RESUMEN
Seven new sesquiterpene lactone glycosides (1-7) were isolated from the H2O-soluble fraction from the MeOH extract of the roots of Ferula varia. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations of compounds 1 and 2 were determined by modified Mosher's method.
Asunto(s)
Ferula/química , Glicósidos/química , Lactonas/química , Sesquiterpenos/química , Glicósidos/aislamiento & purificación , Espectroscopía de Resonancia Magnética , Metanol/química , Conformación Molecular , Raíces de Plantas/química , Agua/químicaRESUMEN
Monoterpene glycosides (1-5, and 7), together with 14 known compounds, were isolated from the methanol extract of the roots of Paeonia hybrida. These compounds included a paeoniflorin-related glycoside with a hybrid structure of paeoniflorin and paeonovicinoside (1), a monoterpene glucoside biogenetically related to lactiflorin (2), a paeoniflorin-related monoterpene (3), arbiflorin-related monoterpenes (4 and 5), and a tymol-related monoterpene glycoside (7). Their structures were elucidated by extensive spectroscopic examinations.
Asunto(s)
Glicósidos/aislamiento & purificación , Paeonia/química , Terpenos/aislamiento & purificación , Benzoatos/química , Hidrocarburos Aromáticos con Puentes/química , Glucósidos/química , Glicósidos/química , Espectroscopía de Resonancia Magnética , Medicina Tradicional China , Metanol/química , Estructura Molecular , Monoterpenos , Raíces de Plantas/química , Terpenos/químicaRESUMEN
Two eudesmanes, two abietanes, two podocarpanes and other nine known compounds were isolated from the dried fruits of Juniperus polycarpus var. seravschanica. Their structures were established on the basis of analysis of spectroscopic evidence. Some of the isolated terpenoids showed antimalarial activity.
Asunto(s)
Juniperus/química , Terpenos/análisis , Abietanos/análisis , Abietanos/química , Abietanos/farmacología , Animales , Antimaláricos/análisis , Antimaláricos/química , Antimaláricos/farmacología , Diterpenos/análisis , Diterpenos/química , Diterpenos/farmacología , Frutas/química , Espectroscopía de Resonancia Magnética , Estructura Molecular , Extractos Vegetales/análisis , Extractos Vegetales/química , Extractos Vegetales/farmacología , Plasmodium falciparum/efectos de los fármacos , Plasmodium falciparum/crecimiento & desarrollo , Sesquiterpenos/análisis , Sesquiterpenos/química , Sesquiterpenos/farmacología , Sesquiterpenos de Eudesmano/análisis , Sesquiterpenos de Eudesmano/química , Sesquiterpenos de Eudesmano/farmacología , Terpenos/química , Terpenos/farmacologíaRESUMEN
[structure: see text] A structurally unique hydrophobic compound, biyouyanagin A, was isolated from the MeOH extract of the leaves of Hypericum chinense L. var. salicifolium. The structure of biyouyanagin A was elucidated on the basis of spectroscopic evidence. Biyouyanagin A showed a significant activity against HIV and inhibited cytokine production.
Asunto(s)
Fármacos Anti-VIH/aislamiento & purificación , Fármacos Anti-VIH/farmacología , Citocinas/antagonistas & inhibidores , Hypericum/química , Plantas Medicinales/química , Sesquiterpenos/aislamiento & purificación , Sesquiterpenos/farmacología , Fármacos Anti-VIH/química , Citocinas/biosíntesis , Interleucina-10/antagonistas & inhibidores , Interleucina-10/biosíntesis , Interleucina-12/antagonistas & inhibidores , Interleucina-12/biosíntesis , Lipopolisacáridos/farmacología , Estructura Molecular , Hojas de la Planta , Sesquiterpenos/química , Compuestos de Espiro , Factor de Necrosis Tumoral alfa/antagonistas & inhibidores , Factor de Necrosis Tumoral alfa/biosíntesisRESUMEN
As part of our chemical studies on the medical plants in Uzbekistan aimed at searching for new drug leads, we have examined the aerial parts of Mediasia macrophylla. This has resulted in the isolation of four new glucosides, together with 30 known compounds. The structures of new compounds were elucidated as (1'S)-(4-hydroxyphenyl) ethane-1',2'-diol 2'-O-ß-glucopyranoside (1), 3-(4'-methoxyphenyl)-propanol 1-O-ß-glucopyranoside (2), 2-methoxy-3-hydroxy-5-(E)-propenyl-phenol 1-O-ß-glucopyranoside (3), 1-O-angeloyl-ß-glucopyranose (4), on the basis of spectral analysis.
Asunto(s)
Apiaceae/química , Glucósidos/química , Componentes Aéreos de las Plantas/química , Espectroscopía de Resonancia Magnética , Estructura Molecular , UzbekistánRESUMEN
Polyacetylenic glucosides (1-5) were isolated from the MeOH extract of Mediasia macrophylla, and their structures were established by spectroscopic analyses. Compounds 2-4 were the first examples of C(10)-polyacetylenic glucosides found in the family Umbelliferae, while compound 1 was a unique polyacetylenic glucoside possessing an alpha-pyrone moiety.
Asunto(s)
Alquinos/aislamiento & purificación , Apiaceae/química , Glucósidos/aislamiento & purificación , Extractos Vegetales/química , Pironas/química , Alquinos/química , Glucósidos/química , Estructura Molecular , Componentes Aéreos de las PlantasRESUMEN
A new codonopsine-related alkaloid and 13 known compounds were isolated from the aerial parts of Codonopsis clematidea (Campanulaceae). The structure of the new compound was elucidated by two-dimensional nuclear magnetic resonance and other spectral examinations.
Asunto(s)
Alcaloides/aislamiento & purificación , Anisoles/aislamiento & purificación , Codonopsis/química , Componentes Aéreos de las Plantas/química , Pirrolidinas/aislamiento & purificación , Alcaloides/química , Anisoles/química , Cromatografía Líquida de Alta Presión , Espectroscopía de Resonancia Magnética , Extractos Vegetales/química , Extractos Vegetales/aislamiento & purificación , Pirrolidinas/químicaRESUMEN
The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones (1-6) and five known sesquiterpenes (7-11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1-11 were evaluated against selected human cancer cell lines. Compound 4 showed significant selective cytotoxicity against multidrug-resistant cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine.
Asunto(s)
Antineoplásicos Fitogénicos/aislamiento & purificación , Antineoplásicos Fitogénicos/farmacología , Ferula/química , Lactonas/aislamiento & purificación , Lactonas/farmacología , Plantas Medicinales/química , Sesquiterpenos/aislamiento & purificación , Sesquiterpenos/farmacología , Antineoplásicos Fitogénicos/química , Colchicina/análisis , Colchicina/farmacocinética , Resistencia a Múltiples Medicamentos/efectos de los fármacos , Resistencia a Antineoplásicos/efectos de los fármacos , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Células KB , Lactonas/química , Estructura Molecular , Raíces de Plantas/química , Sesquiterpenos/química , UzbekistánRESUMEN
Two new stilbene derivatives, (E)-resveratrol 3-(6' '-galloyl)-O-beta-D-glucopyranoside (1) and (E)-resveratrol 3-(4' '-acetyl)-O-beta-D-xylopyranoside (2), and five known stilbene derivatives (3-7) were isolated from the dried aerial parts of Calligonum leucocladum. Their structures were established on the basis of spectroscopic evidence. Compound 1 showed antioxidant activity and a restorative effect of the inhibition of oxacillin to oxacillin/methicillin-resistant Staphylococcus aureus.