Detalles de la búsqueda
1.
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022.
Altern Lab Anim
; 51(4): 263-288, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-37282515
2.
Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results with Acetaminophen, Amiodarone, Cyclophosphamide, Ketoconazole, Nefazodone, and Troglitazone.
Drug Metab Dispos
; 50(2): 140-149, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34750194
3.
Messenger RNA Expression of Albumin, Transferrin, Transthyretin, Asialoglycoprotein Receptor, Cytochrome P450 Isoform, Uptake Transporter, and Efflux Transporter Genes as a Function of Culture Duration in Prolonged Cultured Cryopreserved Human Hepatocytes as Collagen-Matrigel Sandwich Cultures: Evidence for Redifferentiation upon Prolonged Culturing.
Drug Metab Dispos
; 49(9): 790-802, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34135090
4.
In Vitro Human Cell-Based Experimental Models for the Evaluation of Enteric Metabolism and Drug Interaction Potential of Drugs and Natural Products.
Drug Metab Dispos
; 48(10): 980-992, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32636209
5.
Application of Cryopreserved Human Intestinal Mucosa and Cryopreserved Human Enterocytes in the Evaluation of Herb-Drug Interactions: Evaluation of CYP3A Inhibitory Potential of Grapefruit Juice and Commercial Formulations of Twenty-Nine Herbal Supplements.
Drug Metab Dispos
; 48(10): 1084-1091, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32719085
6.
Regional Proteomic Quantification of Clinically Relevant Non-Cytochrome P450 Enzymes along the Human Small Intestine.
Drug Metab Dispos
; 48(7): 528-536, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32350063
7.
In vitro evaluation of the metabolic stability of nine fragrance chemicals in trout and human hepatocytes.
J Appl Toxicol
; 40(10): 1421-1434, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32488907
8.
Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes).
Drug Metab Dispos
; 47(10): 1032-1039, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31375472
9.
Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans.
Xenobiotica
; 49(7): 852-862, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-30132394
10.
A Novel In Vitro Experimental System for the Evaluation of Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Cryopreserved Human Hepatocytes).
Drug Metab Dispos
; 46(11): 1608-1616, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29363498
11.
Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity.
Drug Metab Dispos
; 46(11): 1562-1571, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30006371
12.
Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice.
Biopharm Drug Dispos
; 39(2): 99-115, 2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29243851
13.
Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.
J Pharmacol Exp Ther
; 360(1): 174-191, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27789682
14.
Human Enterocytes as an In Vitro Model for the Evaluation of Intestinal Drug Metabolism: Characterization of Drug-Metabolizing Enzyme Activities of Cryopreserved Human Enterocytes from Twenty-Four Donors.
Drug Metab Dispos
; 45(6): 686-691, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28396528
15.
Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters.
Drug Metab Dispos
; 44(9): 1524-35, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27342868
16.
In situ allicin generation using targeted alliinase delivery for inhibition of MIA PaCa-2 cells via epigenetic changes, oxidative stress and cyclin-dependent kinase inhibitor (CDKI) expression.
Apoptosis
; 20(10): 1388-409, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26286853
17.
Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice.
Hepatology
; 60(5): 1741-52, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-24723460
18.
Prolonged cultured human hepatocytes as an in vitro experimental system for the evaluation of potency and duration of activity of RNA therapeutics: Demonstration of prolonged duration of gene silencing effects of a GalNAc-conjugated human hypoxanthine phosphoribosyl transferase (HPRT1) siRNA.
Biochem Pharmacol
; 189: 114374, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33358826
19.
Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes.
J Pharm Sci
; 110(1): 376-387, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33122051
20.
3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration.
Clin Transl Sci
; 14(5): 1659-1680, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33982436