1.
Bioorg Med Chem Lett
; 15(21): 4752-6, 2005 Nov 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16125385
RESUMEN
The activated Factor VII/tissue factor complex (FVIIa/TF) plays a key role in the formation of blood clots. Inhibition of this complex may lead to new antithrombotic drugs. An X-ray crystal structure of a fluoropyridine-based FVIIa/TF inhibitor bound in the active site of the enzyme complex suggested that incorporation of substitution at the 5-position of the hydroxybenzoic acid side chain could lead to the formation of more potent inhibitors through interactions with the S1'/S2' pocket.