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1.
Childs Nerv Syst ; 40(2): 381-393, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-37730915

RESUMEN

OBJECTIVE: The challenge of pediatric brain tumor surgery is given due to a relative low prevalence but high heterogeneity in age, localization, and pathology. Improvements of long-term overall survival rates were achieved during the past decades stressing the importance of a multidisciplinary decision process guided by a national treatment protocol. We reviewed the entire spectrum of pediatric brain tumor surgeries from the perspective of an interdisciplinary pediatric neuro-oncology center in Germany. METHODS: Every patient who underwent brain tumor surgery from January 2010 to June 2017 in our Pediatric Neurosurgery department was retrospectively included and evaluated regarding the course of treatment. Perioperative data such as tumor localization, timing of surgery, extent of resection, neuropathological diagnosis, transfusion rates, oncologic and radiation therapy, and neurological follow-up including morbidity and mortality were evaluated. RESULTS: Two hundred ninety-three pediatric brain tumor patients were applicable (age: 8.28 ± 5.62 years, 1.22:1.0 m:f). A total of 531 tumor surgical interventions was performed within these patients (457 tumor resections, 74 tumor biopsies; mean interventions per patient 1.8 ± 1.2). Due to a critical neurologic status, 32 operations (6%) were performed on the day of admission. In 65.2% of all cases, tumor were approached supratentorially. Most frequent diagnoses of the cases were glial tumors (47.8%) and embryonal tumors (17.6%). Preoperative planned extent of resection was achieved in 92.7%. Pre- and postoperative neurologic deficits resolved completely in 30.7%, whereas symptom regressed in 28.6% of surgical interventions. New postoperative neurologic deficit was observed in 10.7%, which resolved or improved in 80% of these cases during 30 days. The mortality rate was 1%. CONCLUSION: We outlined the center perspective of a specialized pediatric neuro-oncological center describing the heterogeneous distribution of cases regarding age-related prevalence, tumor localization, and biology, which requires a high multidisciplinary expertise. The study contributes to define challenges in treating pediatric brain tumors and to develop quality indicators for pediatric neuro-oncological surgery. We assume that an adequate volume load of patients within a interdisciplinary infrastructure is warranted to aim for effective treatment and decent quality of life for the majority of long-term surviving pediatric tumor patients.


Asunto(s)
Neoplasias Encefálicas , Glioma , Adolescente , Niño , Preescolar , Humanos , Neoplasias Encefálicas/patología , Glioma/cirugía , Procedimientos Neuroquirúrgicos/métodos , Calidad de Vida , Estudios Retrospectivos , Resultado del Tratamiento
2.
Clin Genet ; 84(6): 531-8, 2013 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-23425300

RESUMEN

Acrodysostosis is characterized by a peripheral dysostosis that is accompanied by short stature, midface hypoplasia, and developmental delay. Recently, it was shown that heterozygous point mutations in the PRKAR1A gene cause acrodysostosis with hormone resistance. By mutational analysis of the PRKAR1A gene we detected four different mutations (p.Arg368Stop, p.Ala213Thr, p.Tyr373Cys, and p.Arg335Cys) in four of seven affected patients with acrodysostosis. The combination of clinical results, endocrinological parameters and in silico mutation analysis gives evidence to suppose a pathogenic effect of each mutation. This assumption is supported by the de novo origin of these mutations. Apart from typical radiological abnormalities of the hand bones, elevated thyroid stimulating hormone and parathyroid hormone values as well as short stature are the most common findings. Less frequent features are characteristic facial dysmorphisms, sensorineural hearing loss and mild intellectual disability. These results lead to the conclusion that mutations of PKRAR1A are the major molecular cause for acrodysostosis with endocrinological abnormalities. In addition, in our cohort of 44 patients affected with brachydactyly type E (BDE) we detected only one sequence variant of PRKAR1A (p.Asp227Asn) with an unclear effect on protein function. Thus, we conclude that PRKAR1A mutations may play no major role in the pathogenesis of BDE.


Asunto(s)
Subunidad RIalfa de la Proteína Quinasa Dependiente de AMP Cíclico/genética , Disostosis/genética , Discapacidad Intelectual/genética , Mutación , Osteocondrodisplasias/genética , Adolescente , Adulto , Alelos , Niño , Análisis Mutacional de ADN , Disostosis/diagnóstico , Disostosis/metabolismo , Femenino , Huesos de la Mano/diagnóstico por imagen , Huesos de la Mano/patología , Humanos , Discapacidad Intelectual/diagnóstico , Discapacidad Intelectual/metabolismo , Masculino , Osteocondrodisplasias/diagnóstico , Osteocondrodisplasias/metabolismo , Fenotipo , Radiografía , Adulto Joven
3.
J Perinatol ; 31(12): 802-3, 2011 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-22124517

RESUMEN

The amiloride-sensitive epithelial sodium channel, ENaC, is thought to have a major role in clearing fluid from the alveoli immediately after birth. ENaC-α knockout mice die soon after birth from failure to clear their lungs of liquid. We report on a male infant born after 33 weeks of gestation with uneventful postnatal adaptation (Apgar 9/9/9 at 1, 5 and 10 min after birth) who did not require any respiratory support during his first days of life. At nine days of life, he became lethargic and hyperthermic, displaying low Na(+) (126 mmol l(-1)), high K(+) (8.9 mmol l(-1)), high aldosterone (3000 ng l(-1))and high renin (1000 ng l(-1)) plasma concentrations, commensurate with pseudohypoaldosteronism type I. He was found to be homozygous for the c.1678G>A mutation in the SCNN1A gene that codes for the ENaC-α unit. We conclude that clearance of alveolar fluid after birth in humans does not critically depend on ENaC.


Asunto(s)
Canales Epiteliales de Sodio/genética , Enfermedades del Prematuro/genética , Mutación , Seudohipoaldosteronismo/genética , Respiración , Homocigoto , Humanos , Recién Nacido , Recien Nacido Prematuro , Masculino , Seudohipoaldosteronismo/congénito , Seudohipoaldosteronismo/fisiopatología
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