RESUMEN
The MEGA-PRESS pulse sequence was used for determination of overlapping signals in the (1)H-MRS spectra of the human brain. For the first time, the balance of GABA glutamate/glutamine concentrations was estimated quantitatively in the human brain of patients with ultra-high risk of schizophrenia. It was found that GABA concentration and GABA/GLX ratios were significantly reduced in the left frontal lobe of UHR subjects.
Asunto(s)
Lóbulo Frontal/metabolismo , Ácido Glutámico/metabolismo , Glutamina/metabolismo , Espectroscopía de Protones por Resonancia Magnética/métodos , Esquizofrenia/metabolismo , Ácido gamma-Aminobutírico/metabolismo , Adolescente , Adulto , Creatina/metabolismo , Lóbulo Frontal/diagnóstico por imagen , Lateralidad Funcional , Humanos , Masculino , Síntomas Prodrómicos , Riesgo , Esquizofrenia/diagnóstico por imagen , Adulto JovenRESUMEN
Results of clinical and radiographic examinations of 43 patients, 4 to 15 years old, with pelvic polyfractures during acute- and long-term periods of trauma, and postmortem and experimental data were presented. A high rate of diagnostic mistakes and treatment failures in patients with pelvic polyfractures are defined. Depending on the location and pattern of pelvis injuries, the main reasons for complications are determined. A technique of external fixation with the application of a pivot device for managing pelvic polyfractures in children is described. The efficacy of the proposed curative tactics is shown by treatment results of 12 patients with pelvic polyfractures.
Asunto(s)
Fracturas Óseas/diagnóstico por imagen , Fracturas Óseas/terapia , Traumatismo Múltiple/terapia , Huesos Pélvicos/lesiones , Adolescente , Autopsia , Niño , Preescolar , Fijadores Externos , Femenino , Fracturas Óseas/patología , Humanos , Lactante , Masculino , Huesos Pélvicos/patología , RadiografíaRESUMEN
The results of organ-saving treatment for 84 children with closed transcapsular spleen rupture were studied. Criteria for the stipulation of differential curative tactics were present. Twenty-five children were treated conservatively. In 57 patients, different endosurgical manipulations were done. Laparotomy was done in 5 patients, including 3 patients who primarily had endosurgical treatment. Long-term results were studied for 29 children. The followup period was from 3 months to 4 years. Investigators showed that recommended tactics helped save organs in > 90% of children with transcapular splenic injuries. The possibility of restoring splenic structure and functional activity and preventing hyposplenism was proven by orthotopic saving of injured spleens.