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Front Immunol ; 12: 606963, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34054794

RESUMEN

Toxoplasma gondii infection can trigger autoreactivity by different mechanisms. In the case of ocular toxoplasmosis, disruption of the blood-retinal barrier may cause exposure of confined retinal antigens such as recoverin. Besides, cross-reactivity can be induced by molecular mimicry of parasite antigens like HSP70, which shares 76% identity with the human ortholog. Autoreactivity can be a determining factor of clinical manifestations in the eye and in the central nervous system. We performed a prospective observational study to determine the presence of autoantibodies against recoverin and HSP70 by indirect ELISA in the serum of 65 patients with ocular, neuro-ophthalmic and congenital cerebral toxoplasmosis. We found systemic autoantibodies against recoverin and HSP70 in 33.8% and 15.6% of individuals, respectively. The presence of autoantibodies in cases of OT may be related to the severity of clinical manifestations, while in cases with CNS involvement they may have a protective role. Unexpectedly, anti-recoverin antibodies were found in patients with cerebral involvement, without ocular toxoplasmosis; therefore, we analyzed and proved cross-reactivity between recoverin and a brain antigen, hippocalcin, so the immunological phenomenon occurring in one immune-privileged organ (e.g. the central nervous system) could affect the environment of another (egg. the eye).


Asunto(s)
Autoanticuerpos/inmunología , Autoantígenos/inmunología , Interacciones Huésped-Parásitos/inmunología , Toxoplasmosis Cerebral/inmunología , Toxoplasmosis Congénita/inmunología , Toxoplasmosis Ocular/inmunología , Adolescente , Adulto , Secuencia de Aminoácidos , Antígenos de Protozoos/inmunología , Niño , Preescolar , Reacciones Cruzadas/inmunología , Femenino , Proteínas HSP70 de Choque Térmico/química , Proteínas HSP70 de Choque Térmico/inmunología , Hipocalcina/química , Hipocalcina/inmunología , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Recoverina/química , Recoverina/inmunología , Toxoplasma/inmunología , Toxoplasmosis Cerebral/diagnóstico , Toxoplasmosis Cerebral/parasitología , Toxoplasmosis Congénita/diagnóstico , Toxoplasmosis Congénita/parasitología , Toxoplasmosis Ocular/diagnóstico , Toxoplasmosis Ocular/parasitología , Adulto Joven
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