Búsqueda | Biblioteca Virtual en Salud Fronteriza

1.

Conformational pathology of the serpins: themes, variations, and therapeutic strategies.

Gooptu, Bibek; Lomas, David A.

Annu Rev Biochem ; 78: 147-76, 2009.

Artículo en Inglés | MEDLINE | ID: mdl-19245336

2.

X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study.

Hayden, Lystra P; Hobbs, Brian D; Busch, Robert; Cho, Michael H; Liu, Ming; Lopes-Ramos, Camila M; Lomas, David A; Bakke, Per; Gulsvik, Amund; Silverman, Edwin K; Crapo, James D; Beaty, Terri H; Laird, Nan M; Lange, Christoph; DeMeo, Dawn L.

Respir Res ; 24(1): 38, 2023 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-36726148

3.

Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.

Pranke, Iwona Maria; Chevalier, Benoit; Premchandar, Aiswarya; Baatallah, Nesrine; Tomaszewski, Kamil F; Bitam, Sara; Tondelier, Danielle; Golec, Anita; Stolk, Jan; Lukacs, Gergely L; Hiemstra, Pieter S; Dadlez, Michal; Lomas, David A; Irving, James A; Delaunay-Moisan, Agnes; van Anken, Eelco; Hinzpeter, Alexandre; Sermet-Gaudelus, Isabelle; Edelman, Aleksander.

Cell Mol Life Sci ; 79(9): 503, 2022 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-36045259

4.

Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency.

Fromme, Malin; Schneider, Carolin V; Pereira, Vitor; Hamesch, Karim; Pons, Monica; Reichert, Matthias C; Benini, Federica; Ellis, Paul; H Thorhauge, Katrine; Mandorfer, Mattias; Burbaum, Barbara; Woditsch, Vivien; Chorostowska-Wynimko, Joanna; Verbeek, Jef; Nevens, Frederik; Genesca, Joan; Miravitlles, Marc; Nuñez, Alexa; Schaefer, Benedikt; Zoller, Heinz; Janciauskiene, Sabina; Abreu, Nélia; Jasmins, Luís; Gaspar, Rui; Liberal, Rodrigo; Macedo, Guilherme; Mahadeva, Ravi; Gomes, Catarina; Schneider, Kai Markus; Trauner, Michael; Krag, Aleksander; Gooptu, Bibek; Thorburn, Douglas; Marshall, Aileen; Hurst, John R; Lomas, David A; Lammert, Frank; Gaisa, Nadine T; Clark, Virginia; Griffiths, William; Trautwein, Christian; Turner, Alice M; McElvaney, Noel G; Strnad, Pavel.

Gut ; 71(2): 415-423, 2022 02.

Artículo en Inglés | MEDLINE | ID: mdl-33632708

5.

Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD.

Lipson, David A; Barnhart, Frank; Brealey, Noushin; Brooks, Jean; Criner, Gerard J; Day, Nicola C; Dransfield, Mark T; Halpin, David M G; Han, MeiLan K; Jones, C Elaine; Kilbride, Sally; Lange, Peter; Lomas, David A; Martinez, Fernando J; Singh, Dave; Tabberer, Maggie; Wise, Robert A; Pascoe, Steven J.

N Engl J Med ; 378(18): 1671-1680, 2018 May 03.

Artículo en Inglés | MEDLINE | ID: mdl-29668352

6.

Markers of disease activity in COPD: an 8-year mortality study in the ECLIPSE cohort.

Celli, Bartolome; Locantore, Nicholas; Yates, Julie C; Bakke, Per; Calverley, Peter M A; Crim, Courtney; Coxson, Harvey O; Lomas, David A; MacNee, William; Miller, Bruce E; Mullerova, Hana; Rennard, Stephen I; Silverman, Edwin K; Wouters, Emiel; Tal-Singer, Ruth; Agusti, Alvar; Vestbo, Jørgen.

Eur Respir J ; 57(3)2021 03.

Artículo en Inglés | MEDLINE | ID: mdl-33303557

7.

The development of highly potent and selective small molecule correctors of Z α₁-antitrypsin misfolding.

Liddle, John; Pearce, Andrew C; Arico-Muendel, Christopher; Belyanskaya, Svetlana; Brewster, Andrew; Brown, Murray; Chung, Chun-Wa; Denis, Alexis; Dodic, Nerina; Dossang, Anthony; Eddershaw, Peter; Klimaszewska, Diana; Haq, Imran; Holmes, Duncan S; Jagger, Alistair; Jakhria, Toral; Jigorel, Emilie; Lind, Ken; Messer, Jeff; Neu, Margaret; Olszewski, Allison; Ronzoni, Riccardo; Rowedder, James; Rüdiger, Martin; Skinner, Steve; Smith, Kathrine J; Trottet, Lionel; Uings, Iain; Zhu, Zhengrong; Irving, James A; Lomas, David A.

Bioorg Med Chem Lett ; 41: 127973, 2021 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-33753261

8.

The Effect of Inhaled Corticosteroid Withdrawal and Baseline Inhaled Treatment on Exacerbations in the IMPACT Study. A Randomized, Double-Blind, Multicenter Clinical Trial.

Han, MeiLan K; Criner, Gerard J; Dransfield, Mark T; Halpin, David M G; Jones, C Elaine; Kilbride, Sally; Lange, Peter; Lettis, Sally; Lipson, David A; Lomas, David A; Martin, Neil; Wise, Robert A; Singh, Dave; Martinez, Fernando J.

Am J Respir Crit Care Med ; 202(9): 1237-1243, 2020 11 01.

Artículo en Inglés | MEDLINE | ID: mdl-32584168

9.

Reduction in All-Cause Mortality with Fluticasone Furoate/Umeclidinium/Vilanterol in Patients with Chronic Obstructive Pulmonary Disease.

Lipson, David A; Crim, Courtney; Criner, Gerard J; Day, Nicola C; Dransfield, Mark T; Halpin, David M G; Han, MeiLan K; Jones, C Elaine; Kilbride, Sally; Lange, Peter; Lomas, David A; Lettis, Sally; Manchester, Pamela; Martin, Neil; Midwinter, Dawn; Morris, Andrea; Pascoe, Steven J; Singh, Dave; Wise, Robert A; Martinez, Fernando J.

Am J Respir Crit Care Med ; 201(12): 1508-1516, 2020 06 15.

Artículo en Inglés | MEDLINE | ID: mdl-32162970

10.

The Importance of N186 in the Alpha-1-Antitrypsin Shutter Region Is Revealed by the Novel Bologna Deficiency Variant.

Ronzoni, Riccardo; Ferrarotti, Ilaria; D'Acunto, Emanuela; Balderacchi, Alice M; Ottaviani, Stefania; Lomas, David A; Irving, James A; Miranda, Elena; Fra, Annamaria.

Int J Mol Sci ; 22(11)2021 May 26.

Artículo en Inglés | MEDLINE | ID: mdl-34073489

11.

Heteropolymerization of α-1-antitrypsin mutants in cell models mimicking heterozygosity.

Laffranchi, Mattia; Berardelli, Romina; Ronzoni, Riccardo; Lomas, David A; Fra, Annamaria.

Hum Mol Genet ; 27(10): 1785-1793, 2018 05 15.

Artículo en Inglés | MEDLINE | ID: mdl-29538751

12.

Whole exome sequencing analysis in severe chronic obstructive pulmonary disease.

Qiao, Dandi; Ameli, Asher; Prokopenko, Dmitry; Chen, Han; Kho, Alvin T; Parker, Margaret M; Morrow, Jarrett; Hobbs, Brian D; Liu, Yanhong; Beaty, Terri H; Crapo, James D; Barnes, Kathleen C; Nickerson, Deborah A; Bamshad, Michael; Hersh, Craig P; Lomas, David A; Agusti, Alvar; Make, Barry J; Calverley, Peter M A; Donner, Claudio F; Wouters, Emiel F; Vestbo, Jørgen; Paré, Peter D; Levy, Robert D; Rennard, Stephen I; Tal-Singer, Ruth; Spitz, Margaret R; Sharma, Amitabh; Ruczinski, Ingo; Lange, Christoph; Silverman, Edwin K; Cho, Michael H.

Hum Mol Genet ; 27(21): 3801-3812, 2018 11 01.

Artículo en Inglés | MEDLINE | ID: mdl-30060175

13.

The effect of exacerbation history on outcomes in the IMPACT trial.

Halpin, David M G; Dransfield, Mark T; Han, MeiLan K; Jones, C Elaine; Kilbride, Sally; Lange, Peter; Lipson, David A; Lomas, David A; Martinez, Fernando J; Pascoe, Steve; Singh, Dave; Wise, Robert; Criner, Gerard J.

Eur Respir J ; 55(5)2020 05.

Artículo en Inglés | MEDLINE | ID: mdl-32299860

14.

Single-inhaler triple therapy fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol and umeclidinium/vilanterol in patients with COPD: results on cardiovascular safety from the IMPACT trial.

Day, Nicola C; Kumar, Subramanya; Criner, Gerard; Dransfield, Mark; Halpin, David M G; Han, MeiLan K; Jones, C Elaine; Kaisermann, Morrys C; Kilbride, Sally; Lange, Peter; Lomas, David A; Martin, Neil; Martinez, Fernando J; Singh, Dave; Wise, Robert; Lipson, David A.

Respir Res ; 21(1): 139, 2020 Jun 05.

Artículo en Inglés | MEDLINE | ID: mdl-32503599

15.

Heme metabolism genes Downregulated in COPD Cachexia.

Wilson, Ava C; Kumar, Preeti L; Lee, Sool; Parker, Margaret M; Arora, Itika; Morrow, Jarrett D; Wouters, Emiel F M; Casaburi, Richard; Rennard, Stephen I; Lomas, David A; Agusti, Alvar; Tal-Singer, Ruth; Dransfield, Mark T; Wells, J Michael; Bhatt, Surya P; Washko, George; Thannickal, Victor J; Tiwari, Hemant K; Hersh, Craig P; Castaldi, Peter J; Silverman, Edwin K; McDonald, Merry-Lynn N.

Respir Res ; 21(1): 100, 2020 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-32354332

16.

It's more than low BMI: prevalence of cachexia and associated mortality in COPD.

McDonald, Merry-Lynn N; Wouters, Emiel F M; Rutten, Erica; Casaburi, Richard; Rennard, Stephen I; Lomas, David A; Bamman, Marcas; Celli, Bartolome; Agusti, Alvar; Tal-Singer, Ruth; Hersh, Craig P; Dransfield, Mark; Silverman, Edwin K.

Respir Res ; 20(1): 100, 2019 May 22.

Artículo en Inglés | MEDLINE | ID: mdl-31118043

17.

Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls.

Lutz, Sharon M; Frederiksen, Brittni; Begum, Ferdouse; McDonald, Merry-Lynn N; Cho, Michael H; Hobbs, Brian D; Parker, Margaret M; DeMeo, Dawn L; Hersh, Craig P; Ehringer, Marissa A; Young, Kendra; Jiang, Lai; Foreman, Marilyn G; Kinney, Greg L; Make, Barry J; Lomas, David A; Bakke, Per; Gulsvik, Amund; Crapo, James D; Silverman, Edwin K; Beaty, Terri H; Hokanson, John E.

Nicotine Tob Res ; 21(6): 714-722, 2019 05 21.

Artículo en Inglés | MEDLINE | ID: mdl-29767774

18.

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α₁-antitrypsin deficiency.

Segeritz, Charis-Patricia; Rashid, Sheikh Tamir; de Brito, Miguel Cardoso; Serra, Maria Paola; Ordonez, Adriana; Morell, Carola Maria; Kaserman, Joseph E; Madrigal, Pedro; Hannan, Nicholas R F; Gatto, Laurent; Tan, Lu; Wilson, Andrew A; Lilley, Kathryn; Marciniak, Stefan J; Gooptu, Bibek; Lomas, David A; Vallier, Ludovic.

J Hepatol ; 69(4): 851-860, 2018 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-29879455

19.

Alpha₁-Antitrypsin Deficiency.

Strnad, Pavel; McElvaney, Noel G; Lomas, David A.

N Engl J Med ; 382(15): 1443-1455, 2020 04 09.

Artículo en Inglés | MEDLINE | ID: mdl-32268028

20.

Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study.

Mohan, Divya; Forman, Julia R; Allinder, Matthew; McEniery, Carmel M; Bolton, Charlotte Emma; Cockcroft, John R; MacNee, William; Fuld, Jonathan; Marchong, Mellone; Gale, Nichola Sian; Fisk, Marie; Nagarajan, Sridevi; Cheriyan, Joseph; Lomas, David A; Calverley, Peter M A; Miller, Bruce E; Tal-Singer, Ruth; Wilkinson, Ian B; Polkey, Michael I.

Thorax ; 73(12): 1182-1185, 2018 12.

Artículo en Inglés | MEDLINE | ID: mdl-29618495

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