1.
Org Biomol Chem
; 22(11): 2175-2181, 2024 Mar 13.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38259235
RESUMEN
Herein, we report a KIO3-catalyzed oxidative coupling of thiols to their corresponding disulfides in water, in a short time and at ambient temperature. The reaction has a broad scope and exhibits good functional group tolerance, resulting in the desired products in excellent yields. This approach allows the reuse of the reaction system in multiple cycles and scale-up. Furthermore, the current protocol demonstrates compatibility for in situ generation of disulfides and post application in C(sp2)-H bond sulfenylation.