Detalles de la búsqueda
1.
Discovery of novel oridonin sulfamide derivatives as potent NLRP3 inhibitors by a visible-light photocatalysis-enabled peripheral editing.
Bioorg Med Chem Lett
; 99: 129621, 2024 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38244941
2.
Synthesis and antibacterial evaluation of novel psoralen derivatives against methicillin-resistant Staphylococcus aureus (MRSA).
Chem Biodivers
; : e202302048, 2024 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38263380
3.
Pharmacokinetic, Tissue Distribution, Metabolite, and Toxicity Evaluation of the Matrine Derivative, (6aS, 10S, 11aR, 11bR, 11cS)-10-Methylaminododecahydro-3a, 7a-Diaza-benzo (de) Anthracene-8-thione.
Molecules
; 29(2)2024 Jan 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38257210
4.
Discovery of Novel 3,11-Bispeptide Ester Arenobufagin Derivatives with Potential in Vivo Antitumor Activity and Reduced Cardiotoxicity.
Chem Biodivers
; 20(2): e202200911, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36627123
5.
Discovery and optimization of betulinic acid derivatives as novel potent CD73 inhibitors.
Bioorg Med Chem
; 59: 116672, 2022 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35217359
6.
Discovery of natural product ellagic acid as a potent CD73 and CD39 dual inhibitor.
Bioorg Med Chem Lett
; 34: 127758, 2021 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33359608
7.
Design, Synthesis and Biological Activity of (20S,21S)-7-Cyclohexyl-21-fluorocamptothecin Carbamates as Potential Antitumor Agents.
Chem Biodivers
; 17(7): e2000068, 2020 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-32342605
8.
Chalcone: A Privileged Structure in Medicinal Chemistry.
Chem Rev
; 117(12): 7762-7810, 2017 Jun 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28488435
9.
An Indole-Chalcone Inhibits Multidrug-Resistant Cancer Cell Growth by Targeting Microtubules.
Mol Pharm
; 15(9): 3892-3900, 2018 09 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30048137
10.
Novel non-trimethoxylphenyl piperlongumine derivatives selectively kill cancer cells.
Bioorg Med Chem Lett
; 27(11): 2308-2312, 2017 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28434764
11.
Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran-oxindole derivatives as potent p53-MDM2 inhibitors.
Bioorg Med Chem
; 25(20): 5268-5277, 2017 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28797774
12.
Enantioselective organocatalytic Michael addition of isorhodanines to α,ß-unsaturated aldehydes.
Org Biomol Chem
; 14(16): 3926-33, 2016 Apr 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-27044054
13.
State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.
Chem Soc Rev
; 44(22): 8238-59, 2015 Nov 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-26248294
14.
Correction: State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.
Chem Soc Rev
; 44(22): 8375, 2015 Nov 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-26308471
15.
Scaffold hopping of sampangine: discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans.
Bioorg Med Chem Lett
; 24(17): 4090-4, 2014 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25115626
16.
Discovery of 1-arylpyrrolidone derivatives as potent p53-MDM2 inhibitors based on molecule fusing strategy.
Bioorg Med Chem Lett
; 24(12): 2648-50, 2014 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24813735
17.
Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors.
Int J Mol Sci
; 15(9): 15741-53, 2014 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-25198897
18.
Synthesis and biological assays of 9-(acylamino) homocamptothecins as DNA topoisomerase I inhibitors.
Chem Biodivers
; 10(10): 1804-15, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24130024
19.
Fragment-Based Discovery of Azocyclic Alkyl Naphthalenesulfonamides as Keap1-Nrf2 Inhibitors for Acute Lung Injury Treatment.
J Med Chem
; 66(12): 8267-8280, 2023 06 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-37257073
20.
Novel chlorin e6-based conjugates of tyrosine kinase inhibitors: Synthesis and photobiological evaluation as potent photosensitizers for photodynamic therapy.
Eur J Med Chem
; 261: 115787, 2023 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37690263