Asunto(s)
Penicilinas/toxicidad , Contaminación Química del Agua/prevención & control , Agua/normas , Animales , Relación Dosis-Respuesta a Droga , Cobayas , Inmunidad Innata/efectos de los fármacos , Intestinos/efectos de los fármacos , Intestinos/microbiología , Dosificación Letal Mediana , Ratones , Ratas , Factores de Tiempo , U.R.S.S.RESUMEN
Immunological examination of women occupied in production of penicillin revealed a decrease in the phagocytic activity of the blood neutrophiles and the bactericidal properties of the skin, an increase in the quantitative composition of the autoflora of the skin and changes in its biochemical properties. Correlation between the changes in the values of the natural non-specific immunity as dependent on the level of the contact with the antibiotic was shown.
Asunto(s)
Industria Farmacéutica , Inmunidad/efectos de los fármacos , Penicilinas/farmacología , Adulto , Exposición a Riesgos Ambientales , Femenino , Humanos , Moscú , Neutrófilos/efectos de los fármacos , Fagocitosis/efectos de los fármacos , Piel/efectos de los fármacos , Piel/inmunología , Piel/microbiología , Factores de TiempoRESUMEN
Toxocity of ampicillin trihydrate was studied in acute and chronic experiments. It was shown that the antibiotic had low acute toxicity, did not cumulate and had no skin-irritating effect. On its inhalation in concentrations of 5 mg/m3 for 4 months, ampicillin induced allergization of albino rats, decreased their immunity. The general toxic effect of the drug was slightly pronounced. Ampicillin in a concentration of 0.1 mg/m3 induced tension of the immunological reactivity of the organism. The maximum permissible concentration (MPC) of ampicillin in the working premises equal to 0.1 mg/m3 is recommended. Mark "Allergen" is necessary.
Asunto(s)
Ampicilina/toxicidad , Animales , ADN/sangre , Relación Dosis-Respuesta a Droga , Hipersensibilidad a las Drogas/sangre , Exposición a Riesgos Ambientales , Eritrocitos/efectos de los fármacos , Cobayas , Antagonistas de los Receptores Histamínicos H1/sangre , Inmunidad/efectos de los fármacos , Dosificación Letal Mediana , Leucocitos/efectos de los fármacos , Concentración Máxima Admisible , Ratones , Neutrófilos/efectos de los fármacos , ARN/sangre , Conejos , Ratas , Piel/efectos de los fármacos , Pruebas Cutáneas , Factores de TiempoRESUMEN
A total of 90 persons being in contact with aminoglycosides and penicillin were examined. It was found that such a contact resulted in dysbacteriosis of the intestine. The culture of Coli bacteria isolated from the persons had a low fermentative activity and lost their mobility. Bificol, a biological preparation proved to be promising in the treatment of persons with dysfunction of the intestine against the background of dysbacteriosis.