[False positive result of 18F-FDG PET in patient with lung cancer due to sarcoid-like reaction in regional lymph nodes]. / Falszywie dodatni wynik badania 18F-FDG PET u pacjenta chorego na raka pluca spowodowany odczynem sarkoidalnym w regionalnych wezlach chlonnych.

The development of non-caseating granulomas in patients with neoplastic diseases is referred to as a sarcoid-like reaction. This reaction may be found in the primary tumour or near it; however, it is commonly seen in the regional lymph nodes, and usually subsides after treatment of the underlying disease. The pathogenesis of this process has not been fully explained. Sarcoid-like reactions occur in 4.4% of solid tumours, 7.3% of patients with non-Hodgkin's lymphoma, and 13.8% of patients with Hodgkin's lymphoma. The radiological image of increased lymph nodes due to the sarcoid-like reaction is similar to that of lymphadenopathy with neoplastic aetiology, and may create diagnostic difficulties. The paper presents the case of a patient with a sarcoid-like reaction in regional lymph nodes caused by lung cancer, and describes difficulties in the interpretation of results from positron emission tomography (18F-FDG PET), which may have led to inappropriate treatment. False-positive accumulation of radiotracer (fluorodeoxyglucose, FDG) in mediastinal and hilar lymph nodes in the patient, who had chemotherapy and right-side pneumonectomy, was unambiguously interpreted by the radiologists as the relapse of lung cancer. Considering the fact that the patient was in a very good condition and presented with no clinical symptoms that indicated the progression of cancer, we extended the medical diagnostics. The performed procedures ruled out neoplastic process and confirmed our assumptions regarding sarcoid-like reaction. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) was the diagnostic procedure that provided conclusive results. Sarcoid granulomas were identified by the pathomorphologist in the specimen. The patient avoided toxic treatment.

[Analysis of delivery types in women after previous cesarean section]. / Analiza sposobu zakonczenia ciazy u kobiet po przebytym cieciu cesarskim.

OBJECTIVE: The study was undertaken to analyze the course of pregnancy and delivery in women after previous cesarean section. MATERIAL AND METHODS: The study group consisted of 1272 pregnant women after one cesarean section, who delivered at the 1st Department of Gynecology and Obstetrics, Medical University of Lodz between 1st January 2007 and 31st December 2010. RESULTS: Among patients after previous cesarean section, the most numerous group constituted women whose pregnancy was resolved with an elective repeat cesarean section, without the attempt to deliver vaginally - 58,96% whereas the remaining 41,04% of the women were qualified to make an attempt at vaginal delivery 48,28% of them succeeded to gave birth vaginally and 51,72% underwent repeat cesarean section. CONCLUSIONS: Proper qualification of patients after previous caesarean section for a natural vaginal birth allows a successful vaginal delivery. A critical analysis of the indications for surgical delivery needs to be performed in order to lower the rate of cesarean sections.

[Intrauterine contraceptive device in an appendix--a case report]. / Wkladka wewnatrzmaciczna w wyrostku robaczkowym--opis przypadku.

The application of an intrauterine contraceptive device can perforate the uterus and migrate to adjacent organs such as the bladder or small bowel. The main symptoms are painful insertion of the intrauterine contraceptive device and missing IUD strings. The diagnosis of perforation and transuterine migration of the IUD is made on the basis of an ultrasound examination and an abdominal X-ray. The proper management is such case is immediate removal of the IUD. The aim of this paper was to present a case of a 34-year-old woman with a copper IUD found during a caesarean section.

[Pregnancy and delivery in a patient with non-Hodgkin lymphoma--a case report]. / CiAza i poród u pacjentki z chloniakiem nieziarniczym--opis przypadku.

INTRODUCTION: Neoplasmatic diseases during pregnancy are relatively rare, with the incidence of approximately 1/1000 pregnancies. The symptoms of neoplasmatic processes are unspecific and often mirror physiological changes during pregnancy Chemotherapy is the main therapeutic management of non-Hodgkin lymphomas. The strategy of the treatment and its influence on the course of pregnancy remain controversial. AIM: The aim of this study was to present the case of a pregnant woman with non-Hodgkin lymphoma. CASE REPORT: We described the case of a 27-year-old pregnant nullipara with anemia, breathlessness, cough and general weakness with diagnosed diffused large B-cell lymphoma. During pregnancy the patient received six cycles of CHOP chemotherapy without any serious complications. On 37 week of gestation the caesarean section was performed. CONCLUSIONS: Coexisting non-Hodgkin lymphomas and pregnancy are seldom the case and the treatment requires complex chemotherapy.

[Analysis of the indications for the caesarean section delivery for very low birthweight neonates (< 1500 g) delivered in I department gynecology and obstetrics, Medical University in Lodz in 2006-2010]. / Analiza wskazan do porodu droga ciecia cesarskiego noworodków ze skrainie niska masa urodzeniowa (< 1500 g) urodzonych w latach 2006-2010 w I Katedrze Ginekologii i Poloznictwa UM W Lodzi.

UNLABELLED: Despite better care pregnant women receive nowadays, preterm birth and prematurity remain to be the reason of many complications and high mortality of neonates. OBJECTIVE: The goal was to analyze the indications for cesarean sections delivery for very low birthweight (<1500 g) newborns delivered in the I Department Gynecology and Obstetrics, Medical University in Lodz. MATERIAL: The data from 560 preterm caesarean sections were analyzed. Detailed analysis referring to 120 cesarean sections resulting in deliveries of very low birthweight neonates was performed. Maternal age, parity neonatal weight and gestational age were assessed. The authors also assessed the number of cesarean sections performed for extremely low birthweight newborns, in particularly years and the rate of the indications in the groups of gestational age. RESULTS: The greatest number of the cesarean sections was done between 26-35 years of age of the patients (68,4%) in 28-32 weeks of gestation (53,3%). The rate of cesarean section performed for very low birthweight neonates was 2,3% of preterm caesarean sections. Fetal growth restriction (IUGR) and the symptoms of intrauterine hypoxia were the indications for cesarean sections in 33,4%, multiple pregnancy in 17,5%, abnormal fetal presentation in 15,8%, intrauterine infection in 13,3% and placental abruption in 11,7% of cases. The rate of the other indications was 11,7% of cases. CONCLUSIONS: In our material the most frequent indication for the cesarean section for very low birthweight neonates was fetal growth restriction with the symptoms of intrauterine hypoxia.

[Course of pregnancy and delivery in a patient with ovarian cancer after conservative surgical treatment--case report]. / Przebieg ciazy i porodu u pacientki po leczeniu oszczedzajacym z powodu raka jajnika--opis przypadku.

Ovarian cancer is most often recognized in women at a menopausal age. It rarely appears in young women, however it can coexists with pregnancy or even precede their reproductive activity. Therefore, the exists a risk that the advancement of the illness or the course of treatment will prevent them from having children. The aim of the study is to describe and present the case of a 30-year-old patient treated conservatively for the cancer of the ovary, the course of pregnancy and the way of delivery.

[The role of physiotherapy in selected gynecological disorders]. / Znaczenie zabiegów z zakresu fizjoterapii w wybranych schorzeniach ginekologicznych.

Physical training is a method supporting pharmacological and surgical treatment by shortening the time of recovery and effectiveness of the entire treatment. Many kinds of such methods, despite their availability remain unpopular and unused. The aim of the following study was to present possibilities of aiding the processes of curing by means of new physical methods. Guidelines for the treatment of adnexitis and rehabilitation after operative treatment were presented.

[Concentration of selected biochemical parameters in blood of pregnant women infected by HPV 16 and 18]. / Ocena stezenia wybranych parametrów biochemicznych w surowicy kobiet ciezarnych z zakazeniem HPV 16 i 18.

UNLABELLED: Asymptomatic HPV infection in pregnant women may be connected with changes of pro-inflammatory cytokines and proteolytic enzymes which may condition the persistence of infection during pregnancy. AIM: The main aim of the study was to evaluate the concentration of interleukin-1, TNF-alpha and alpha-1 antitrypsin in pregnant women infected by oncogenic types HPV. MATERIALS AND METHOD: The study was conducted in 2008-2009 at the Department of Obstetrics and Gynecology Medical University Lodz, on pregnant women in the third trimester of pregnancy The study group consisted on 19 pregnant women HPV-16, -18 infected. The control group consisted on 34 pregnant women at the same gestational age, HPV-negative. The concentration of interleukin-1, TNF-alpha and alpha-1 antitripsin was estimated in blood. RESULTS: The results of concentration interleukin-1, TNF-alpha and alpha-1 antitrypsin were similar in both groups of pregnant women. CONCLUSIONS: High risk HPV infection has no influence on the concentration of pro- inflammatory cytokines. In HPV infection during pregnancy the anti proteolytic defense did not decrease.

[Physiotherapy in obstetrics]. / Fizjoterapia w poloznictwie.

Physical activity during pregnancy, active preparation for the delivery and rehabilitation after delivery are factors that can influence the quality of life of a woman at those stages of life. Treatment and prevention of leg edemas decreases the risk of hospitalization. Kinezytherapy helps pregnant women to prevent obesity and stay in good physical condition. Physiological changes in skeleton and muscle system may be the reason of pain during pregnancy and physiotherapy may effectively prevent it. Preparation for the delivery by physical activity, kinezytheraphy and respiratory exercises increase awareness and help a pregnant woman to participated more actively in the act of the delivery.

The influence of steroid sex hormones on collagen composition in post-operative wounds after long-term treatment with anticoagulants.

BACKGROUND: Wound healing is a complicated process, mainly dependent on neovascularisation of tissue. New synthesis of collagen filaments is also very important in proper healing of wounds. Widespread use of anticoagulant medication in operative specialties influences the way post operative wounds heal and calls for continuous efforts to find new ways of modifying the findings about this process. AIM: The main aim of the study was to estimate the influence of early treatment of steroid sex hormones on the healing process of wounds in rats after a long-term anticoagulant therapy Material and methods. The study was conducted on a model of an animal at the Department of High Risk Pregnancy Medical University of Lodz between 2004-2006. The Wistar rats were used for the study The influence of heparin and steroid hormones on collagen synthesis in post operative wounds in female rats after bilateral ovariectomy and the intensity of the composition of collagen in prolene mesh in vivo were estimated. RESULTS: The healing process of post operative wounds in the control group was connected with an increased concentration of collagen in the scar region. Progesterone has no influence on heparin action with respect to total collagen concentration, estrogen administration significantly increased the total concentration of collagen in wounds of rats treated with low-molecular-weight heparin. CONCLUSIONS: 1. Steroid sex hormones in rats after bilateral ovariectomy treated with low-molecular-weight heparin have major influence on post operative wound healing process. 2. Estradiol supplementation in post operative period improves the effect of heparin on the quality of the wound.

[The course of pregnancy and perinatal period in overweight or obese pregnant women with regard to the condition of the newborn--own experience]. / Wplyw nadwagi lub otylosci u ciezarnych na przebieg ciazy i okresu okoloporodowego z uwzglednieniem stanu urodzeniowego noworodka w oparciu o material kliniczny.

OBJECTIVES: The aim of the study was to estimate whether obesity and overweight influence the course of a pregnancy and labor and to assess the condition of a newborn. MATERIAL AND METHODS: 92 cases of pregnant women with singleton pregnancy were analyzed and assessed. The patients were divided into three groups according to their body mass index. Women with BMI between 18.5 and 24.9 comprised the first group (controls), those with BMI from 25.0 to 29.9--the second group (overweight but not obese) and those with BMI of 30 and above--the third one (obese). RESULTS: Average weight gain in the course of a pregnancy was significantly lower in the obese group whereas average blood pressure in obese women was significantly higher than in the control group. Gestational complications, such as hypertension and gestational edemas were more common in the third group. Birth weight and neonatal outcome were similar in all groups. CONCLUSIONS: 1. There is a higher risk of complications in pregnancy in overweight and obese women. 2. Obesity of women may worsen the outcome of the neonate.

[The assessment of leptin concentration and Vascular Endothelial Growth Factor (VEGF) in relation to the body mass index since 20th week of pregnancy]. / Ocena stezenia leptyny oraz sródblonkowo- naczyniowego czynnika wzrostu od 20 tygodnia ciazy, w zaleznosci od wskaznika masy ciala.

UNLABELLED: High body mass index and obesity in pregnancy signify an increased obstetrical risk. Obesity before pregnancy qualifies a patient into the group that demands more attention from the obstetrician. Leptin and VEGF are among numerous factors that influence the pregnancy course and outcome. MATERIAL AND METHOD: The study was conducted in a group of pregnant women from 20-24 weeks of gestation in High Risk Pregnancy Clinic, Medical University Lodz, between 2005-2007. The study group consisted of 30 pregnant women with BMI > or =30 and the control group consisted of 25 pregnant women at the same gestational age and BMI < or =25. Concentrations of leptin and VEGF were measured in venous blood every 4 weeks. RESULTS: More body mass gain during pregnancy was observed in the group of women with BMI > or =30 when compared to the group of BMI < or =25. Mean value of leptin was higher in the group of obese women. No difference was found in leptin concentration measured every 4 weeks. The correlation between leptin concentration and BMI was found in the group of obese women. The concentration of VEGF was higher in controls than in the group of obese women. The mean concentration of VEGF measured every 4 weeks in both groups was similar. The highest values of VEGF were found in 20-24 and 30-34 weeks of pregnancy in women with normal BMI. CONCLUSIONS: 1. The synthesis of leptin depends on body mass, not the duration of pregnancy. 2. Obesity in pregnancy is connected with decreased VEGF synthesis.

[Obstetric hysterectomy in a patient with uterine myoma of uterus duplex--case report]. / Histerektomia poloznicza u pacjentki z miesniakiem macicy podwójnej--opis przypadku.

A case of a 43-year-old multipara in 36th week of pregnancy with a duplicate uterus and uterine myoma with 15 centimeters diameter has been presented in the article. The aim of the study was to present her obstetric history, course of pregnancy and delivery mode.

[The Lesniowski-Crohn disease and pregnancy--case report]. / Przebieg ciazy w chorobie Lesniowskiego-Crohna--opis przypadku.

Lesniowski-Crohn disease is an inflammatory process, involving all layers of the intestine, mesentery and regional lymph nodes. During the development of the disease, a thickening of the intestine wall, stricture of its lumen and adhesions have been observed. The aim of the study was to present the case of a 27-year-old pregnant woman with Crohn's disease, a very rare complication of gestation.

[24-hour Holter measurement of blood pressure in pregnant women and effectiveness of the treatment]. / Ocena przydatnosci 24-godzinnego monitorowania cisnmienia tetniczego u ciezarnych metoda Holtera, dla poprawy efektów leczenia nadcisnienia tetniczego.

OBJECTIVES: Hypertension remains a very serious obstetric problem and a severe pregnancy complication. Hypertension in pregnancy influences the intrauterine fetal growth. Proper monitoring of antihypertensive therapy effects enables us to make suitable modifications of the treatment. The aim of the study was to evaluate the benefits of 24-hour Holter arterial pressure monitoring method in hypertensive pregnant women. MATERIAL AND METHODS: Pregnant women hospitalized and treated for hypertension in the Department of Pathology of Pregnancy of Medical University of Lódz were investigated in the study. Two groups were compared, namely: the control group--pregnant hypertensive women with blood pressure controlled 4 times a day and a study group with 24-hr blood pressure control. RESULTS: In the study group examined by 24-hr arterial pressure monitoring, measured, values of blood pressure during the treatment was significantly higher. This observation shows the necessity to increase doses of antihypertensive agents. CONCLUSION: 24-hr arterial pressure monitoring allows us to administer a more precise dosage of antihypertensive drugs than several arterial blood pressure measurements per day.

HLHS--congenital heart defect in High Risk Pregnancy Unit in 2001-2007.

BACKGROUND: HLHS (hypoplastic left heart syndrome) is a serious congenital heart defect. In neonates with congenital heart disease HLHS accounts for nearly 25% of neonatal deaths. The etiology of HLHS is unknown. At present we expect to have those cases diagnosed in the second trimester of pregnancy. AIM: The main aim was to find the rate and outcome of the congenital heart defect--left heart hypoplasia (HLHS). MATERIAL AND METHODS: All cases of this heart defect found in the High Risk Pregnancy Clinic in 2001-2007 were presented. Twice the congenital malformation was diagnosed after delivery and once during pregnancy--in the second trimester. All babies were delivered between 38 and 39 weeks of pregnancy, one by the spontaneous normal delivery, one by elective caesarean section and one by emergency caesarean section because of fetal distress during the delivery. All of the newborns were transported to the Pediatric Cardio surgery Unit of M.U. and operated in first weeks after delivery. RESULTS: In two cases the operation was complicated and children died due to the cardiac arrest. One of the babies died before surgical correction. Two of the women, whose babies died after the operation gave birth to healthy newborns with no cardiac abnormalities. CONCLUSION: The HLHS is the most serious heart congenital malformation diagnosed often after the delivery because of lack of sufficient diagnostic system in healthy women. The prognosis for the children is bad, but the chance of giving birth to healthy children in the future is good.

[Influence of parity on the body mass of neonates]. / Wplyw dzietnosci matki na mase urodzeniowa noworodka.

OBJECTIVES: The purpose of the study was to determine whether there exists a positive correlation between the mother's parity and the child's weight on delivery. MATERIALS AND METHODS: A retrospective study has been conducted on a selected group of 86 multiriparas with three deliveries. Only in term babies of healthy mothers were taken into consideration. Data derived from cases has been analyzed by means of Microsoft Excel and Statistica 6.0 software. RESULTS: In 65.1% of the cases, the birth weight of the second neonate exceeded the weight of the first one. The rate diminishes to 51.2% when we compare the third child with the second. In 2.3% of the records no changes have been observed. The abovementioned criteria enabled us to form three groups out of the initial cohort and perform further analysis. CONCLUSIONS: Significant correlation between birth weight of the first and second newborn has been found. No such correlation was found in the case of the second compared to the third delivery.

[The analysis of the uterine cervix biocenosis in pregnant women]. / Analiza biocenozy kanalu szyjki macicy u ciezarnych.

OBJECTIVES: Infections of the vagina and the uterine cervix are some of the most frequently diagnosed and treated complications during pregnancy. AIMS: The aim of the study was to carry out biocenosis of the uterine cervix among pregnant women and the assessment of the resistance of the previously isolated types of bacteria to antibiotics. MATERIAL AND METHODS: The study was done in a group of 244 pregnant women, aged from 17 to 43, hospitalized and treated for various reasons in the Department of Pathology of Pregnancy at Medical University in Lódz. The biocenosis of the uterine cervix and the results of microbiological bacterial culture have been analyzed and the sensitivity of bacterial flora on the applied antibiotics has been assessed. RESULTS: Enterococcus faecalis, Escherichia coli and Staphylococcus epidermidis were the most frequent bacteria found in the smear from the uterine cervix. Negative culture was obtained in 2% of the pregnant women. The most frequently observed resistance to antibiotics manifested itself in case of amoxicillin, ampicillin, penicillin, erythromycin, clarithromycin and azithromycin. The bacteria showed least resistance to cephalosporins and fluoroquinolones. Staphylococcus epidermidis showed the highest resistance to antibiotics in general. CONCLUSIONS: In cases of bacterial vaginal infections, with unknown sensitivity to bacteria, treatment the use of cephalosporins is highly recommended.

[Chlamydia trachomatis infection and bacterial analysis in pregnant women in II and III trimester of pregnancy]. / Ocena obecnosci zakazenia Chlamydia trachomatis oraz ocena flory bakteryjnej u kobiet ciezarnych w II i III trymestrze ciazy.

UNLABELLED: Chlamydia trachomatis (CT) infection during pregnancy might be the reason of an increased risk of preterm delivery and premature rupture of membranes. CT could also be responsible for the presence of intrauterine growth restriction, chorionamnionitis and post partum endometritis. It is the most common sexually transmitted disease. The infection may be the reason for PID and consequently even sterility. CT infection could be asymptomatic and the most frequently seen symptom is cervicitis in Pap smears. AIM: The main aim of the study was to estimate the frequency of CT infection in pregnant women, the presence of inflammatory symptoms in Pap-smears, abnormal bacterial status of the vagina and the risk of preterm delivery. MATERIAL AND METHODS: The study was conducted between the years 2005 and 2007 on hospitalized women in The Clinic of High Risk Pregnancy. The first group consisted of 200 pregnant women in II trimester and the second of 200 pregnant women in III trimester of pregnancy. In case of each patient the indication for hospitalization was as increased risk of preterm delivery. The Pap-smears, bacterial smear and immunochromatographic test for CT were done on the first day of the treatment from the border line of the cervical epithelium. The immunochromatographic method, despite its low specificity, lower than PCR (polymerase chain reaction), is useful because of low costs, simplicity of the method and ease of the diagnosis. In case of positive immunochromatographic Ct test, PCR CT analysis should be conducted to make sure the diagnosis is correct. The Pap-smear result suggesting inflammatory process of dysplastic changes was the reason for local antibacterial treatment after which a control smear was done. Bacterial analysis done from external ostium showed patogenic and cohabitants bacteria and resistance to antibiotics. The written consent for the study was obtained. RESULTS: In the group of pregnant women there were no pathological-alert bacteria smears. In the second group the alert bacteria was found in 3 cases (1.5). In 32% of the first group in 27% of cases inflammatory changes in Pap-smears were found. No positive result of CT was found in either of the groups. The symptoms of preterm delivery were found in 78% members of the first group and in 84% cases of the second group. Preterm delivery occurred in 4 cases in the first group (2%) and 6 cases in the second group (3%). CONCLUSIONS: 1. In analyzed groups of pregnant women the CT infection was excluded. 2. The inflammatory symptoms on uterine cervix were not connected with CT infection.

Subcutaneous low molecular weight heparin administration promotes wound healing in rats.

The influence of subcutaneous low molecular weight heparin (LMWH) compared with physiologic saline on the healing of abdominal wounds with and without prolene mesh was studied in rats. The collagen concentration was determined in the wound tissue and in prolene mesh 14, 21, 28 and 42 days after the skin incision in controls and in two groups of rats treated either with LMWH for 7 (I group) or 14 (II group) days after skin incision and prolene insertion. LMWH administration resulted in a significant increase of collagen content both in wound and in prolene mesh in total dose-dependent manner.