Forward-backward and period doubling bifurcations in a discrete epidemic model with vaccination and limited medical resources.

A discrete epidemic model with vaccination and limited medical resources is proposed to understand its underlying dynamics. The model induces a nonsmooth two dimensional map that exhibits a surprising array of dynamical behavior including the phenomena of the forward-backward bifurcation and period doubling route to chaos with feasible parameters in an invariant region. We demonstrate, among other things, that the model generates the above described phenomena as the transmission rate or the basic reproduction number of the disease gradually increases provided that the immunization rate is low, the vaccine failure rate is high and the medical resources are limited. Finally, the numerical simulations are provided to illustrate our main results.

Incorporating economic constraints for optimal control of immunizing infections.

It is well-known that the interruption of transmission of a disease can be achieved, provided the vaccinated population reaches a threshold depending on, among others, the efficacy of vaccines. The purpose of this paper is to address the optimal vaccination strategy by imposing the economic constraints. In particular, an S--(I,V)--S model used to describe the spreading of the disease in a well-mixed population and a cost function consisting of vaccination and infection costs are proposed. The well-definedness of the above-described modeling is provided. We were then able to provide an optimal strategy to minimize the cost for all parameters. In particular, the optimal vaccination level to minimize the cost can be completely characterized for all parameters. For instance, the optimal vaccination level can be classified by the magnitude of the failure rate of the vaccine with other parameters being given. Under these circumstances, the optimal strategy to minimize the cost is roughly to eliminate the disease locally (respectively, choose an economic optimum resulting in not to wipe out the disease completely or take no vaccination for anyone) provided the vaccine failure rate is relatively small (respectively, intermediate or large). Numerical simulations to illustrate our main results are also provided. Moreover, the data collected at the height of the Covid-19 pandemic in Taiwan are also numerically simulated to provide the corresponding optimal vaccination strategy.

Global stability for epidemic models on multiplex networks.

In this work, we consider an epidemic model in a two-layer network in which the dynamics of susceptible-infected-susceptible process in the physical layer coexists with that of a cyclic process of unaware-aware-unaware in the virtual layer. For such multiplex network, we shall define the basic reproduction number [Formula: see text] in the virtual layer, which is similar to the basic reproduction number [Formula: see text] defined in the physical layer. We show analytically that if [Formula: see text] and [Formula: see text], then the disease and information free equilibrium is globally stable and if [Formula: see text] and [Formula: see text], then the disease free and information saturated equilibrium is globally stable for all initial conditions except at the origin. In the case of [Formula: see text], whether the disease dies out or not depends on the competition between how well the information is transmitted in the virtual layer and how contagious the disease is in the physical layer. In particular, it is numerically demonstrated that if the difference in [Formula: see text] and [Formula: see text] is greater than the product of [Formula: see text], the deviation of [Formula: see text] from 1 and the relative infection rate for an aware susceptible individual, then the disease dies out. Otherwise, the disease breaks out.

Diversity of hysteresis in a fully cooperative coinfection model.

We propose a fully cooperative coinfection model in which singly infected individuals are more likely to acquire a second disease than susceptible ones and doubly infected individuals are also assumed to be more contagious than singly infected ones. The dynamics of such a fully cooperative coinfection model is investigated through the well-mixed approach. In particular, discontinuous outbreak transitions from the disease free state or the low prevalence state to the high prevalence state can be separately observed as a disease transmission rate crosses a threshold αo from the below when the epidemic is still in the early stages. Moreover, discontinuous eradications from the high prevalence state to the low prevalence or disease free state are also separately seen as the transmission rate reaches a threshold αe(<αo) from the above when the outbreak occurs. Such phenomena constitute three types of hysteresis, where only one type has been identified before. Complete characterization of these three types of hysteresis in terms of parameters measuring the uniformity of the model is both analytically and numerically provided.

Multistability of a Two-Dimensional Map Arising in an Influenza Model.

In this paper, we propose and analyze a nonsmoothly two-dimensional map arising in a seasonal influenza model. Such map consists of both linear and nonlinear dynamics depending on where the map acts on its domain. The map exhibits a complicated and unpredictable dynamics such as fixed points, period points, chaotic attractors, or multistability depending on the ranges of a certain parameters. Surprisingly, bistable states include not only the coexistence of a stable fixed point and stable period three points but also that of stable period three points and a chaotic attractor. Among other things, we are able to prove rigorously the coexistence of the stable equilibrium and stable period three points for a certain range of the parameters. Our results also indicate that heterogeneity of the population drives the complication and unpredictability of the dynamics. Specifically, the most complex dynamics occur when the underlying basic reproduction number with respect to our model is an intermediate value and the large portion of the population in the same compartment changes in states the following season.