to compute the approximate controller. Unlike existing identifier-critic NNs learning control methods, novel adaptive tuning laws based on Kreisselmeier's regressor extension and mixing technique are designed to estimate the unknown parameters of the two NNs under relaxed persistence of excitation conditions. Furthermore, theoretical analysis is also given to prove the significant relaxation of the proposed convergence conditions. Finally, effectiveness of the proposed learning approach is demonstrated via a simulation study.

ANi5Bi5.6+δ (A = K, Rb, and Cs): Quasi-One-Dimensional Metals Featuring [Ni5Bi5.6+δ]- Double-Walled Column with Strong Diamagnetism.

A new series of compounds, ANi5Bi5.6+δ (where A = K, Rb, and Cs) are discovered with a quasi-one-dimensional (Q1D) [Ni5Bi5.6+δ]- double-walled column and a coaxial inner one-dimensional Bi atomic chain. The columns are linked to each other by intercolumn Bi-Bi bonds and separated by an A+ cation. Typical metallic behaviors with strong correlation of itinerant electrons and the Sommerfeld coefficient enhanced with the increasing cationic radius were experimentally observed and supported by first-principles calculations. Compared to AMn6Bi5 (where A = K, Rb, and Cs), the enhanced intercolumn distances and the substitution of Ni for Mn give rise to strong diamagnetic susceptibilities in ANi5Bi5.6+δ. First-principles calculations reveal possible uncharged Ni atoms with even number of electrons in ANi5Bi5.6+δ, which may explain the emergence of diamagnetism. ANi5Bi5.6+δ, as Q1D diamagnetic metals with strong electron correlation, provide a unique platform to understand exotic magnetism and explore novel quantum effects.

Adaptive Output Containment Tracking Control for Heterogeneous Wide-Area Networks with Aperiodic Intermittent Communication and Uncertain Leaders.

This paper proposes an adaptive distributed hybrid control approach to investigate the output containment tracking problem of heterogeneous wide-area networks with intermittent communication. First, a clustered network is modeled for a wide-area scenario. An aperiodic intermittent communication mechanism is exerted on the clusters such that clusters only communicate through leaders. Second, in order to remove the assumption that each follower must know the system matrix of the leaders and achieve output containment, a distributed adaptive hybrid control strategy is proposed for each agent under the internal model and adaptive estimation mechanism. Third, sufficient conditions based on average dwell-time are provided for the output containment achievement using a Lyapunov function method, from which the exponential stability of the closed-loop system is analyzed. Finally, simulation results are presented to demonstrate the effectiveness of the proposed adaptive distributed intermittent control strategy.

Hydrogen sulfide ameliorates abdominal aorta coarctation-induced myocardial fibrosis by inhibiting pyroptosis through regulating eukaryotic translation initiation factor 2α phosphorylation and activating PI3K/AKT1 pathway.

This study aimed to assess the effects of exogenous hydrogen sulfide (H2S) on abdominal aorta coarctation (AAC) induced myocardial fibrosis (MF) and autophagy in rats. Forty-four Sprague-Dawley rats were randomly divided into control group, AAC group, AAC + H2S group, and H2S control group. After a model of rats with AAC was built surgically, AAC + H2S group and H2S group were injected intraperitoneally with H2S (100 µmol/kg) daily. The rats in the control group and the AAC group were injected with the same amount of PBS. We observed that H2S can improve left ventricular function and the deposition of myocardial collagen fibers, inhibit pyroptosis, down-regulate the expression of P-eif2α in myocardial tissue, and inhibit cell autophagy by activating the phosphatidylinositol 3-kinase (PI3K)/AKT1 signaling pathway (p < 0.05). In addition, angiotensin II (1 µM) H9c2 cardiomyocytes were injured in vitro experiments, and it was also observed that pyroptosis was inhibited after H2S (400 µmol/kg) intervention, the expression of P-eif2α in cardiomyocytes was significantly down-regulated, and the PI3K/AKT1 signaling pathway was activated at the same time. Therefore, increasing the expression of P-eif2α reverses the activation of the PI3K/AKT1 signaling pathway by H2S. In conclusion, these findings suggest that exogenous H2S can ameliorate MF in rats with AAC by inhibiting pyroptosis, and the mechanism may be associated with inhibiting the phosphorylation of eif2α and activating the PI3K/AKT1 signaling pathway to inhibit excessive cell autophagy.

Trimming Crystallizable Fragment (Fc) Glycans Enables the Direct Enzymatic Transfer of Biomacromolecules to Antibodies as Therapeutics.

Glycoengineering has provided powerful tools to construct site-specific antibody conjugates. However, only small-molecule payloads can be directly transferred to native or engineered antibodies using existing glycoengineering strategies. Herein, we demonstrate that reducing the complexity of crystallizable fragment (Fc) glycans could dramatically boost the chemoenzymatic modification of immunoglobulin G (IgG) via an engineered fucosyltransferase. In this platform, antibodies with Fc glycans engineered to a simple N-acetyllactosamine (LacNAc) disaccharide are successfully conjugated to biomacromolecules, such as oligonucleotides and nanobodies, in a single step within hours. Accordingly, we synthesized an antibody-conjugate-based anti-human epidermal growth factor receptor 2 (HER2)/ cluster of differentiation 3 (CD3) bispecific antibody and used it to selectively destroy patient-derived cancer organoids by reactivating endogenous T lymphocyte cells (T cells) inside the organoid. Our results highlight that this platform is a general approach to construct antibody-biomacromolecule conjugates with translational values.

Novel melatonin-trientine conjugate as potential therapeutic agents for Alzheimer's disease.

Researchers continue to explore drug targets to treat the characteristic pathologies of Alzheimer's disease (AD). Some drugs relieve the pathological processes of AD to some extent, but the failed clinical trials indicate that multifunctional agents seem more likely to achieve the therapy goals for this neurodegenerative disease. Herein, a novel compound named melatonin-trientine (TM) has been covalently synthesized with the natural antioxidant compounds melatonin and the metal ion chelator trientine. After toxicological and pharmacokinetic verification, we elucidated the effects of intraperitoneal administration of TM on AD-like pathology in 6-month-old mice that express both the ß-amyloid (Aß) precursor protein and presenilin-1 (APP/PS1). We found that TM significantly decreased Aß deposition and neuronal degeneration in the brains of the APP/PS1 double transgenic mice. This result may be due to the upregulation of iron regulatory protein-2 (IRP2), insulin degrading enzyme (IDE), and low density lipoprotein receptor related protein 1 (LRP1), which leads to decreases in APP and Aß levels. Additionally, TM may promote APP non-amyloidogenic processing by activating the melatonin receptor-2 (MT2)-dependent signaling pathways, but not MT1. In addition, TM plays an important role in blocking γ-secretase, tau hyperphosphorylation, neuroinflammation, oxidative stress, and metal ion dyshomeostasis. Our results suggest that TM may effectively maximize the therapeutic efficacy of targeting multiple mechanisms associated with AD pathology.

Fermion Doubling Theorems in Two-Dimensional Non-Hermitian Systems for Fermi Points and Exceptional Points.

The fermion doubling theorem plays a pivotal role in Hermitian topological materials. It states, for example, that Weyl points must come in pairs in three-dimensional semimetals. Here, we present an extension of the doubling theorem to non-Hermitian lattice Hamiltonians. We focus on two-dimensional non-Hermitian systems without any symmetry constraints, which can host two different types of topological point nodes, namely, (i) Fermi points and (ii) exceptional points. We show that these two types of protected point nodes obey doubling theorems, which require that the point nodes come in pairs. To prove the doubling theorem for exceptional points, we introduce a generalized winding number invariant, which we call the "discriminant number." Importantly, this invariant is applicable to any two-dimensional non-Hermitian Hamiltonian with exceptional points of arbitrary order and, moreover, can also be used to characterize nondefective degeneracy points. Furthermore, we show that a surface of a three-dimensional system can violate the non-Hermitian doubling theorems, which implies unusual bulk physics.

Dissipative Floquet Majorana Modes in Proximity-Induced Topological Superconductors.

We study a realistic Floquet topological superconductor, a periodically driven nanowire proximitized to an equilibrium s-wave superconductor. Because of the strong energy and density fluctuations caused by the superconducting proximity effect, the Floquet Majorana wire becomes dissipative. We show that the Floquet band structure is still preserved in this dissipative system. In particular, we find that the Floquet Majorana zero and π modes can no longer be simply described by the Floquet topological band theory. We also propose an effective model to simplify the calculation of the lifetime of these Floquet Majoranas and find that the lifetime can be engineered by the external driving field.

Dirac semimetal in ß-CuI without surface Fermi arcs.

Anomalous surface states with Fermi arcs are commonly considered to be a fingerprint of Dirac semimetals (DSMs). In contrast to Weyl semimetals, however, Fermi arcs of DSMs are not topologically protected. Using first-principles calculations, we predict that ß-cuprous iodide (ß-CuI) is a peculiar DSM whose surface states form closed Fermi pockets instead of Fermi arcs. In such a fermiological Dirac semimetal, the deformation mechanism from Fermi arcs to Fermi pockets stems from a large cubic term preserving all crystal symmetries and from the small energy difference between the surface and bulk Dirac points. The cubic term in ß-CuI, usually negligible in prototypical DSMs, becomes relevant because of the particular crystal structure. As such, we establish a concrete material example manifesting the lack of topological protection for surface Fermi arcs in DSMs.

Non-Hermitian Bulk-Boundary Correspondence and Auxiliary Generalized Brillouin Zone Theory.

We provide a systematic and self-consistent method to calculate the generalized Brillouin zone (GBZ) analytically in one-dimensional non-Hermitian systems, which helps us to understand the non-Hermitian bulk-boundary correspondence. In general, a n-band non-Hermitian Hamiltonian is constituted by n distinct sub-GBZs, each of which is a piecewise analytic closed loop. Based on the concept of resultant, we can show that all the analytic properties of the GBZ can be characterized by an algebraic equation, the solution of which in the complex plane is dubbed as auxiliary GBZ (aGBZ). We also provide a systematic method to obtain the GBZ from aGBZ. Two physical applications are also discussed. Our method provides an analytic approach to the spectral problem of open boundary non-Hermitian systems in the thermodynamic limit.

Jones Polynomial and Knot Transitions in Hermitian and non-Hermitian Topological Semimetals.

Topological nodal line semimetals host stable chained, linked, or knotted line degeneracies in momentum space protected by symmetries. In this Letter, we use the Jones polynomial as a general topological invariant to capture the global knot topology of the oriented nodal lines. We show that every possible change in Jones polynomial is attributed to the local evolutions around every point where two nodal lines touch. As an application of our theory, we show that nodal chain semimetals with four touching points can evolve to a Hopf link. We extend our theory to 3D non-Hermitian multiband exceptional line semimetals. Our work provides a recipe to understand the transition of the knot topology for protected nodal lines.

Neutron Spin Resonance in a Quasi-Two-Dimensional Iron-Based Superconductor.

The neutron spin resonance is generally regarded as a key to understanding the magnetically mediated Cooper pairing in unconventional superconductors. Here, we report an inelastic neutron scattering study on the low-energy spin excitations in a quasi-two-dimensional iron-based superconductor KCa_{2}Fe_{4}As_{4}F_{2}. We have discovered a two-dimensional spin resonant mode with downward dispersions, a behavior closely resembling the low branch of the hourglass-type spin resonance in cuprates. While the resonant intensity is predominant by two broad incommensurate peaks near Q=(0.5,0.5) with a sharp energy peak at E_{R}=16 meV, the overall energy dispersion of the mode exceeds the measured maximum total gap Δ_{tot}=|Δ_{k}|+|Δ_{k+Q}|. These results deeply challenge the conventional understanding of the resonance modes as magnetic excitons regardless of underlining pairing symmetry schemes, and it also points out that when the iron-based superconductivity becomes very quasi-two-dimensional, the electronic behaviors are similar to those in cuprates.

Quasi-1D Topological Nodal Vortex Line Phase in Doped Superconducting 3D Dirac Semimetals.

We study vortex bound states in three-dimensional (3D) superconducting Dirac semimetals with time reversal symmetry. We find that there exist robust gapless vortex bound states propagating along the vortex line in the s-wave superconducting state. We refer to this newly found phase as the quasi-1D nodal vortex line phase. According to the Altland-Zirnbauer classification, the phase is characterized by a topological index (ν;N) at k_{z}=0 and k_{z}=π, where ν is the Z_{2} topological invariant for a 0D class-D system and N is the Z topological invariant for a 0D class-A system. Furthermore, we show that the vortex end Majorana zero mode can coexist with the quasi-1D nodal phase in certain types of Dirac semimetals. The possible experimental observations and material realization of such nodal vortex line states are discussed.

Nodeless High-T_{c} Superconductivity in the Highly Overdoped CuO_{2} Monolayer.

We study the electronic structure and superconductivity in a CuO_{2} monolayer grown recently on the d-wave cuprate superconductor Bi_{2}Sr_{2}CaCu_{2}O_{8+δ}. Density functional theory calculations indicate a significant charge transfer across the interface such that the CuO_{2} monolayer is heavily overdoped into the hole-rich regime yet inaccessible in bulk cuprates. We show that both the Cu d_{x^{2}-y^{2}} and d_{3z^{2}-r^{2}} orbitals become important and the Fermi surface contains one electron and one hole pocket associated with the two orbitals, respectively. Constructing a minimal correlated two-orbital model for the e_{g} complex, we show that the spin-orbital exchange interactions produce a nodeless superconductor with extended s-wave pairing symmetry and a pairing energy gap comparable to the bulk d-wave gap, in agreement with recent experiments. The findings point to a direction of realizing new high-T_{c} superconductors in ozone grown transition-metal-oxide monolayer heterostructures.

Odd and Even Modes of Neutron Spin Resonance in the Bilayer Iron-Based Superconductor CaKFe_{4}As_{4}.

We report an inelastic neutron scattering study on the spin resonance in the bilayer iron-based superconductor CaKFe_{4}As_{4}. In contrast to its quasi-two-dimensional electron structure, three strongly L-dependent modes of spin resonance are found below T_{c}=35 K. The mode energies are below and linearly scale with the total superconducting gaps summed on the nesting hole and electron pockets, essentially in agreement with the results in cuprate and heavy fermion superconductors. This observation supports the sign-reversed Cooper pairing mechanism under multiple pairing channels and resolves the long-standing puzzles concerning the broadening and dispersive spin resonance peak in iron pnictides. More importantly, the triple resonant modes can be classified into odd and even symmetries with respect to the distance of Fe-Fe planes within the Fe-As bilayer unit. Thus, our results closely resemble those in the bilayer cuprates with nondegenerate spin excitations, suggesting that these two high-T_{c} superconducting families share a common nature.

Safety and efficacy of enhanced recovery after surgery (ERAS) programs in patients undergoing hepatectomy: A prospective randomized controlled trial.

BACKGROUND AND AIM: Enhanced recovery after surgery (ERAS) programs, following a variety of perioperative treatments with evidence-based medical evidence, has indicated its validity to accelerate rehabilitation in a wide variety of surgical procedures. This randomized controlled trial (RCT) study was implemented to verify the safety and efficacy of the perioperative effects in patients undergoing hepatectomy with ERAS or with conventional surgery (CS). METHODS: From August 2016 to November 2017, according to the inclusion criteria, 160 patients with liver diseases were suitable for participating in this experiment. Patients before liver resection were randomized into ERAS group (n = 80) and CS group (n = 80), and then the outcome measures were compared between the two groups. RESULTS: Enhanced recovery after surgery group had significantly less complications than CS group (P = .009). Compared with CS group, patients in ERAS group had low peak of WBCs in postoperative day (POD1), ALT in POD1 and POD3 (P < .05), high value of ALB in POD3 and POD5 (P < .05), less pain and higher patient satisfaction (P < .001), earlier exhaust, oral feeding, ambulation and extubation time (P < .05),and also had less hospital stay and cost (P < .001). There were no significant differences in readmission rate (<30 days) between two groups (P = .772). CONCLUSIONS: Enhanced recovery after surgery programs applied to patients undergoing hepatectomy can safely and effectively relieve stress response, reduce the incidence of complications, improve patient satisfaction, accelerate patient recovery, reduce financial burden, and bring economic benefits.

Dirac and Nodal Line Magnons in Three-Dimensional Antiferromagnets.

We study the topological properties of magnon excitations in three-dimensional antiferromagnets, where the ground state configuration is invariant under time reversal followed by space inversion (PT symmetry). We prove that Dirac points and nodal lines, the former being the limiting case of the latter, are the generic forms of symmetry-protected band crossings between magnon branches. As a concrete example, we study a Heisenberg spin model for a "spin-web" compound, Cu_{3}TeO_{6}, and show the presence of the magnon Dirac points assuming a collinear magnetic structure. Upon turning on symmetry-allowed Dzyaloshinsky-Moriya interactions, which introduce a small noncollinearity in the ground state configuration, we find that the Dirac points expand into nodal lines with nontrivial Z_{2}-topological charge, a new type of nodal line not predicted in any materials so far.