Detalles de la búsqueda
1.
Ceritinib in ALK-rearranged non-small-cell lung cancer.
N Engl J Med
; 370(13): 1189-97, 2014 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24670165
2.
Liquid chromatography tandem mass spectrometry method for the quantitative analysis of ceritinib in human plasma and its application to pharmacokinetic studies.
Anal Bioanal Chem
; 406(28): 7389-96, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25258279
3.
Effect of ceritinib on the pharmacokinetics of coadministered CYP3A and 2C9 substrates: a phase I, multicenter, drug-drug interaction study in patients with ALK + advanced tumors.
Cancer Chemother Pharmacol
; 87(4): 475-486, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33394101
4.
Phase 1/2 study of ceritinib in Chinese patients with advanced anaplastic lymphoma kinase-rearranged non-small cell lung cancer previously treated with crizotinib: Results from ASCEND-6.
Lung Cancer
; 150: 240-246, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33249379
5.
Ceritinib plus Nivolumab in Patients with Advanced ALK-Rearranged Non-Small Cell Lung Cancer: Results of an Open-Label, Multicenter, Phase 1B Study.
J Thorac Oncol
; 15(3): 392-403, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31634667
6.
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.
Am J Physiol Endocrinol Metab
; 297(5): E1105-14, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19706786
7.
Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys.
J Pharmacol Exp Ther
; 329(1): 102-11, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19129372
8.
Intraosseous glomus tumor treated by toe-to-finger transfer: case report.
J Hand Surg Am
; 34(4): 710-4, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19345875
9.
Application of time-dependent modeling for the exposure-efficacy analysis of ceritinib in untreated ALK-rearranged advanced NSCLC patients.
Cancer Chemother Pharmacol
; 84(3): 501-511, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31020351
10.
Efficacy and Safety of Ceritinib (450 mg/d or 600 mg/d) With Food Versus 750-mg/d Fasted in Patients With ALK Receptor Tyrosine Kinase (ALK)-Positive NSCLC: Primary Efficacy Results From the ASCEND-8 Study.
J Thorac Oncol
; 14(7): 1255-1265, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30851442
11.
Population Pharmacokinetics of Ceritinib in Adult Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase.
J Clin Pharmacol
; 57(5): 652-662, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27922734
12.
Assessment of drug-drug interaction potential between ceritinib and proton pump inhibitors in healthy subjects and in patients with ALK-positive non-small cell lung cancer.
Cancer Chemother Pharmacol
; 79(6): 1119-1128, 2017 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-28424965
13.
ASCEND-8: A Randomized Phase 1 Study of Ceritinib, 450 mg or 600 mg, Taken with a Low-Fat Meal versus 750 mg in Fasted State in Patients with Anaplastic Lymphoma Kinase (ALK)-Rearranged Metastatic Non-Small Cell Lung Cancer (NSCLC).
J Thorac Oncol
; 12(9): 1357-1367, 2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28729021
14.
Predation by Red Foxes (Vulpes vulpes) at an Outdoor Piggery.
Animals (Basel)
; 6(10)2016 Oct 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27740601
15.
Effects of meal type on the oral bioavailability of the ALK inhibitor ceritinib in healthy adult subjects.
J Clin Pharmacol
; 56(5): 559-66, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26272586
16.
Diagnostic capability of low- versus high-field magnetic resonance imaging for lumbar degenerative disease.
Spine (Phila Pa 1976)
; 40(6): 382-91, 2015 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25584942
17.
Mechanistic modeling of antigen sink effect for mavrilimumab following intravenous administration in patients with rheumatoid arthritis.
J Clin Pharmacol
; 52(8): 1150-61, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21947370
18.
Pharmacokinetic and pharmacodynamic modeling of a monoclonal antibody antagonist of glucagon receptor in male ob/ob mice.
AAPS J
; 11(4): 700-9, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19851873
19.
Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems.
J Pharmacol Exp Ther
; 316(2): 762-71, 2006 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-16258024
20.
Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism.
Drug Metab Dispos
; 34(7): 1175-81, 2006 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-16624870