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1.
Sensors (Basel) ; 23(10)2023 May 14.
Artículo en Inglés | MEDLINE | ID: mdl-37430664

RESUMEN

Human activity recognition (HAR) is becoming increasingly important, especially with the growing number of elderly people living at home. However, most sensors, such as cameras, do not perform well in low-light environments. To address this issue, we designed a HAR system that combines a camera and a millimeter wave radar, taking advantage of each sensor and a fusion algorithm to distinguish between confusing human activities and to improve accuracy in low-light settings. To extract the spatial and temporal features contained in the multisensor fusion data, we designed an improved CNN-LSTM model. In addition, three data fusion algorithms were studied and investigated. Compared to camera data in low-light environments, the fusion data significantly improved the HAR accuracy by at least 26.68%, 19.87%, and 21.92% under the data level fusion algorithm, feature level fusion algorithm, and decision level fusion algorithm, respectively. Moreover, the data level fusion algorithm also resulted in a reduction of the best misclassification rate to 2%~6%. These findings suggest that the proposed system has the potential to enhance the accuracy of HAR in low-light environments and to decrease human activity misclassification rates.


Asunto(s)
Algoritmos , Actividades Humanas , Anciano , Humanos , Radar , Reconocimiento en Psicología
2.
Sensors (Basel) ; 22(15)2022 Jul 23.
Artículo en Inglés | MEDLINE | ID: mdl-35897997

RESUMEN

Noise is a common problem in wearable electrocardiogram (ECG) monitoring systems because the presence of noise can corrupt the ECG waveform causing inaccurate signal interpretation. By comparison with electromagnetic interference and its minimization, the reduction of motion artifact is more difficult and challenging because its time-frequency characteristics are unpredictable. Based on the characteristics of motion artifacts, this work uses adaptive filtering, a specially designed ECG device, and an Impedance Pneumography (IP) data acquisition system to combat motion artifacts. The newly designed ECG-IP acquisition system maximizes signal correlation by measuring both ECG and IP signals simultaneously using the same pair of electrodes. Signal comparison investigations between ECG and IP signals under five different body motions were carried out, and the Pearson Correlation Coefficient |r| was higher than 0.6 in all cases, indicating a good correlation. To optimize the performance of adaptive motion artifact reduction, the IP signal was filtered to a 5 Hz low-pass filter and then fed into a Recursive Least Squares (RLS) adaptive filter as a reference input signal. The performance of the proposed motion artifact reduction method was evaluated subjectively and objectively, and the results proved that the method could suppress the motion artifacts and achieve minimal distortion to the denoised ECG signal.


Asunto(s)
Artefactos , Dispositivos Electrónicos Vestibles , Algoritmos , Impedancia Eléctrica , Electrocardiografía/métodos , Movimiento (Física) , Procesamiento de Señales Asistido por Computador
3.
Zhongguo Yi Liao Qi Xie Za Zhi ; 45(3): 288-291, 2021 Jun 08.
Artículo en Zh | MEDLINE | ID: mdl-34096238

RESUMEN

OBJECTIVE: The design and development of split memory alloy sternum bone plate are discussed, and the effect of split memory alloy sternum bone plate internal fixation in the treatment of sternal fractures are analysed. METHODS: The structure of the product is designed according to the anatomy and physiological characteristics of human bones, and the cross section shape of the product is designed according to the cross section shape of human bones. Internal fixation is effective in the treatment of sternal fracture. RESULTS: The split memory alloy sternal plate was successfully designed and developed, and all the patients with sternal fractures treated by internal fixation were clinically healed, the hospitalization and fracture healing time were significantly shortened, and no obvious complications occurred. CONCLUSIONS: The application of split memory alloy sternal plate internal fixation in the treatment of sternal fracture has the advantages of small trauma, simple operation, safety, reliable fixation, good histocompatibility and less complications, and is conducive to promoting fracture healing and respiratory function improvement.


Asunto(s)
Aleaciones , Placas Óseas , Fijación Interna de Fracturas , Curación de Fractura , Humanos , Esternón/cirugía
4.
Environ Geochem Health ; 42(5): 1291-1303, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-31515640

RESUMEN

This study focused on the oral bioaccessibility and children health risks of metal(loid)s (As, Cd, Cr, Cu, Ni, Pb and Zn) in soil/indoor dust of school and households from Lanzhou, China. The simple bioaccessibility extraction test method was applied to assess bioaccessibility, and children's health risk was assessed via statistical modeling (hazard quotients, hazard index and incremental lifetime carcinogenic risk). Metal(loid) content and bioaccessibility in indoor dust samples were significantly higher than those in corresponding soil samples (p < 0.05). The order for mean values of bioaccessibility of the elements in soil was as follows: Cd (57.1%) > Zn (44.6%) > Pb (39.9%) > Cu (33.2%) > Ni (12.4%) > Cr (5.3%) > As (4.4%), while for indoor dust, the order was: As (73.0%) > Cd (68.4%) > Pb (63.3%) > Zn (60.4%) > Cu (36.5%) > Ni (25.2%) > Cr (13.6%). The Pearson correlation coefficient showed that metal(loid) bioaccessibility was in general significantly negatively correlated to the Al, Fe and Mn contents. Neither noncarcinogenic nor carcinogenic risks exceeded the tolerance interval for 3-5- and 6-9-year-old children for all elements. They both were mostly attributed to As considering metal(loid)s types and to school indoor dust considering sources. Therefore, maintaining interior sanitation would be an effective measure to reduce the potential health effects of indoor dust on children.


Asunto(s)
Metaloides/farmacocinética , Metaloides/toxicidad , Metales/farmacocinética , Metales/toxicidad , Medición de Riesgo/métodos , Contaminación del Aire Interior/efectos adversos , Contaminación del Aire Interior/análisis , Carcinógenos/farmacocinética , Carcinógenos/toxicidad , Niño , Preescolar , China , Polvo/análisis , Exposición a Riesgos Ambientales/efectos adversos , Exposición a Riesgos Ambientales/análisis , Monitoreo del Ambiente/métodos , Humanos , Metaloides/análisis , Metales/análisis , Metales Pesados/análisis , Población Rural , Instituciones Académicas , Contaminantes del Suelo/análisis , Contaminantes del Suelo/farmacocinética , Contaminantes del Suelo/toxicidad , Población Urbana
5.
Ecotoxicol Environ Saf ; 186: 109748, 2019 Dec 30.
Artículo en Inglés | MEDLINE | ID: mdl-31606640

RESUMEN

Oral ingestion is the main exposure pathway through which humans ingest trace metals in the soil, particularly for children. Metals in different soil particle size fractions may vary in terms of concentration and properties. Urban school/kindergarten soil samples were collected from three cities: Lanzhou in northwest China, Wuhan in central China, and Shenzhen in southeast China. Soil samples were classified according to particle size (<63 µm, 63-150 µm, 150-250 µm, and 250-2000 µm) to estimate the effects of soil particle size on the total content and bioaccessibility of metals (Cd, Cr, Cu, Ni, Pb, and Zn). Based on the results, we assessed whether the standard size <150 µm (containing < 63 µm and 63-150 µm), recommended by the Technical Review Workgroup (TRW) of the Environmental Protection Agency (EPA), and <250 µm (containing < 63 µm, 63-150 µm, and 150-250) recommended by the Bioaccessibility Research Group of Europe (BARGE), are suitable where the largest proportion adhering to hands is the finest soil (<63 µm). The results showed that different metals exhibited different relationships between soil particle size and content and between soil particle size and bioaccessibility. Pb and Zn generally exhibited the greatest bioaccessibility in the coarsest particle sizes (250-2000 µm); whereas the highest Ni bioaccessibility occurred in the finest sizes (<63 µm); the bioaccessibility of other metals did not exhibit any obvious relationships with particle size. When assessing health risks using bioaccessible metal content in the recommended soil particle size ranges (<150 µm and <250 µm) and in finer particles (<63 µm), the results for noncarcinogenic risks to children exhibited no obvious difference, while the actual carcinogenic risks may be underestimated with the use of soil particle size ranges < 150 µm and <250 µm. Therefore, when choosing an optimal particle size fraction to evaluate the health risk of oral soil ingestion, we recommend the use of the bioaccessible metal content in <63 µm soil fraction.


Asunto(s)
Salud Infantil , Monitoreo del Ambiente/métodos , Metales Pesados/farmacocinética , Tamaño de la Partícula , Contaminantes del Suelo/farmacocinética , Suelo/química , Oligoelementos/farmacocinética , Disponibilidad Biológica , Niño , China , Ciudades , Monitoreo del Ambiente/normas , Europa (Continente) , Humanos , Metales Pesados/efectos adversos , Metales Pesados/análisis , Neoplasias/etiología , Medición de Riesgo , Contaminantes del Suelo/efectos adversos , Contaminantes del Suelo/análisis , Oligoelementos/efectos adversos , Oligoelementos/análisis
6.
Ecotoxicol Environ Saf ; 126: 14-22, 2016 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-26707184

RESUMEN

Incidental oral ingestion is the main exposure pathway by which human intake contaminants in both soil and indoor dust, and this is especially true for children as they frequently exhibit hand-to-mouth behaviour. Research on comprehensive health risk caused by incidental ingestion of both soil and indoor dust is limited. The aims of this study were to investigate the arsenic concentration and to characterize the health risks due to arsenic (As) exposure via soil and indoor dust in rural and urban areas of Hubei province within central China. Soil and indoor dust samples were collected from schools and residential locations and bioaccessibility of arsenic in these samples was determined by a simplified bioaccessibility extraction test (SBET). The total arsenic content in indoor dust samples was 1.78-2.60 times that measured in soil samples. The mean As bioaccessibility ranged from 75.4% to 83.2% in indoor dust samples and from 13.8% to 20.2% in soil samples. A Pearson's analysis showed that As bioaccessibility was significantly correlated with Fe and Al in soil and indoor dust, respectively, and activity patterns of children were utilised in the assessment of health risk via incidental ingestion of soil and indoor dust. The results suggest no non-carcinogenic health risks (HQ<1) or acceptable carcinogenic health risks (1×10(-6)

Asunto(s)
Contaminación del Aire/análisis , Arsénico/análisis , Polvo/análisis , Exposición a Riesgos Ambientales/análisis , Contaminantes del Suelo/análisis , Contaminación del Aire/efectos adversos , Arsénico/farmacocinética , Bioensayo/métodos , Disponibilidad Biológica , Niño , Preescolar , China , Exposición a Riesgos Ambientales/efectos adversos , Femenino , Humanos , Actividades Recreativas , Masculino , Medición de Riesgo/métodos , Población Rural/estadística & datos numéricos , Contaminantes del Suelo/farmacocinética , Población Urbana/estadística & datos numéricos
7.
Bull Environ Contam Toxicol ; 97(4): 517-20, 2016 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-27485009

RESUMEN

This study continued our previous work (Sai et al. in Bull Environ Contam Toxicol 95:157-163, 2015a) by analysing the effects of simazine on the liver histological structure and metamorphosis in the developing Xenopus laevis. Tadpoles (Nieuwkoop-Faber stage 46) were exposed to simazine at 0.1, 1.2, 11.0 and 100.9 µg/L for 100 days. When tadpoles were exposed to simazine at 11.0 and 100.9 µg/L, an increased mortality and damaged liver tissues were observed together with significant inhibition of percent of X. laevis completing metamorphosis on days 80 and 90 and prolonged time of completing metamorphosis. On the other hand, we found that simazine has no significant effects on liver weight and altered hepatosomatic index. Results of this study may be considered to inform risk assessment of the effects of simazine on the development of X. laevis.


Asunto(s)
Larva/efectos de los fármacos , Larva/crecimiento & desarrollo , Hígado/efectos de los fármacos , Hígado/patología , Metamorfosis Biológica/efectos de los fármacos , Simazina/toxicidad , Xenopus laevis/crecimiento & desarrollo , Animales , Relación Dosis-Respuesta a Droga , Herbicidas/toxicidad , Tamaño de los Órganos/efectos de los fármacos
8.
Bull Environ Contam Toxicol ; 95(2): 157-63, 2015 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-25634327

RESUMEN

Simazine was investigated for gene expression concurrent with simazine-induced phenotype changes during development of male Xenopus laevis. X. laevis tadpoles (Nieuwkoop-Faber stage 46) were exposed to 0.1, 1.2, 11.0 and 100.9 µg/L simazine for 100 days. The results showed that an increased mortality of X. laevis, decreased gonad weight and altered gonadosomatic index of males significantly (p<0.05) when exposed to simazine at 11.0 and 100.9 µg/L. Significant degeneration in testicular tissues was observed when tadpoles were exposed to simazine at 100.9 µg/L. To investigate the molecular mechanisms behind the testicular degeneration by simazine, we evaluated gene expression in animals treated with 100.9 µg/L simazine and found that 1,315 genes were significantly altered (454 upregulated, 861 downregulated). Genes involved in the cell cycle control, and amino acid metabolism pathways were significantly downregulated. These results indicate that simazine affects the related gene expressions which may be helpful for the understanding of the reason for the reproductive toxicity of simazine on male X. laevis.


Asunto(s)
Regulación del Desarrollo de la Expresión Génica/efectos de los fármacos , Herbicidas/toxicidad , Simazina/toxicidad , Testículo/efectos de los fármacos , Proteínas de Xenopus/genética , Animales , Perfilación de la Expresión Génica , Masculino , Reacción en Cadena en Tiempo Real de la Polimerasa , Reproducción , Testículo/patología , Xenopus laevis
9.
Environ Toxicol ; 29(9): 1083-8, 2014 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-23364943

RESUMEN

The aim of this study is to investigate the effects of subchronic exposure to chlorpyrifos on reproductive toxicology of male rats. Forty healthy male rats were divided into four groups: three exposure groups and a control group. Chlorpyrifos was administered orally to male rats at 0, 2.7, 5.4, and 12.8 mg/kg for 90 days to evaluate the toxic alterations in testicular histology, testicular marker enzyme activities and related genes expression levels, sperm dynamics, and testosterone levels. The body weight and the testis weight of animals did not show any significant changes. Chlorpyrifos brought about marked reduction in testicular sperm counts, sperm motility, and significant growth of sperm malformation rate in exposed males. Histopathological examination of testes showed mild to severe degenerative changes in seminiferous tubules at various dose levels. The levels of testosterone (T) showed a decreasing tendency, and there was a statistical difference between the 5.4, 12.8 mg/kg groups, and the control group. The levels of follicle stimulating hormone (FSH) were significantly increased in 5.4 and 12.8 mg/kg groups, but there were no obvious effects on the levels of luteinizing hormone (LH) and estradiol (E2 ). A significant increase in the activities of LDH and LDH-x was observed in chlorpyrifos exposed rats in 5.4 and 12.8 mg/kg groups, but the expression levels of related genes had no significant differences between chlorpyrifos exposure groups and the control group. These results suggest that chlorpyrifos has adverse effects on reproductive system of male rats.


Asunto(s)
Cloropirifos/toxicidad , Insecticidas/toxicidad , Reproducción/efectos de los fármacos , Animales , Secuencia de Bases , Peso Corporal/efectos de los fármacos , Cartilla de ADN , Hormonas Esteroides Gonadales/metabolismo , Gonadotropinas Hipofisarias/metabolismo , L-Lactato Deshidrogenasa/metabolismo , Masculino , Tamaño de los Órganos/efectos de los fármacos , Reacción en Cadena de la Polimerasa , Ratas , Ratas Wistar , Espermatozoides/efectos de los fármacos , Testículo/efectos de los fármacos , Testículo/enzimología
10.
J Environ Sci (China) ; 26(10): 2076-83, 2014 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-25288552

RESUMEN

The optimized production of a novel bioflocculant M-C11 produced by Klebsiella sp. and its application in sludge dewatering were investigated. The optimal medium carbon source, nitrogen source, metal ion, initial pH and culture temperature for the bioflocculant production were glucose, NaNO3, MgSO4, and pH7.0 and 25°C, respectively. A compositional analysis indicated that the purified M-C11 consisted of 91.2% sugar, 4.6% protein and 3.9% nucleic acids (m/m). A Fourier transform infrared spectrum confirmed the presence of carboxyl, hydroxyl, methoxyl and amino groups. The microbial flocculant exhibited excellent pH and thermal stability in a kaolin suspension over a pH range of 4.0 to 8.0 and a temperature range of 20 to 60°C. The optimum bioflocculating activity was observed as 92.37% for 2.56mL M-C11 and 0.37g/L CaCl2 dosages using response surface methodology. The sludge resistance in filtration (SRF) decreased from 11.6×10(12) to 4.7×10(12)m/kg, which indicated that the sludge dewaterability was remarkably enhanced by the bioflocculant conditioning. The sludge dewatering performance conditioned by M-C11 was more efficient than that of inorganic flocculating reagents, such as aluminum sulfate and polymeric aluminum chloride. The bioflocculant has advantages over traditional sludge conditioners due to its lower cost, benign biodegradability and negligible secondary pollution. In addition, the bioflocculant was favorably adapted to the specific sludge pH and salinity.


Asunto(s)
Klebsiella/metabolismo , Aguas del Alcantarillado , Agua , Floculación , Concentración de Iones de Hidrógeno , Microscopía Electrónica de Rastreo , Espectroscopía Infrarroja por Transformada de Fourier , Temperatura
11.
Front Endocrinol (Lausanne) ; 14: 1237934, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-38027178

RESUMEN

Type 2 diabetes mellitus (T2DM) has become a major health problem, threatening the quality of life of nearly 500 million patients worldwide. As a typical multifactorial metabolic disease, T2DM involves the changes and interactions of various metabolic pathways such as carbohydrates, amino acid, and lipids. It has been suggested that metabolites are not only the endpoints of upstream biochemical processes, but also play a critical role as regulators of disease progression. For example, excess free fatty acids can lead to reduced glucose utilization in skeletal muscle and induce insulin resistance; metabolism disorder of branched-chain amino acids contributes to the accumulation of toxic metabolic intermediates, and promotes the dysfunction of ß-cell mitochondria, stress signal transduction, and apoptosis. In this paper, we discuss the role of metabolites in the pathogenesis of T2DM and their potential as biomarkers. Finally, we list the effects of anti-hyperglycemic drugs on serum/plasma metabolic profiles.


Asunto(s)
Diabetes Mellitus Tipo 2 , Resistencia a la Insulina , Humanos , Diabetes Mellitus Tipo 2/metabolismo , Calidad de Vida , Resistencia a la Insulina/fisiología , Aminoácidos de Cadena Ramificada/metabolismo , Hipoglucemiantes/uso terapéutico
12.
J Hazard Mater ; 445: 130528, 2023 Mar 05.
Artículo en Inglés | MEDLINE | ID: mdl-37055956

RESUMEN

Industry in ancient mining areas caused significant heavy metal pollution (HMP) in agricultural soils. This study measured the hazards of specific sources of heavy metals (HMs) in an ancient mining areas agricultural soil. Firstly, we identified the major pollution sources based on the PMF model. Then, the proposed single-factor pollution load index (SPLIzone) and ecological load index (SELIzone) analyzed the integrated pollution and ecological risks of various elements. Finally, the source-specific soil contamination levels and ecological risks were quantified by combining the source assignment and single-factor assessment processes. SPLIzone and SELIzone showed that Cu and Cd were the most contaminated elements. Five factors were determined as the major sources of HMs, including mining, natural, smelting industry, agricultural and traffic sources. The mining sources contributed the most soil contamination (33.73%). However, the largest contributor to ecological risk was the smelting industrial (42.18%). Lower soil contamination may contain higher ecological risk. Smelting industrial and traffic are the most critical sources that need to be controlled at present. This study proposes a quantitative method for assessing the hazards of HM sources, which provides a beneficial reference for the study and management of HMP.

13.
PLoS One ; 18(2): e0279318, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36780490

RESUMEN

To observe the effect of magnesium ion on vascular function in rats after long-term exhaustive exercise. Forty male SD rats were divided into two groups, the control group (CON group, n = 20) and the exhaustive exercise group (EEE group, n = 20). Exhausted rats performed 1W adaptive swimming exercise (6 times/W, 15min/time), and then followed by 3W formal exhaustive exercise intervention. Hematoxylin and eosin (HE) staining was used to detect the morphological changes of rat thoracic aorta. The contents of interleukin-1 ß (IL-1ß) and tumor necrosis factor-α (TNF-α) in serum of rats were determined by enzyme-linked immunosorbent assay (ELISA), and the contents of malondialdehyde (MDA), reactive oxygen species (ROS), nitric oxide (NO) and endothelin 1 (ET-1) in serum of rats were determined by biochemical kit. Vascular ring test detects vascular function. Compared with the CON group, the smooth muscle layer of the EEE group became thicker, the cell arrangement was disordered, and the integrity of endothelial cells was destroyed; the serum Mg2+ in EEE group was decreased; the serum levels of IL-1ß, TNF-α, MDA and ROS in EEE group were significantly higher than those in the CON group (P are all less than 0.05); the serum NO content in EEE group was significantly decreased, and the ratio of NO/ET-1 was significantly decreased. In the exhaustion group, the vasoconstriction response to KCl was increased, and the relaxation response to Ach was weakened, while 4.8mM Mg2+ could significantly improve this phenomenon (P are all less than 0.01). The damage of vascular morphology and function in rats after exhaustion exercise may be related to the significant increase of serum IL-1ß, TNF-α, ROS, MDA and ET-1/NO ratio in rats after exhaustion exercise, while Mg2+ can significantly improve the vasomotor function of rats after exhaustion exercise.


Asunto(s)
Magnesio , Factor de Necrosis Tumoral alfa , Ratas , Masculino , Animales , Ratas Sprague-Dawley , Especies Reactivas de Oxígeno , Células Endoteliales
14.
Artículo en Inglés | MEDLINE | ID: mdl-36673677

RESUMEN

Urban construction land (UCL) change is a significant cause of changes in urban carbon emissions. However, as the extent of this effect is currently unclear, cities cannot easily formulate reasonable carbon reduction policies in terms of land use. Taking the city of Wuhan, China, as an example, this paper combines data on land use and carbon emissions from 1995 to 2019 and uses spatial analysis, curve estimation, and correlation evaluation to explore the direct and indirect effects of the UCL changes on carbon emissions. The results show that: (1) Between 1995 and 2019, the UCL area in Wuhan increased by 193.44%, and carbon emissions increased by 78.63%; moreover, both changes showed a gradually increasing spatial correlation, and the quantitative relationship could be better fitted with a composite function model; (2) The UCL change had mainly an indirect impact on carbon emissions via factors such as population and energy use intensity per unit of carbon emissions; (3) The maximum value of carbon emissions inside a unit area decreased during the study period, with an average annual decrease of about 2.02%. Therefore, the city of Wuhan can promote the achievement of its carbon emissions reduction targets by improving the existing land use policies, for example, by dividing the city into multiple functional zones.


Asunto(s)
Dióxido de Carbono , Carbono , Ciudades , Carbono/análisis , Análisis Espacial , China , Dióxido de Carbono/análisis
15.
Artículo en Inglés | MEDLINE | ID: mdl-35682308

RESUMEN

Heavy metal pollution in cultivated land poses a serious threat to environmental health and farmers' livelihoods. As the direct user of cultivated land, understanding farmers' adaptive behavior to heavy metal pollution, and its influencing factors, can provide insight and information relevant for decision-making, so as to better manage the hazards and risks of heavy metal pollution. We proposed a conceptual framework of "farmers' characteristics-perceptions-adaptive behaviors". Factor analysis and mediation effect analysis were used to explore the influence of characteristics and perceptions on adaptive behaviors. The data of 278 farmers in a typical mining area in Daye, China, show that local farmers perceive the hazards of heavy metal pollution, but their adaptive behaviors are hindered to a certain extent. The results of the mediation effect analysis show that perceptions of health impact, self-efficacy, and adaptive cost play a partial mediating role in the impact of characteristics on adaptive behaviors. In addition, the influence of the "factor of dependence on farmland" and the "factor of obstacles to action" on adaptive behavior have no significant relationship with perception levels. By comparing the influencing factors, we found that although farmers' perceptions have mediating effects between characteristics and adaptive behaviors, characteristics still play a decisive role in adaptive behaviors.


Asunto(s)
Agricultores , Metales Pesados , Adaptación Psicológica , Agricultura/métodos , China , Agricultores/psicología , Granjas , Humanos
16.
Physiol Behav ; 251: 113820, 2022 07 01.
Artículo en Inglés | MEDLINE | ID: mdl-35452628

RESUMEN

Alzheimer's disease-related cognition impairment is correlated with increased neuroinflammation. Studies show that physical exercises improve cognitive function and regulate neuroinflammation. However, no sufficient studies have been performed to directly observe the mechanism of exercise-related effects on microglia and neuroinflammation, in association with memory function under Alzheimer's disease. This study aims to explore the relationship of TREM2, microglia activation and neuroinflammation in the development of Alzheimer's disease, followed by investigating why physical exercises improve cognition in the Alzheimer's disease model by means of the adeno-associated virus (AAV) injection. We found that: 1) Recognition memory impairment in Aß-induced Alzheimer's disease model was associated with the reduction in TREM2 which induced microglial activation and neuroinflammation; 2) Exercise activated the TREM2 pathway, which was necessary for inhibiting microglial activation and neuroinflammation, leading to improved recognition memory in the Alzheimer's disease model. Together, the improvement of AD-associated recognition memory by exercises is associated with up-regulation of the TREM2 pathway which promotes the phenotypic conversion of microglia and decreases the level of neuroinflammation.


Asunto(s)
Enfermedad de Alzheimer , Enfermedad de Alzheimer/complicaciones , Enfermedad de Alzheimer/metabolismo , Animales , Modelos Animales de Enfermedad , Ejercicio Físico , Hipocampo/metabolismo , Humanos , Glicoproteínas de Membrana/metabolismo , Glicoproteínas de Membrana/farmacología , Ratones , Ratones Transgénicos , Microglía/metabolismo , Enfermedades Neuroinflamatorias , Receptores Inmunológicos/metabolismo
17.
Environ Sci Pollut Res Int ; 29(7): 10635-10648, 2022 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-34528190

RESUMEN

A clear understanding of the impacts of urban land expansion on ecosystem services is crucial for sustainable urban planning. Although various studies have shown that urban land expansion caused a degradation of ecosystem services, the relationship between the spatial variation of urban land expansion and ecosystem services still remains unclear. This study quantified the ecosystem services and urban land expansion indicators of Wuhan for 1990-2015 and analyzed the spatial and temporal variation characteristics of ecosystem service values (ESVs) and urban land expansion indicators. Using spatial autocorrelation analysis and linear regression, the quantitative and qualitative correlations between ecosystem services and urban land expansion indicators were explored. The total ESV of Wuhan decreased by 16.47%, representing a loss of 1636.19 million yuan. Areas with extremely low ESVs continuously expanded outward from the urban center. During 2010-2015, the urban land expansion area, intensity, damage weight, and distance peaked, which caused an enormous decrease of the total ESV. Negative correlations were found between urban land expansion and all ecosystem services; the correlation with food production was most significant, indicating that urban land expansion had the strongest impact on food production. The expansion area is the main factor causing the decline of each ecosystem service among urban land expansion indicators. This study presents the impact characteristics of urban land expansion on ecosystem services, and the results provide a reference for reasonable decision making in urban planning.


Asunto(s)
Conservación de los Recursos Naturales , Ecosistema , China , Ciudades , Análisis Espacial
18.
Sci Rep ; 12(1): 17522, 2022 10 20.
Artículo en Inglés | MEDLINE | ID: mdl-36266408

RESUMEN

Micro-expression is a kind of facial action that reflects the real emotional state of a person, and has high objectivity in emotion detection. Therefore, micro-expression recognition has become one of the research hotspots in the field of computer vision in recent years. Research with neural networks with convolutional structure is still one of the main methods of recognition. This method has the advantage of high operational efficiency and low computational complexity, but the disadvantage is its localization of feature extraction. In recent years, there are more and more plug-and-play self-attentive modules being used in convolutional neural networks to improve the ability of the model to extract global features of the samples. In this paper, we propose the ShuffleNet model combined with a miniature self-attentive module, which has only 1.53 million training parameters. First, the start frame and vertex frame of each sample will be taken out, and its TV-L1 optical flow features will be extracted. After that, the optical flow features are fed into the model for pre-training. Finally, the weights obtained from the pre-training are used as initialization weights for the model to train the complete micro-expression samples and classify them by the SVM classifier. To evaluate the effectiveness of the method, it was trained and tested on a composite dataset consisting of CASMEII, SMIC, and SAMM, and the model achieved competitive results compared to state-of-the-art methods through cross-validation of leave-one-out subjects.


Asunto(s)
Flujo Optico , Humanos , Redes Neurales de la Computación , Cara , Reconocimiento en Psicología , Emociones
19.
Front Neurorobot ; 16: 922761, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35845761

RESUMEN

As opposed to macro-expressions, micro-expressions are subtle and not easily detectable emotional expressions, often containing rich information about mental activities. The practical recognition of micro-expressions is essential in interrogation and healthcare. Neural networks are currently one of the most common approaches to micro-expression recognition. Still, neural networks often increase their complexity when improving accuracy, and overly large neural networks require extremely high hardware requirements for running equipment. In recent years, vision transformers based on self-attentive mechanisms have achieved accuracy in image recognition and classification that is no less than that of neural networks. Still, the drawback is that without the image-specific biases inherent to neural networks, the cost of improving accuracy is an exponential increase in the number of parameters. This approach describes training a facial expression feature extractor by transfer learning and then fine-tuning and optimizing the MobileViT model to perform the micro-expression recognition task. First, the CASME II, SAMM, and SMIC datasets are combined into a compound dataset, and macro-expression samples are extracted from the three macro-expression datasets. Each macro-expression sample and micro-expression sample are pre-processed identically to make them similar. Second, the macro-expression samples were used to train the MobileNetV2 block in MobileViT as a facial expression feature extractor and to save the weights when the accuracy was highest. Finally, some of the hyperparameters of the MobileViT model are determined by grid search and then fed into the micro-expression samples for training. The samples are classified using an SVM classifier. In the experiments, the proposed method obtained an accuracy of 84.27%, and the time to process individual samples was only 35.4 ms. Comparative experiments show that the proposed method is comparable to state-of-the-art methods in terms of accuracy while improving recognition efficiency.

20.
Artículo en Inglés | MEDLINE | ID: mdl-36612707

RESUMEN

The frequent occurrence of floods in urban areas caused by climate change challenges urban resilience. This research aims to construct an ecological security pattern (ESP) that is adaptive to floods to enhance urban resilience in the hope that it will help cities cope with floods better. In this research, the main urban area of Wuhan (WUH) represents the study area. The lakes were selected as the ecological sources and the Soil Conservation Service-Curve Number (SCS-CN) model was used to calculate the runoff volume corresponding to each land type and, based on this, assign resistance values to the land types; as such, the land type surface is referred to as the runoff resistance surface, and the runoff resistance surface is then modified by ecosystem service capabilities. The Minimum Cumulative Resistance (MCR) model was used to extract the connecting corridors between the sources. This research plan includes 18 ecological sources, 10 key ecological corridors, and 22 potential ecological corridors, with a total length of about 344.21 km. Finally, it provides a two-axis and three-core urban ecological resilience optimization strategy for decision makers and a new approach for controlling floods in urban areas from the perspective of ecological resilience.


Asunto(s)
Ecosistema , Inundaciones , Ciudades , Conservación de los Recursos Naturales , Suelo , China
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