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1.
J Surg Res ; 273: 211-217, 2022 05.
Artículo en Inglés | MEDLINE | ID: mdl-35093837

RESUMEN

INTRODUCTION: When appropriately used, helicopter emergency medical services (HEMSs) allow for timely delivery of severely injured patients to definitive care. Inappropriate utilization of HEMSs results in increased cost to the patient and trauma system. The purpose of this study was to review current HEMS criteria in the central Gulf Coast region and evaluate for potential areas of triage refinement and cost savings. We hypothesized that a significant number of patients received potentially unwarranted HEMS transport. METHODS: A retrospective cohort study of all patients with trauma arriving to a level I trauma center by helicopter over 28 mo was performed; 381 patients with trauma and with HEMS transport from the scene were included. Data were collected from prehospital sources, as well as hospital chart review for each patient. The primary outcome was the rate of unwarranted HEMS transport. RESULTS: A total of 381 adult patients with trauma transported by the HEMS were analyzed, of which 34% were deemed potentially nonwarranted transports. The significant factors correlating with warranted HEMS transport included age, multiple long bone fractures, penetrating mechanism, and vehicle ejection. Insurance demographics did not correlate to transport modality. Many of these patients were transported from a location within the same county or the county adjacent to the trauma center. When comparing patients transported by ground and HEMSs from the same scene, no time savings were identified. Unwarranted transports at the trauma center represented an estimated health care expenditure of over $3 million. CONCLUSIONS: HEMSs may be overused in the central Gulf Coast region, creating the risk for a substantial resource and financial burden to the trauma system. Further collaboration is needed to establish HEMS triage criteria, that is, more appropriate use of resources.


Asunto(s)
Ambulancias Aéreas , Servicios Médicos de Urgencia , Heridas y Lesiones , Adulto , Aeronaves , Servicios Médicos de Urgencia/métodos , Gastos en Salud , Hemorragia , Humanos , Estudios Retrospectivos , Centros Traumatológicos , Heridas y Lesiones/terapia
2.
Am J Emerg Med ; 34(2): 235-9, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26597495

RESUMEN

OBJECTIVES: Acute elbow injuries are common in the acute care setting. A previous study observed that limited active range of motion (ROM) was highly sensitive for radiographic injuries after blunt trauma. Our aim was to validate these findings in patients ≥5 years old with an acute (<24 hours) nonpenetrating elbow injury. METHODS: This prospective study included a convenience sample of patients undergoing plain radiographs of an injured elbow in 3 emergency departments. Before imaging, treating clinicians completed a standardized data collection sheet including mechanism of injury and 4-way ROM findings (full extension, flexion to 90°, full pronation and supination). Radiographic interpretation by a staff radiologist was used to ascertain the presence of fracture or joint effusion. RESULTS: The median age of the 251 patients was 24 years. Ninety-two patients (36.7%) had active 4-way ROM, and 159 patients (63.3%) demonstrated limited ROM. Negative radiographs were present in 152 patients (60.6%), whereas 99 patients (39.4%) had abnormal radiographs: 75 with explicit fractures and 24 with only joint effusions. The 4-way ROM elbow test had a sensitivity of 0.99 (95% confidence interval [CI], 0.94-1.00), specificity of 0.60 (95% CI, 0.52-0.68), positive predictive value of 0.62 (95% CI, 0.54-0.69), and negative predictive value of 0.99 (95% CI, 0.94-1.00). CONCLUSIONS: Active 4-way ROM test is 99% sensitive for all radiographic injures following blunt elbow trauma and 100% sensitive for injuries requiring surgical intervention. Caution should be used in relying on this test in the pediatric population until it is validated in a larger cohort.


Asunto(s)
Lesiones de Codo , Articulación del Codo/diagnóstico por imagen , Rango del Movimiento Articular/fisiología , Heridas no Penetrantes/diagnóstico por imagen , Heridas no Penetrantes/fisiopatología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Servicio de Urgencia en Hospital , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios Prospectivos , Radiografía , Sensibilidad y Especificidad
3.
Am J Emerg Med ; 30(9): 1667-73, 2012 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22424991

RESUMEN

OBJECTIVE: The objective of this study is to determine if metformin use affects the prevalence and prognostic value of hyperlactatemia to predict mortality in septic adult emergency department (ED) patients. METHODS: This is a single-center retrospective cohort study. Emergency department providers identified study subjects; data were collected from the medical record. PATIENTS: Adult ED patients with suspected infection and 2 or more systemic inflammatory response syndrome criteria were included. The outcome was 28-day mortality. The primary risk variable was serum lactate (<2.0, 2.0-3.9, ≥ 4.0 mmol/L) categorized by metformin use; covariates: demographics, Predisposition, Infection, Response, Organ Dysfunction score and metformin use contraindications. SETTING: The study was conducted at an urban teaching hospital; February 1, 2007 to October 31, 2008. RESULTS: A total of 1947 ED patients were enrolled; 192 (10%) were taking metformin; 305 (16%) died within 28 days. Metformin users had higher median lactate levels than nonusers (2.2 mmol/L [interquartile range, 1.6-3.2] vs 1.9 mmol/L [interquartile range, 1.3-2.8]) and a higher, although nonsignificant, prevalence of hyperlactatemia (lactate ≥ 4.0 mmol/L) (17% vs 13%) (P = .17). In multivariate analysis (reference group nonmetformin users, lactate <2.0 mmol/L), hyperlactatemia was associated with an increased adjusted 28-day mortality risk among nonmetformin users (odds ratio [OR], 3.18; P < .01) but not among metformin users (OR, 0.54; P = .33). In addition, nonmetformin users had a higher adjusted mortality risk than metformin users (OR, 2.49; P < .01). These differences remained significant when only diabetic patients were analyzed. CONCLUSIONS: In this study of adult ED patients with suspected sepsis, metformin users had slightly higher median lactate levels and prevalence of hyperlactatemia. However, hyperlactatemia did not predict an increased mortality risk in patients taking metformin.


Asunto(s)
Hipoglucemiantes/farmacología , Lactatos/sangre , Metformina/farmacología , Sepsis/diagnóstico , Anciano , Servicio de Urgencia en Hospital , Femenino , Humanos , Modelos Logísticos , Masculino , Valor Predictivo de las Pruebas , Pronóstico , Estudios Retrospectivos , Sepsis/sangre , Sepsis/mortalidad
4.
J Emerg Med ; 42(6): e125-8, 2012 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-19703743

RESUMEN

BACKGROUND: Emergency airway management is a diverse discipline, often utilizing advanced equipment with video technology to enable the intubator to visualize a patient's vocal cords that would be difficult or impossible to see with routine direct laryngoscopy. The GlideScope® Cobalt (Saturn Biomedical Systems, Inc., Burnaby, BC, Canada) is one type of video laryngoscope with disposable plastic GVL® Stat blades (Saturn Biomedical Systems) that can improve glottic view over direct laryngoscopy. It also benefits from rapid turnaround time and few infection control issues due to its disposable blade. OBJECTIVE: To report what we believe to be the first GlideScope® blade failure to be reported in the medical literature. The circumstances surrounding the blade failure may raise awareness of GVL® Stat usage in obese patients with limited mouth opening. CASE REPORT: During a standard emergency intubation, insertion of the GVL® Stat into the patient's mouth resulted in breakage of the distal segment of the blade. The patient was severely obese and had limited mouth opening, which required the blade to be inserted obliquely, rather than in the midline, into the patient's mouth. As the handle was repositioned back to midline, the distal segment of the blade broke off. No excessive force was used during blade repositioning when breakage occurred. CONCLUSION: Twisting forces on the distal flat segment of the GVL® Stat may have caused its failure. Because this was only a single occurrence of breakage, it is not clear if design issues or atypical insertion of the blade was responsible for breakage. Care must be exercised when midline insertion is not possible, which can occur in obese patients with limited mouth opening.


Asunto(s)
Falla de Equipo , Intubación Intratraqueal/instrumentación , Laringoscopios/normas , Equipos Desechables/normas , Femenino , Humanos , Persona de Mediana Edad , Obesidad/complicaciones , Inconsciencia/terapia
5.
Alcohol Clin Exp Res ; 35(11): 1960-5, 2011 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22044287

RESUMEN

BACKGROUND: S-adenosyl-L-methionine (SAM) is the methyl donor for all methylation reactions and regulates the synthesis of glutathione, the main cellular antioxidant. Previous experimental studies suggested that SAM may benefit patients with established alcoholic liver diseases (ALDs). The aim of this study was to determine the efficacy of SAM in treatment for ALD in a 24-week trial. The primary endpoints were changes in serum aminotransferase levels and liver histopathology scores, and the secondary endpoints were changes in serum levels of methionine metabolites. METHODS: We randomized 37 patients with ALD to receive 1.2 g of SAM by mouth or placebo daily. Subjects were required to remain abstinent from alcohol drinking. A baseline liver biopsy was performed in 24 subjects, and a posttreatment liver biopsy was performed in 14 subjects. RESULTS: Fasting serum SAM levels were increased over timed intervals in the SAM treatment group. The entire cohort showed an overall improvement of AST, ALT, and bilirubin levels after 24 weeks of treatment, but there were no differences between the treatment groups in any clinical or biochemical parameters nor any intra- or intergroup differences or changes in liver histopathology scores for steatosis, inflammation, fibrosis, and Mallory-Denk hyaline bodies. CONCLUSIONS: Whereas abstinence improved liver function, 24 weeks of therapy with SAM was no more effective than placebo in the treatment for ALD.


Asunto(s)
Hepatopatías Alcohólicas/tratamiento farmacológico , Hepatopatías Alcohólicas/metabolismo , S-Adenosilmetionina/uso terapéutico , Adulto , Anciano , Alanina Transaminasa/sangre , Aspartato Aminotransferasas/sangre , Biopsia , Método Doble Ciego , Femenino , Humanos , Hígado/metabolismo , Hígado/patología , Masculino , Metionina/metabolismo , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del Tratamiento
7.
J Hepatol ; 53(3): 551-7, 2010 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-20561703

RESUMEN

BACKGROUND & AIMS: Although abnormal hepatic methionine metabolism plays a central role in the pathogenesis of experimental alcoholic liver disease (ALD), its relationship to the risk and severity of clinical ALD is not known. The aim of this clinical study was to determine the relationship between serum levels of methionine metabolites in chronic alcoholics and the risk and pathological severity of ALD. METHODS: Serum levels of liver function biochemical markers, vitamin B6, vitamin B12, folate, homocysteine, methionine, S-adenosylmethionine, S-adenosylhomocysteine, cystathionine, cysteine, alpha-aminobutyrate, glycine, serine, and dimethylglycine were measured in 40 ALD patients, of whom 24 had liver biopsies, 26 were active drinkers without liver disease, and 28 were healthy subjects. RESULTS: Serum homocysteine was elevated in all alcoholics, whereas ALD patients had low vitamin B6 with elevated cystathionine and decreased alpha-aminobutyrate/cystathionine ratios, consistent with decreased activity of vitamin B6 dependent cystathionase. The alpha-aminobutyrate/cystathionine ratio predicted the presence of ALD, while cystathionine correlated with the stage of fibrosis in all ALD patients. CONCLUSIONS: The predictive role of the alpha-aminobutyrate/cystathionine ratio for the presence of ALD and the correlation between cystathionine serum levels with the severity of fibrosis point to the importance of the homocysteine transsulfuration pathway in ALD and may have important diagnostic and therapeutic implications.


Asunto(s)
Homocisteína/sangre , Hepatopatías Alcohólicas/sangre , Adulto , Anciano , Alcoholismo/sangre , Aminobutiratos/sangre , Biomarcadores/sangre , Estudios de Casos y Controles , Cistationina/sangre , Progresión de la Enfermedad , Femenino , Homocisteína/química , Humanos , Hígado/patología , Cirrosis Hepática Alcohólica/sangre , Cirrosis Hepática Alcohólica/patología , Hepatopatías Alcohólicas/patología , Masculino , Metionina/sangre , Persona de Mediana Edad , Azufre/química , Adulto Joven
8.
J Emerg Med ; 39(3): 282-90, 2010 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-18687564

RESUMEN

The objective of this study was to measure the prevalence of chest pain centers, and describe the associated protocols most commonly used to rapidly risk-stratify patients in these units. This study is a survey conducted from May to July 2003 via direct mail. A questionnaire was mailed to 4653 hospitals in the United States. A total of 462 questionnaires were returned, representing a return rate of approximately 10%. This survey revealed that approximately 64% of all hospitals have a protocol for the evaluations of patients who present with chest pain, and 38% of all hospitals reported a designated area for the evaluation of these patients. The majority of hospitals responding to this survey have a protocol for the evaluation of patients presenting with chest pain, however, the presence of a chest pain unit exists in only 38% of all responding institutions.


Asunto(s)
Dolor en el Pecho/diagnóstico , Servicio de Urgencia en Hospital , Pautas de la Práctica en Medicina/estadística & datos numéricos , Protocolos Clínicos , Femenino , Humanos , Masculino , Medición de Riesgo , Encuestas y Cuestionarios , Estados Unidos
9.
Air Med J ; 29(6): 266-70, 2010.
Artículo en Inglés | MEDLINE | ID: mdl-21055635

RESUMEN

This article is the 16(th) in a multipart series designed to assist readers, particularly novices, in the area of clinical research. This article is focused on the process of developing a new research project. It provides tools to help those involved in beginning their own research projects.


Asunto(s)
Lista de Verificación , Desarrollo de Programa/métodos , Proyectos de Investigación
10.
Am J Emerg Med ; 26(7): 779-82, 2008 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-18774042

RESUMEN

OBJECTIVE: Previous studies indicate that an inability to fully extend the elbow after elbow trauma is indicative of fracture. We hypothesized that maintenance of active range of motion (ROM) of the elbow in flexion, extension, pronation, and supination after elbow trauma is very specific for the absence of fracture or effusion, and limitation of ROM is sensitive for fracture or effusion. METHODS: This was a prospective observational study with convenience sampling of a carefully selected patient population. This would allow certain types of patients to be excluded from the study. Patients with elbow injury receiving radiographs and meeting enrollment criteria were enrolled between June 2006 and March 2007 at 4 emergency departments in the local region. Demographics, active ROM, and presence of point tenderness at the olecranon, epicondyles, and radial head were recorded by enrolling clinicians. All enrolled patients received standard elbow radiographs. Radiographs were reviewed by blinded radiologists for the presence of fracture and effusion. Sensitivity, specificity, and 95% confidence intervals (CIs) of examination findings were calculated. RESULTS: One hundred thirteen patients were enrolled. Limitation of active ROM was 100% (95% CI, 0.93-1.00) sensitive for fracture or effusion. Preservation of active ROM was 97% (95% CI, 0.89-1.00) specific for the absence of fracture. Point tenderness was also highly sensitive but not specific. CONCLUSION: Individuals with preservation of active ROM after acute elbow trauma have a very low risk of associated fracture and may not require radiographic studies.


Asunto(s)
Lesiones de Codo , Fracturas Óseas/diagnóstico , Rango del Movimiento Articular , Adulto , Niño , Codo/diagnóstico por imagen , Servicio de Urgencia en Hospital , Femenino , Fracturas Óseas/clasificación , Fracturas Óseas/diagnóstico por imagen , Humanos , Masculino , Valor Predictivo de las Pruebas , Estudios Prospectivos , Radiografía
11.
J Emerg Med ; 35(1): 15-21, 2008 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-18226871

RESUMEN

Physician reporting of lapses of consciousness (LOC) to the Department of Motor Vehicles is a controversial topic in medicine. The objective of this study was to describe current LOC reporting practices by emergency physicians (EPs) in a state with mandatory reporting requirements (California). A questionnaire describing 14 different clinical scenarios involving LOC was distributed to a diverse sample of California EPs. Clinical scenarios included new seizure, hypoglycemia, atrial fibrillation/rapid heart rate, cerebrovascular accident, micturation syncope, vasovagal syncope, hepatic encephalopathy, alcohol intoxication, closed head injury, hyperosmolar coma, methamphetamine psychosis, dementia, hyperventilation syndrome, and hypercalcemia. Emergency physicians were asked how often they would report these LOC-related conditions to the state. Simple summary statistics were calculated. The response rate was 207/340 (61%) of the forms distributed. The average number of years in Emergency Medicine practice among respondents was 12 (range 1-35), and 57% were Emergency Medicine trained. Of the 14 scenarios, only one (new-onset seizure) was reported frequently by EPs (89% reported "nearly always" or "most of the time"). The remaining 13 scenarios were rarely reported (mean of 86% for "occasionally" or "never"). Although reporting of LOC, from any cause, is mandatory in California, only new-onset seizures are frequently reported by California EPs.


Asunto(s)
Conducción de Automóvil/legislación & jurisprudencia , Medicina de Emergencia/estadística & datos numéricos , Notificación Obligatoria , Rol del Médico , Inconsciencia/etiología , Adolescente , Adulto , Anciano , California , Femenino , Humanos , Masculino , Persona de Mediana Edad , Encuestas y Cuestionarios
12.
J Emerg Med ; 28(2): 147-52, 2005 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-15707808

RESUMEN

To describe the prevalence and types of distracting injuries associated with vertebral injuries at all levels of the spine in blunt trauma patients. A prospective cohort study was conducted at an urban Level I trauma center. All patients undergoing radiographic evaluation of the cervical, thoracic, or lumbar vertebrae after blunt trauma were enrolled. Patients had a data collection form completed by the treating physician before radiographic imaging and were evaluated for the following upon initial presentation: tenderness to the cervical, thoracic, or lumbar spine, distracting injuries, altered mental status, alcohol or drug intoxication, or neurological deficits. Patients with distracting injuries as the sole documented indication for vertebral radiographs were reviewed for the types of injuries present. A total of 4698 patients were enrolled in the study. There were 336 (7.2%) patients who had distracting injuries as the sole documented indication for obtaining radiographic studies of the vertebrae. Eight (2.4%, 95% CI 1.0-4.6%) of the 336 patients had 14 acute vertebral injuries including compression fractures (5), transverse process fractures (7), spinous process fracture (1), and cervical spine rotatory subluxation (1). There were 13 thoracolumbar injuries and one cervical spine injury. Distracting injuries in the eight patients with acute vertebral injuries included 13 bony fractures. Distracting injuries in those patients without vertebral injuries included bony fractures (333), lacerations (63), soft tissue contusions (62), head injuries (15), bony dislocations (12), abrasions (11), visceral injuries (8), dental injuries (5), burns (3), ligamentous injuries (3), amputation (1), and compartment syndrome (1). In conclusion, in patients with distracting injuries, bony fractures of any type were important for identifying patients with vertebral injuries. Other types of distracting injuries did not contribute to the sensitivity of the clinical screening criteria in the detection of patients with vertebral injuries.


Asunto(s)
Traumatismo Múltiple/epidemiología , Traumatismos Vertebrales/epidemiología , Heridas no Penetrantes/epidemiología , Adolescente , Adulto , Distribución por Edad , Anciano , Anciano de 80 o más Años , California/epidemiología , Niño , Preescolar , Comorbilidad , Contusiones/epidemiología , Femenino , Fracturas Óseas/epidemiología , Humanos , Lactante , Laceraciones/epidemiología , Masculino , Persona de Mediana Edad , Dolor/epidemiología , Prevalencia , Estudios Prospectivos
13.
JAMA Intern Med ; 175(11): 1792-801, 2015 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-26348734

RESUMEN

IMPORTANCE: Clostridium difficile is a major cause of health care-associated infection, but disagreement between diagnostic tests is an ongoing barrier to clinical decision making and public health reporting. Molecular tests are increasingly used to diagnose C difficile infection (CDI), but many molecular test-positive patients lack toxins that historically defined disease, making it unclear if they need treatment. OBJECTIVE: To determine the natural history and need for treatment of patients who are toxin immunoassay negative and polymerase chain reaction (PCR) positive (Tox-/PCR+) for CDI. DESIGN, SETTING, AND PARTICIPANTS: Prospective observational cohort study at a single academic medical center among 1416 hospitalized adults tested for C difficile toxins 72 hours or longer after admission between December 1, 2010, and October 20, 2012. The analysis was conducted in stages with revisions from April 27, 2013, to January 13, 2015. MAIN OUTCOMES AND MEASURES: Patients undergoing C difficile testing were grouped by US Food and Drug Administration-approved toxin and PCR tests as Tox+/PCR+, Tox-/PCR+, or Tox-/PCR-. Toxin results were reported clinically. Polymerase chain reaction results were not reported. The main study outcomes were duration of diarrhea during up to 14 days of treatment, rate of CDI-related complications (ie, colectomy, megacolon, or intensive care unit care) and CDI-related death within 30 days. RESULTS: Twenty-one percent (293 of 1416) of hospitalized adults tested for C difficile were positive by PCR, but 44.7% (131 of 293) had toxins detected by the clinical toxin test. At baseline, Tox-/PCR+ patients had lower C difficile bacterial load and less antibiotic exposure, fecal inflammation, and diarrhea than Tox+/PCR+ patients (P < .001 for all). The median duration of diarrhea was shorter in Tox-/PCR+ patients (2 days; interquartile range, 1-4 days) than in Tox+/PCR+ patients (3 days; interquartile range, 1-6 days) (P = .003) and was similar to that in Tox-/PCR- patients (2 days; interquartile range, 1-3 days), despite minimal empirical treatment of Tox-/PCR+ patients. No CDI-related complications occurred in Tox-/PCR+ patients vs 10 complications in Tox+/PCR+ patients (0% vs 7.6%, P < .001). One Tox-/PCR+ patient had recurrent CDI as a contributing factor to death within 30 days vs 11 CDI-related deaths in Tox+/PCR+ patients (0.6% vs 8.4%, P = .001). CONCLUSIONS AND RELEVANCE: Among hospitalized adults with suspected CDI, virtually all CDI-related complications and deaths occurred in patients with positive toxin immunoassay test results. Patients with a positive molecular test result and a negative toxin immunoassay test result had outcomes that were comparable to patients without C difficile by either method. Exclusive reliance on molecular tests for CDI diagnosis without tests for toxins or host response is likely to result in overdiagnosis, overtreatment, and increased health care costs.


Asunto(s)
Toxinas Bacterianas/análisis , Clostridioides difficile/aislamiento & purificación , Infecciones por Clostridium , Infección Hospitalaria , Uso Excesivo de los Servicios de Salud , Reacción en Cadena de la Polimerasa/estadística & datos numéricos , Anciano , Antibacterianos/uso terapéutico , Infecciones por Clostridium/diagnóstico , Infecciones por Clostridium/tratamiento farmacológico , Infecciones por Clostridium/microbiología , Estudios de Cohortes , Infección Hospitalaria/diagnóstico , Infección Hospitalaria/tratamiento farmacológico , Infección Hospitalaria/microbiología , Femenino , Hospitalización/estadística & datos numéricos , Humanos , Masculino , Uso Excesivo de los Servicios de Salud/prevención & control , Uso Excesivo de los Servicios de Salud/estadística & datos numéricos , Persona de Mediana Edad , Estudios Prospectivos , Estados Unidos
14.
Rev Cardiovasc Med ; 3 Suppl 4: S35-40, 2002.
Artículo en Inglés | MEDLINE | ID: mdl-12439429

RESUMEN

Over the past decade, there have been a number of studies of the use of noninvasive ventilation (NIV) in patients with respiratory failure, including that associated with acute congestive heart failure (CHF). Many of these studies have focused on using NIV in an effort to avoid endotracheal intubation, with its associated complications and costs. Most studies have been small, retrospective, and not well focused on the CHF population. As a result, clinical use of NIV in a setting of severe CHF has been controversial and recommendations mixed; however, most studies support a beneficial role for NIV in patients with acute cardiogenic pulmonary edema. Its use is associated with lower endotracheal intubation rates and possibly lower mortality. This article describes two NIV modalities, continuous positive airway pressure (CPAP) and bi-level positive airway pressure (BLPAP), and compares their efficacy. Though BLPAP has theoretical advantages over CPAP, there are questions regarding its safety in a setting of CHF. The key to success in using NIV to treat severe CHF is proper patient selection, close patient monitoring, proper application of the technology, and objective therapeutic goals. When used appropriately, NIV can be a useful adjunct in the treatment of a subset of patients with acute CHF at risk for endotracheal intubation.


Asunto(s)
Insuficiencia Cardíaca/terapia , Terapia por Inhalación de Oxígeno , Respiración Artificial , Tratamiento de Urgencia , Humanos , Ensayos Clínicos Controlados Aleatorios como Asunto , Respiración Artificial/métodos
15.
Ann Emerg Med ; 43(4): 435-46, 2004 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-15039684

RESUMEN

STUDY OBJECTIVE: We determine the efficacy of prophylactic phenytoin in preventing early posttraumatic seizures in children with moderate to severe blunt head injury. METHODS: Children younger than 16 years and experiencing moderate to severe blunt head injury were randomized to receive phenytoin or placebo within 60 minutes of presentation at 3 pediatric trauma centers. The primary endpoint was posttraumatic seizures within 48 hours; secondary endpoints were survival and neurologic outcome 30 days after injury. A Bayesian decision-theoretic clinical trial design was used to determine the probability of remaining posttraumatic seizure free for each treatment group. RESULTS: One hundred two patients were enrolled, with a median age of 6.1 years. Sixty-eight percent were boys. The 2 treatment groups were well matched. During the 48-hour observation period, 3 (7%) of 46 patients given phenytoin and 3 (5%) of 56 patients given placebo experienced a posttraumatic seizure. There were no significant differences between the treatment groups in survival or neurologic outcome after 30 days. According to these results, the probability that phenytoin has the originally hypothesized effect of reducing the rate of early posttraumatic seizures by 12.5% is 0.0053. The probability that phenytoin has any prophylactic efficacy is 0.383. The median effect size in this trial was -0.015 (seizure rate increased by 1.5% in the phenytoin group), 95% probability interval -0.127 to 0.091 (12.7% higher rate of posttraumatic seizures to a 9.1% lower rate of posttraumatic seizures with phenytoin). CONCLUSION: The rate of early posttraumatic seizures in children may be much lower than previously reported. Phenytoin did not substantially reduce that rate.


Asunto(s)
Anticonvulsivantes/uso terapéutico , Traumatismos Cerrados de la Cabeza/tratamiento farmacológico , Fenitoína/uso terapéutico , Convulsiones/prevención & control , Adolescente , Barbitúricos/uso terapéutico , Teorema de Bayes , Benzodiazepinas/uso terapéutico , Niño , Preescolar , Método Doble Ciego , Femenino , Escala de Coma de Glasgow , Traumatismos Cerrados de la Cabeza/complicaciones , Hospitales Urbanos , Humanos , Lactante , Masculino , Consentimiento Paterno , Tamaño de la Muestra , Resultado del Tratamiento
16.
Acad Emerg Med ; 9(11): 1227-35, 2002 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-12414476

RESUMEN

"Patient Care" is the first listed core competency of the six new core competencies recently formulated by the Accreditation Council for Graduate Medical Education (ACGME) and, arguably, the most important. To assist emergency medicine (EM) program directors in incorporating and assessing this competency, the Council of Emergency Medicine Residency Directors (CORD-EM) held a consensus conference in March 2002. Definitions of this competency were generated that are specific for the training of practitioners in EM. These built upon the ACGME base definition, but include elements unique to or critically important in EM. In addition, all of the ACGME assessment tools were examined and prioritized for use in assessing the competency of EM residents in the area of patient care. Suggestions for an implementation process are also described.


Asunto(s)
Competencia Clínica , Medicina de Emergencia/educación , Medicina de Emergencia/normas , Internado y Residencia , Conferencias de Consenso como Asunto , Curriculum , Evaluación Educacional , Humanos , Internado y Residencia/normas , Satisfacción del Paciente , Simulación de Paciente
17.
Acad Emerg Med ; 9(6): 561-6, 2002 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-12045068

RESUMEN

OBJECTIVE: To validate the predictive value of the Canadian clinical probability model for acute venous thrombosis, which, to the best of the authors' knowledge, has not been done in emergency department (ED) settings outside of Canada. METHODS: Demographic and clinical information, rapid D-dimer testing, and venous ultrasound imaging were obtained among patients presenting with clinically suspected venous thrombosis at a university-affiliated ED. A diagnosis of deep venous thrombosis (DVT) was made based on venous ultrasound test results or objectively documented venous thromboembolism during a 12-week follow-up period. The probability of venous thrombosis was calculated using the Canadian clinical probability model. RESULTS: Among 102 patients, 17 (17%) were diagnosed as having venous thrombosis initially or during the three-month follow-up period. The frequency of venous thrombosis among patients categorized as having high probability was 10 of 17 [59%, 95% confidence interval (95% CI) = 35% to 82%], 6 of 44 (14%, 95% CI = 4% to 24%) with intermediate probability, and 1 of 41 (2%, 95% CI = 0.1% to 11%) with low probability. This compares with respective values of 49%, 14%, and 3%, reported by Canadian researchers in an ED study. Forty-one of 102 (40%) patients had an alternate diagnosis as likely or more likely than venous thrombosis, but only three (7%, 95% CI = 2% to 18%) of these had venous thrombosis. CONCLUSIONS: Use of the Canadian probability model for DVT in this ED resulted in effective risk stratification, comparable to previously published results.


Asunto(s)
Modelos Estadísticos , Probabilidad , Trombosis de la Vena/diagnóstico , Adulto , Anciano , Pruebas de Aglutinación/normas , Antifibrinolíticos , Canadá , Femenino , Vena Femoral/diagnóstico por imagen , Productos de Degradación de Fibrina-Fibrinógeno , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Evaluación de Procesos y Resultados en Atención de Salud , Valor Predictivo de las Pruebas , Estudios Prospectivos , Ultrasonografía , Trombosis de la Vena/diagnóstico por imagen
18.
J Emerg Med ; 22(2): 133-7, 2002 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-11858916

RESUMEN

The purpose of this study was to evaluate the efficacy of heliox-driven continuous nebulizers in the management of moderate to severe asthma exacerbations in the Emergency Department (ED). The trial was a prospective, randomized, double-blind, controlled trial in a university Emergency Department (volume 65,000 patients/year) of patients 18-55 years of age with acute asthma exacerbations. Patients were placed on continuous nebulizers driven by 70:30 heliox or air with 30% O(2). Respiratory rate, peak expiratory flow rate (PEFR), forced expiratory volume at 1 s (FEV1), and Borg dyspnea scale were measured at 0 and 2 h. Disposition and patient satisfaction were also assessed. A total of 36 patients completed the study (18 heliox, 18 air). There was no difference between groups in baseline variables. There was significant interval improvement within both groups at 2 h in PEFR, FEV1, Borg, and respiratory rate. There was no significant difference between heliox 70:30 and air/oxygen in PEFR [mean between-group improvement difference 17 liters/min, 95% confidence interval (CI) -20-51], FEV1 (0.03 liters/sec, 95% CI -0.22-0.30), or respiratory rate (mean between-group improvement difference 0.5, 95% CI -2.7-3.8). There was a significant improvement in the patients' perceived dyspnea as measured by the Borg dyspnea scale at 2 h in the heliox group (1.6, 95% CI 0.3-3.0). In this trial of patients with moderate-severe asthma exacerbation, heliox-driven continuous nebulizers failed to demonstrate an improvement in respiratory rate, oxygen saturation, PEFR, or FEV1 at 2 h. However, there was a significant improvement in the patients' perceived dyspnea on heliox over air/oxygen measured by the Borg dyspnea scale.


Asunto(s)
Asma/terapia , Helio/administración & dosificación , Nebulizadores y Vaporizadores , Oxígeno/administración & dosificación , Adolescente , Adulto , Método Doble Ciego , Femenino , Volumen Espiratorio Forzado , Humanos , Hipoxia/fisiopatología , Masculino , Persona de Mediana Edad , Ápice del Flujo Espiratorio , Estudios Prospectivos , Resultado del Tratamiento
19.
J Emerg Med ; 23(2): 161-4, 2002 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-12359284

RESUMEN

We report on a 61-year-old woman in whom cardiopulmonary resuscitation (CPR) was unsuccessful. While the patient was initially resuscitated from the primary cardiac arrest, with evidence of neurologic recovery, she ultimately succumbed to injuries resulting directly from closed-chest CPR. Autopsy revealed multiple rib fractures, a sternal fracture, pulmonary laceration, and cardiac rupture. In a patient with deteriorating vital signs following successful closed-chest CPR, such injuries should be considered.


Asunto(s)
Reanimación Cardiopulmonar/efectos adversos , Fracturas Cerradas/etiología , Paro Cardíaco/terapia , Lesiones Cardíacas/etiología , Ventrículos Cardíacos/lesiones , Laceraciones/etiología , Lesión Pulmonar , Fracturas de las Costillas/etiología , Esternón/lesiones , Resultado Fatal , Femenino , Humanos , Persona de Mediana Edad
20.
J Emerg Med ; 24(2): 151-6, 2003 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-12609644

RESUMEN

We describe the prevalence, primary indications and immediate complications of emergency cricothyrotomy (cric) techniques, in a single institution's Emergency Department (ED) and associated air-medical transport service. This is a retrospective review at an academic, level-one trauma center with an annual ED census of 65,000 and an associated air-medical transport service (AMTS). All patients undergoing cric in the field or in the ED between July 1995 and June 2000 were included. Expert reviewers from Emergency Medicine, Trauma Surgery and the AMTS prospectively defined the complication criteria. All charts with a possible complication underwent a blinded evaluation by reviewers representing each of the three clinical services. Descriptive statistics were used to summarize the data. Fifty crics were performed over 5 years. Seventy-six percent of crics were performed in trauma patients. The prevalence of cric in patients requiring airway management in the ED was 1.1% (95% CI, 0.7-1.6) and 10.9% (95% CI, 6.9-16.1) in the field by the AMTS. The prevalence of complications was 14% (95% CI, 4-32.6) in ED patients and 54.5% (95% CI, 32-75.6) for prehospital patients. The overall inter-rater agreement for complication rate was excellent (kappa =.87). Overall, 77% of crics were performed using the rapid four-step technique (RFST). There were no reports of complications associated with the RFST when performed in the ED. Non-RFST crics in the ED had an associated complication rate of 25% (95% CI, 2.8-60). Emergency cricothyrotomy was performed in approximately 1% of all emergency airway cases in the ED and at a higher rate by the AMTS. The most frequent indications were trauma related. Additionally, the RFST was the most commonly used technique for cric at this institution. The complication rate of cric was significantly higher in the prehospital environment than in the ED.


Asunto(s)
Cartílago Cricoides/cirugía , Cartílago Tiroides/cirugía , Traqueotomía/estadística & datos numéricos , Servicios Médicos de Urgencia , Servicio de Urgencia en Hospital , Femenino , Humanos , Masculino , Complicaciones Posoperatorias/epidemiología , Prevalencia , Estudios Retrospectivos , Traqueotomía/efectos adversos
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