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1.
Neuroradiology ; 65(10): 1527-1534, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-37289228

RESUMEN

PURPOSE: Reporting the clinical outcomes, patient satisfaction, and complications following an imaging-guided percutaneous screw fixation in the treatment of sacroiliac joint dysfunction and evaluating the safety and effectiveness of this method. METHODS: We performed a retrospective study on a prospectively gathered cohort of patients with physiotherapy-resistant pain due to sacroiliac joint incompetence that underwent percutaneous screw fixation, between 2016 and 2022 in our center. A minimum of two screws were used in all patients to obtain fixation of the sacroiliac joint, using percutaneous screw insertion under CT guidance, coupled with a C-arm fluoroscopy unit. RESULTS: The mean visual analog scale significantly improved at 6 months of follow-up (p < 0.05). One hundred percent of the patients reported significant improvement in pain scores at the final follow-up. None of our patients experienced intraoperative or postoperative complications. CONCLUSION: The use of percutaneous sacroiliac screws provides a safe and effective technique for the treatment of sacroiliac joint dysfunction in patients with chronic resistant pain.


Asunto(s)
Fijación Interna de Fracturas , Articulación Sacroiliaca , Humanos , Fijación Interna de Fracturas/efectos adversos , Fijación Interna de Fracturas/métodos , Estudios Retrospectivos , Articulación Sacroiliaca/diagnóstico por imagen , Articulación Sacroiliaca/cirugía , Resultado del Tratamiento , Tomografía Computarizada por Rayos X , Dolor
2.
Semin Musculoskelet Radiol ; 27(5): 561-565, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-37816364

RESUMEN

Our goal was to determine if "Nomenclature 2.0," the classification of lumbar disk pathology consensus, should be updated. We conducted a social media and e-mail-based survey on preferences regarding the use of classification on magnetic resonance spine reporting. Members of the European Society of Neuroradiology, European Society of Musculoskeletal Radiology, American Society of Neuroradiology, and American Society of Spine Radiology received a 15-question online survey between February and March 2022. A total of 600 responses were received from 63 countries. The largest number of responses came from Italy and the United States. We found that 71.28% of respondents used Nomenclature 2.0, Classification of Lumbar Disk Pathology. But classification on stenosis is used less often: 53.94% and 60% of respondents do not use any classification of spinal canal stenosis and foraminal stenosis, respectively. When queried about which part of Nomenclature needs improving, most respondents asked for a Structured Reporting Template (SRT), even though 58.85% of respondents do not currently use any template and 54% routinely use a clinical information questionnaire. These results highlight the importance of an updated Nomenclature 3.0 version that integrates the classifications of lumbar disk disease and spinal canal and foraminal stenosis. Further attention should also be directed toward developing a robust endorsed SRT.


Asunto(s)
Degeneración del Disco Intervertebral , Estenosis Espinal , Humanos , Estados Unidos , Constricción Patológica/patología , Vértebras Lumbares/diagnóstico por imagen , Imagen por Resonancia Magnética , Estenosis Espinal/diagnóstico por imagen , Encuestas y Cuestionarios
3.
AJNR Am J Neuroradiol ; 18(4): 773-5, 1997 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-9127048

RESUMEN

We describe an unusual labyrinthine malformation in a case of Goldenhar syndrome studied with CT and steady-state MR imaging. A single posterosuperior semicircular canal was found with no common crus formation. The malformation could not be attributed to any embryologic development. Nosologic considerations are discussed.


Asunto(s)
Síndrome de Goldenhar/diagnóstico , Canales Semicirculares/anomalías , Anomalías Múltiples , Niño , Conducto Auditivo Externo/anomalías , Osículos del Oído/anomalías , Oído Interno/anomalías , Síndrome de Goldenhar/diagnóstico por imagen , Pérdida Auditiva Bilateral/diagnóstico , Pérdida Auditiva Bilateral/diagnóstico por imagen , Pérdida Auditiva Conductiva/diagnóstico , Pérdida Auditiva Conductiva/diagnóstico por imagen , Humanos , Imagen por Resonancia Magnética , Masculino , Tomografía Computarizada por Rayos X , Vestíbulo del Laberinto/anomalías
4.
AJNR Am J Neuroradiol ; 20(9): 1750-1, 1999 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-10543654

RESUMEN

We describe a case of the "tilted-disk" syndrome in a patient with a bitemporal field depression (a pseudohemianopia). CT and MR imaging showed thinning and prolapse of the nasal sectors of the posterior walls of the globes and flattening of the temporal portion of the globes.


Asunto(s)
Coloboma/diagnóstico , Fondo de Ojo , Hemianopsia/diagnóstico , Imagen por Resonancia Magnética , Disco Óptico/anomalías , Tomografía Computarizada por Rayos X , Adulto , Coloboma/patología , Diagnóstico Diferencial , Femenino , Humanos , Disco Óptico/patología , Nervio Óptico/anomalías , Nervio Óptico/patología , Síndrome
5.
AJNR Am J Neuroradiol ; 21(6): 1145-50, 2000.
Artículo en Inglés | MEDLINE | ID: mdl-10871030

RESUMEN

BACKGROUND AND PURPOSE: Several techniques have been used to image the nasolacrimal system, providing functional (dacryoscintigraphy) or morphologic (dacryocystography, CT dacryocystography [CTD]) information. Using gadopentetate dimeglumine-diluted solution injected into the lacrimal canaliculus or instilled into the conjunctival sac, we compared the sensitivity of MR dacryocystography (MRD) with that of CTD. METHODS: Eleven healthy volunteers and 25 patients affected by primary epiphora (21 patients) or postsurgical recurrent epiphora (four patients) underwent MRD after the topical administration of contrast media or cannulation of the lacrimal canaliculus. The MR imaging findings were compared with irrigation and CTD data. All patients underwent surgical treatment (dacryocystorhinostomy), which served as a standard of reference for confirming the MRD findings. RESULTS: The topical administration of contrast-enhanced saline solution and the injection of contrast-enhanced saline solution after cannulation were always well tolerated. In healthy volunteers, outflow of contrast media was always revealed by MRD. Eight (32%) of 25 patients with epiphora had stenosis proximal to the lacrimal sac revealed by MRD, whereas 17 (68%) of 25 showed a dilated lacrimal sac and nasolacrimal duct stenosis, as confirmed by surgical findings. The findings of MRD after the topical administration of contrast medium and MRD after cannulation of the lacrimal canaliculus were comparable with irrigation or CTD data for all patients except one. CONCLUSION: In patients with epiphora, MR imaging performed after the topical administration of diluted contrast material can reveal stenosis of the lacrimal apparatus and can be added to the standard orbital imaging protocol when lacrimal system involvement is suspected.


Asunto(s)
Imagen por Resonancia Magnética/normas , Conducto Nasolagrimal/diagnóstico por imagen , Conducto Nasolagrimal/patología , Tomografía Computarizada por Rayos X/normas , Constricción Patológica , Medios de Contraste , Dacriocistorrinostomía , Femenino , Gadolinio DTPA , Humanos , Enfermedades del Aparato Lagrimal/diagnóstico , Enfermedades del Aparato Lagrimal/cirugía , Masculino , Valores de Referencia , Sensibilidad y Especificidad
6.
Eur J Neurol ; 5(1): 89-94, 1998 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-10210817

RESUMEN

Somatosensory evoked potentials (SEPs) and brainstem auditory evoked potentials (BAEPs) were recorded in 10 patients with myotonic dystrophy and in 20 sex and age-matched healthy controls. In all patients a brain MRI examination was also performed. In our results, the significantly longer absolute peak latencies of the SEPs and the abnormal increasing of the later components of the BAEPs suggest an involvement of the afferent sensory and central auditory pathways. Brain MRI showed white matter hyperintense lesions (WMHL) in eight patients (80%). No correlations were found between individual abnormal electrophysiological parameters or severity of WMHL and age, age at onset, disease duration or muscular impairment. The total number (SEP + BAEP) of electrophysiological abnormalities significantly correlated with muscular impairment (p < 0.05) and MRI changes (p < 0.005), suggesting a strict pathogenetic linkage between muscular and nervous system alterations in this disease.

7.
Clin Imaging ; 21(5): 311-8, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-9316748

RESUMEN

Perfusion MRI (magnetic resonance imaging) of the pituitary gland was performed in 20 healthy volunteers and 63 patients with various lesions involving the pituitary gland. All patients underwent sequential contrast-enhanced MRI using spoiled gradient recalled sequences with high temporal resolution (7 seconds). Four pituitary areas (pituitary stalk, posterior lobe, postero-superior, and antero-inferior adenohypophysis) were tested with a selected region of interest. Maximal contrast percentual variation was calculated. The timing of enhancement in normal patients matched perfectly with normal pituitary vascularization. Abnormal timing in pathological condition was investigated.


Asunto(s)
Adenoma/irrigación sanguínea , Hormona Adrenocorticotrópica/metabolismo , Imagen por Resonancia Magnética/métodos , Hipófisis/irrigación sanguínea , Neoplasias Hipofisarias/irrigación sanguínea , Prolactinoma/irrigación sanguínea , Adenoma/diagnóstico , Medios de Contraste , Diagnóstico Diferencial , Femenino , Gadolinio DTPA , Humanos , Procesamiento de Imagen Asistido por Computador , Masculino , Enfermedades de la Hipófisis/diagnóstico , Neoplasias Hipofisarias/diagnóstico , Prolactinoma/diagnóstico , Valores de Referencia , Flujo Sanguíneo Regional/fisiología
8.
Electromyogr Clin Neurophysiol ; 39(5): 305-13, 1999.
Artículo en Inglés | MEDLINE | ID: mdl-10422001

RESUMEN

We performed clinical, radiological (MRI) and neurophysiological (NCV, SEPs, and BAEPs) investigations in 36 unselected patients affected by Systemic Lupus Erythematosus (SLE). Fifteen patients (42%) presented clear neurological events and were considered as definite neuropsychiatric lupus (NPLE); 21 (58%) presented minor subjective complaints or no neurological problems referable to SLE and were considered as no-NPLE. Twenty-three patients (64%) showed neurophysiological abnormalities: 21 (58%) presented central abnormal neurophysiological measurements (including SEP and BAEP values), while 17 (47%) has slowed peripheral nerve conduction. Twenty-six out of 36 patients executed brain MRI examination. High intensity spots (HIS) in deep or subcortical white matter were the most common abnormalities and were present in 19 of the 26 patients (73%). We found that the incidence of neurophysiological and radiological abnormalities did not significantly differ in neurologically symptomatic and asymptomatic patients. Central nervous system impairment evidenced by abnormal N13-20 interpeak intervals (p = 0.05) and HIS (p = 0.01) findings was significantly associated with the presence of cutaneous vasculitis; while peripheral nerve involvement was significantly more frequent in patients with renal failure (p = 0.006).


Asunto(s)
Potenciales Evocados/fisiología , Lupus Eritematoso Sistémico/fisiopatología , Imagen por Resonancia Magnética , Lesión Renal Aguda/fisiopatología , Adulto , Encefalopatías/diagnóstico , Encefalopatías/fisiopatología , Corteza Cerebral/patología , Distribución de Chi-Cuadrado , Potenciales Evocados Auditivos del Tronco Encefálico/fisiología , Potenciales Evocados Somatosensoriales/fisiología , Femenino , Humanos , Lupus Eritematoso Sistémico/diagnóstico , Masculino , Conducción Nerviosa/fisiología , Neurofisiología , Enfermedades del Sistema Nervioso Periférico/fisiopatología , Tiempo de Reacción , Enfermedades Cutáneas Vasculares/fisiopatología , Vasculitis/fisiopatología
9.
Acta Otorhinolaryngol Ital ; 18(4 Suppl 59): 80-6, 1998 Aug.
Artículo en Italiano | MEDLINE | ID: mdl-10205939

RESUMEN

Magnetic resonance contrast imaging using gadolinium-DTPA and performing new high resolution sequences (Fast Spin-Echo, Spoiled Gradient-Echo) or angiographic sequences (Magnetic Resonance Angiography) allows an excellent visualization of the inner ear and the cerebellopontine angle to be obtained. Furthermore, using sequences obtained with the "steady-state" technique (Gradient Recalled At Steady-State-GRASS, Constructive Interference at Steady-State-CISS), a good analysis of the structures of the membranous labyrinth can be achieved. Based on these diagnostic techniques, we have studied the morphological features of the membranous labyrinth in patients with progressive sensorineural hearing loss due to inner ear malformations, labyrinthitis, neuritis of VII and VIII cranial nerves, degenerative entities such as otosclerosis and Ménière's disease, neoplasms of the cerebellopontine angle, of the inner ear and of the middle ear (glomus tumours, acoustic neuromas, meningiomas, epidermoid tumours, arachnoid cysts and malignant neoplasms).


Asunto(s)
Oído Interno/anomalías , Pérdida Auditiva Sensorineural/etiología , Progresión de la Enfermedad , Enfermedades del Oído/complicaciones , Enfermedades del Oído/diagnóstico , Neoplasias del Oído/complicaciones , Neoplasias del Oído/diagnóstico , Pérdida Auditiva Sensorineural/diagnóstico , Humanos , Imagen por Resonancia Magnética
10.
Rev Laryngol Otol Rhinol (Bord) ; 116(2): 91-3, 1995.
Artículo en Inglés | MEDLINE | ID: mdl-7569382

RESUMEN

A group of patients complaining of facial nerve palsy (Bell's palsy) were evaluated with MRI using a 0.5 unit and high resolution T1-weighted images, in order to evaluate the efficacy of Gd-DTPA enhancement in depicting the degree of nerve damage: MRI examination was performed within 24 hours to two weeks after the onset of palsy. The authors describe the results obtained from the analysis of 11 cases of Bell's palsy, discussing the prognostic and clinical significance.


Asunto(s)
Nervio Facial/patología , Parálisis Facial/patología , Imagen por Resonancia Magnética , Adolescente , Adulto , Femenino , Humanos , Aumento de la Imagen , Masculino , Persona de Mediana Edad
11.
Neuroradiol J ; 24(6): 919-23, 2011 Dec 30.
Artículo en Inglés | MEDLINE | ID: mdl-24059898

RESUMEN

We performed CT-guided posterior interbody fusion (PIF) with pedicle screw fixation and distraction to treat degenerative lumbar L4-L5 spondylolisthesis with severe left sciatica. The patient was suffering from L4 nerve root compression related to neural foramina stenosis. The dedicated tools to perform a CT-guided percutaneous PIF technique are described. The procedure was easy to apply with a total surgical time of 90 minutes. The neural foramina were investigated by CT scan reconstruction on sagittal plane demonstrating marked widening after PIF application. The left leg pain completely disappeared in two weeks and the patient remained painless at the three month follow-up control. To our knowledge, there are no other papers on CT-guided PIF procedure in the literature.

12.
Minerva Pediatr ; 57(2): 111-6, 2005 Apr.
Artículo en Italiano | MEDLINE | ID: mdl-15986003

RESUMEN

Cerebral venous thrombosis is quite rare in newborn infants, but probably its incidence is not well evaluated because clinical signs and cerebral echocardiography are not specific. We report the case of an newborn infant with massive cerebral venous thrombosis associated with heart malformation: supramitral ring and partial anomalous pulmonary venous connection in the superior vena cava.


Asunto(s)
Cardiopatías Congénitas/diagnóstico , Venas Pulmonares/anomalías , Trombosis de los Senos Intracraneales/etiología , Adolescente , Niño , Preescolar , Electrocardiografía , Cardiopatías Congénitas/complicaciones , Humanos , Lactante , Imagen por Resonancia Magnética , Masculino , Insuficiencia de la Válvula Mitral/etiología , Trombosis de los Senos Intracraneales/diagnóstico
13.
Neurol Sci ; 21(5): 329-31, 2000 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-11286047

RESUMEN

Lipoma is a very rare tumour at the cerebellopontine angle. We report a case of incomplete hemifacial spasm, associated with a lipoma involving and compressing both facial and acoustic nerves at their origin in the brainstem. The patient was treated with medical therapy (botulinum toxin A) and surgery. We present a review of the last ten years of the literature, with particular regard to management.


Asunto(s)
Neoplasias Cerebelosas/complicaciones , Neoplasias Cerebelosas/terapia , Ángulo Pontocerebeloso/cirugía , Espasmo Hemifacial/etiología , Lipoma/complicaciones , Lipoma/terapia , Toxinas Botulínicas Tipo A/uso terapéutico , Neoplasias Cerebelosas/cirugía , Femenino , Humanos , Lipoma/cirugía , Imagen por Resonancia Magnética , Persona de Mediana Edad , Fármacos Neuromusculares/uso terapéutico , Resultado del Tratamiento
14.
Minerva Pediatr ; 49(3): 101-7, 1997 Mar.
Artículo en Italiano | MEDLINE | ID: mdl-9198729

RESUMEN

Discitis is an inflammatory disease of the intervertebral disc which has usually a benign evolution in childhood. It often recognizes an infectious etiology. Still discussed however is the possibility of a primitive discal involvement (not secondary to a vertebral inflammation) or of a non infectious etiology and the subsequent more correct diagnostic-therapeutic procedures. We report a case of a girl with discitis diagnosed early and treated with antibiotics and orthopedic corset, whose follow-up shows a benign evolution. We underline the importance of modern neuroradiological imaging: in particular, MR plays a major role in the inflammatory diseases of the column, both in diagnosis and in follow-up. MR scans of the involved disc allow frequent controls without radiogenic risks and with a good resolution because of the multiplanarity typical of the method.


Asunto(s)
Discitis/diagnóstico , Antiinfecciosos/administración & dosificación , Antiinfecciosos/uso terapéutico , Cefotaxima/administración & dosificación , Cefotaxima/análogos & derivados , Cefotaxima/uso terapéutico , Cefalosporinas/administración & dosificación , Cefalosporinas/uso terapéutico , Niño , Ciprofloxacina/administración & dosificación , Ciprofloxacina/uso terapéutico , Discitis/tratamiento farmacológico , Discitis/patología , Femenino , Humanos , Región Lumbosacra/patología , Imagen por Resonancia Magnética , Teicoplanina/administración & dosificación , Teicoplanina/uso terapéutico
15.
Eur Radiol ; 10(8): 1338-41, 2000.
Artículo en Inglés | MEDLINE | ID: mdl-10939504

RESUMEN

Detection and characterization of intraorbital foreign bodies (IFB) is fundamental in acute trauma setting, preventing inflammatory sequelae or complications related to IFB movements when a MRI study is planned. Papers concerning plain film and CT sensibility in IFB detection show controversial results. For this reason we investigated plain film, CT and MRI sensibility in the evaluation of IFB. For an in vitro model, specimens of dry and fresh wood, glass, iron, plastic and graphite were immersed in animal lard and in a 0.9% sodium chloride plus 3.5 g/dl human serum albumin solution. Specimens of different size and nature where also implanted into enucleated pig eyes. Air bubbles were introduced also. Plain film, CT and MRI investigation were performed. Plain films underestimated intraocular IFB as plastic, fresh or dry wooden IFB were not demonstrated. The CT study was always able to depict and differentiate IFB according to the attenuation values. Severe artefacts prevented demonstration of iron, glass and graphite IFB on MRI, whereas plastic or wooden IFB were always detected. Despite radiographs have been suggested as a prerequisite for MR imaging, because our results showed plain film to underestimate radiolucent IFB, we suggest CT as the modality of choice when IFB has to be ruled out.


Asunto(s)
Cuerpos Extraños en el Ojo/diagnóstico , Imagen por Resonancia Magnética , Órbita , Tomografía Computarizada por Rayos X , Animales , Ojo/patología , Lesiones Oculares Penetrantes/diagnóstico , Humanos , Órbita/patología , Sensibilidad y Especificidad , Porcinos
16.
Neuroradiology ; 35(8): 612-3, 1993.
Artículo en Inglés | MEDLINE | ID: mdl-8278044

RESUMEN

A case of traumatic orbital encephalocele following a "blow-in" fracture is presented. Computed tomography (CT) and magnetic resonance imaging (MRI) findings are shown. Although CT was useful for identifying the orbital roof fracture, bone fragments and soft tissue abnormalities, MRI was more sensitive to brain herniation and an intraorbital haematoma.


Asunto(s)
Encefalocele/etiología , Fracturas Orbitales/diagnóstico , Adulto , Encefalocele/diagnóstico , Humanos , Imagen por Resonancia Magnética , Masculino , Fracturas Orbitales/complicaciones , Tomografía Computarizada por Rayos X
17.
Radiol Med ; 88(3): 183-9, 1994 Sep.
Artículo en Italiano | MEDLINE | ID: mdl-7938720

RESUMEN

The pterygopalatine fossa (PPF) is a narrow, bone lined space containing many major cranial nerves and vessels connecting it to the middle and infratemporal cranial fossa, the oral, nasal and orbital cavities and the rhinopharynx. The internal maxillary artery, the second branch of the V cranial nerve and the sphenopalatine ganglion are the main structures which are found in the PPF. Because of its strategic site, the PPF can be involved in many pathologic conditions originating from the nasal fossa, the orbit, the paranasal sinuses or the rhinopharynx roof. Severe craniofacial trauma can involve the pterygopalatine area too. Consequently, the detailed knowledge of PPF anatomy and the use of the current imaging modalities are necessary in the study of pterygopalatine lesions. We examined a group of 7 patients who underwent CT and MRI for diseases not involving the pterygopalatine area. CT consisted of axial and coronal contiguous 1-mm scans, with post-processing sagittal and 3D reconstructions. MRI was performed with a middle-field unit, using a head coil and high-resolution 3-mm T1- and T2-weighted spin- and fast-spin-echo scans. 3D SPGR pulse sequences were also performed. We found HRCT scans and post-processing 3D studies to be particularly indicated in bone structure analysis. SPGR, spin- and fast-spin-echo MR sequences allowed us to obtained reliable images of the main nervous and vascular structures found in the PPF. Finally, we believe combined CT and MRI to be the method of choice in the study of PPF anatomy and in the assessment of diseases involving the PPF area.


Asunto(s)
Imagen por Resonancia Magnética , Maxilar/anatomía & histología , Maxilar/diagnóstico por imagen , Órbita/anatomía & histología , Órbita/diagnóstico por imagen , Hueso Esfenoides/anatomía & histología , Hueso Esfenoides/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Femenino , Humanos , Imagen por Resonancia Magnética/instrumentación , Imagen por Resonancia Magnética/métodos , Masculino , Valores de Referencia , Tomografía Computarizada por Rayos X/métodos
18.
Neuroradiology ; 35(5): 359-61, 1993.
Artículo en Inglés | MEDLINE | ID: mdl-8327112

RESUMEN

Thirteen patients who underwent surgery for retinal detachment and injection of intraocular tamponade media (silicone oil, fluorosilicone oil, or perfluorocarbon liquid) underwent magnetic resonance imaging (MRI), using spin-echo T1- and T2-weighted images. The ophthalmic tamponade media showed different signal intensity, according to their chemical structure. Unlike ophthalmoscopy or ultrasonography, MRI showed no oil-related artefact, making possible recognition of recurrent retinal detachment.


Asunto(s)
Imagen por Resonancia Magnética , Complicaciones Posoperatorias/diagnóstico , Retina/patología , Desprendimiento de Retina/cirugía , Aceites de Silicona/administración & dosificación , Humanos , Recurrencia , Cuerpo Vítreo/patología
19.
Neuroradiology ; 38(7): 669-74, 1996 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-8912326

RESUMEN

We report our experience with MRI of the normal and pathological inner ear with fast spin-echo and modified gradient recalled at steady state sequences. Although earlier studies on temporal bone MRI were discouraging, improvements in MR technology combined with the use of paramagnetic contrast media can make MRI a useful diagnostic tool for the assessment of inner ear pathology. Conventional spin-echo imaging seems not to be the modality of choice because of the relatively thick slices and the long acquisition times.


Asunto(s)
Oído Interno/patología , Procesamiento de Imagen Asistido por Computador , Enfermedades del Laberinto/diagnóstico , Imagen por Resonancia Magnética , Enfermedad Crónica , Femenino , Fístula/diagnóstico , Humanos , Masculino , Síndrome de Noonan/diagnóstico , Otitis Media/diagnóstico , Valores de Referencia , Canales Semicirculares/patología , Hueso Temporal/patología
20.
J Endocrinol Invest ; 22(10): 740-6, 1999 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-10614522

RESUMEN

The purpose of the present study was to assess the presence and the time-course of contrast-enhancement in the pituitary gland and pituitary stalk of 24 patients with isolated growth hormone (GH) deficiency and multiple pituitary hormone deficiency. The patients were evaluated clinically (auxological measurements), endocrinologically (spontaneous GH secretion and GH stimulation tests) and with conventional MRI scans. In addition, fast-framing dynamic magnetic resonance imaging (MRI) with Gd-DTPA enhancement was used to quantitate the time course of contrast enhancement within the neurohypophysis, pituitary stalk, postero-superior adenohypophysis and antero-inferior adenohypophysis. In 3 patients without evidence of abnormalities at normal conventional MRI scans (normal anterior lobe and pituitary stalk, normal posterior lobe) and a high response to the GRF provocation test, sequential time-resolved Gd-enhanced MRI demonstrates reduced contrast enhancement in the pituitary stalk. These findings are consistent with impairment in stalk vasculature, presumably located at the level of the portal venous system, and could play a role in the pathogenesis of pituitary hormonal deficiency.


Asunto(s)
Trastornos del Crecimiento/diagnóstico , Hormona de Crecimiento Humana/deficiencia , Imagen por Resonancia Magnética/métodos , Niño , Femenino , Humanos , Masculino , Hipófisis/patología
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