Effectiveness of estrogen treatment before transcervical resection of adhesions on moderate and severe uterine adhesion patients.

Intrauterine adhesion (IUA), also known as Asherman's syndrome, is a common disease for among women. The extent of adhesion and pre-surgery hormone therapy greatly affects the function of uterine cavity. This current study investigates the association of different doses of estrogen before transcervical resection of adhesions (TCRA) surgery and clinical outcome in serious IUA. About 120 newly diagnostic serious IUA patients who underwent TCRA were randomly divided into three study groups: Estradiol valerate (progynova) 3 or 9 mg per diet before surgery and the control group. Follow-up hysteroscopy checkups were taken in 1- and 3-month post-operation. The effective power of 9 mg group was significantly higher than other groups. The 9 mg group achieved the best menstrual recovery rate in all study groups compared with the other two groups in 6 months post-operatively (p < 0.05). Our results confirmed estradiol valerateas an alternative effective drug for the prevention of IUAs before and after hysteroscopic surgery.

[Primary application and evaluation of a technology for objective measurement of accommodation of human eyes].

OBJECTIVE: To evaluate the practical value of a new technology for objective measurement of accommodation of human eyes. METHODS: It was a comparative study of some techniques for measuring the accommodation of human eyes. Twenty-six outpatients (20 male, 6 female, 10-37 years old) that were suspected to be abnormal in accommodation were examined with Nidek ARK-730 (with software AA-1 inside). The measurement results from the instrument were compared by Kappa test with the clinical impression and comprehensive impression based on measurement results and clinical information. RESULTS: The abnormality rate of accommodation of the patients were 61.5%, 46.2%, 61.5% from the instrument, clinical impression and comprehensive impression respectively. The agreement was weak with Kappa value 0.244 between results from the instrument and clinical impression. The agreement was mild with Kappa value 0.513 between results from the instrument and comprehensive impression. The agreement was high with Kappa value 0.698 between results from clinical impression and comprehensive impression. CONCLUSIONS: The new technology is a progress and complementary to the traditional technology for accommodation examination. With the help of the new technology, some complicated patients could be diagnosed. The diagnose procedure of the instrument remains to be improved. The comprehensive impression based on measurement results and clinical information has more practical value.

Uterine adenomatoid tumor: a clinicopathologic study of 102 cases.

OBJECTIVE: Uterine adenomatoid tumors (UATs) are tubercle without significant clinical features. The study aims to summarize the clinicopathological characteristics of UATs to improve diagnostic accuracy. METHODS: Between January 2014 and December 2015, 4326 uterine specimens were collected from patients who received hysterectomy or myomectomy, of which 102 cases were pathologically confirmed as UATs. The clinical features, pathological parameters and immunohistochemical staining were analyzed. RESULTS: One hundred and two UATs were identified by gross and microscopic examination, which accounts for 2.4% of all the uterine tumors. UATs were usually located in the uterus myometrium, near the serosa or cornua. Most of them were solitary, without an enveloping membrane or clear demarcation. Microscopically, typical features were glandular structures and cavities with various sizes and shapes found within the hyperplastic smooth muscle tissues. Immunohistochemical staining showed that all tumors were positive for HBME-1 and CK (pan). Most of them were positive for CR (89.6%) and D2-40 (92.4%), negative for CD31 and CEA, while cast-off cells in glandular cavities and lymphocytes were positive for LCA. CONCLUSION: Adenomatoid tumors are not very rare in the uterus. The diagnosis of UATs can be improved by carefully gross and microscopic examination. Immnohistachemical staining is helpful for diagnosis and differential diagnosis of UATs.

Biomechanical characteristics investigation on long-term free graft with expanded porcine skin.

BACKGROUND: Free skin graft has to be used when the large area skin are burned. The objective of this study is to quantify the influence of free graft and expansion on the skin biomechanical remodeling. METHOD: Four white pigs (weighing from 17 kg to 23 kg) were used. Two 180 ml rectangle expanders were aseptically placed beneath the skin on the back of each pig. Four normal skin flaps and four expanded skin flaps were incised from the foreside back of each pig. Two normal skin flaps and two expanded skin flaps were then grafted to rearward back of the pig. Stress-strain relationship, stress relaxation and creep characters in normal skin: N(n=8), expanded skin without graft: E(n=8), normal skin with free graft after three months: NG(n=8) and expanded skin with free graft after three months: EG(n=8) were measured by using Instron material testing machine. FINDINGS: The strains at 3.5 MPa stress (mean (SD)) are 0.4436(0.1760), 0.4851(0.1401), 0.7750(0.1984) and 0.5854(0.0655) respectively in N, E, NG and EG groups. The maximum relaxations (mean (SD)) are 0.6324(0.0169), 0.6279(0.0401), 0.5630(0.0170) and 0.6057(0.0883) in N, E, NG and EG groups, respectively. The maximum creeps (mean (SD)) are 1.0876(0.0086), 1.1037(0.0116), 1.1948(0.0394) and 1.1328(0.0223) in N, E, NG and EG groups. INTERPRETATION: The biomechanical characteristics of free graft with expanded skin after three months have no significant difference with the normal skin, expansion skin and free graft with normal skin after three months (P>0.05). The free graft and expansion have no significant influence on the skin biomechanical remodeling.