[Reporting a cluster of lymphohaematopoietic cancers and management of the communication process with the community: the experience of a Local health Authority in Tuscany, Italy]. / Segnalazione di un cluster di neoplasie emolinfopoietiche e gestione del processo di comunicazione con la cittadinanza: l'esperienza di una Asl toscana.

In 2008, some general practitioners (GPs) in the area of Empoli (Tuscany Region, Central Italy), reported to the Local Health Authority (LHA), an unusually high frequency of leukemia deaths among their patients residing in a one of the municipalities of the area. The LHA decided to carry out an epidemiological investigation. An interdepartmental working group was set up, led by the Department of Prevention of the LHA, and made up of representatives of the Institute for Study, Prevention and Cancer Network (ISPRO, Florence), the G. Monasterio Foundation/ Institute of Clinical Physiology of the National Council for Research (CNR) of Pisa, the University of Pisa, the Regional Environmental Protection Agency and community members. Several epidemiological analyses were carried out (namely incidence and mortality analysis, assessment of the residential history of all cases and micro-geographical incidence evaluation, assessment and quantification of local environmental pressures, evaluation of congenital abnormalities). The investigation took over two years to be completed. The work agenda was shared with community members, who contributed to decision-making, study design and the communication plan. Thanks to the interaction with community members, researchers had the chance to become aware of their information needs and of local knowledge concerning the research issues. The final report was published online and presented to citizens in several public meetings. Direct involvement of the local community during project development was found to be useful to reduce the perceived distance between public authorities and the local population, as highlighted in the guidelines on cancer cluster investigations.

Smoke-Free Homes and Youth Smoking Behavior in Italy: Findings From the SIDRIAT Longitudinal Study.

INTRODUCTION: Few studies have explored whether smoke-free homes (SFH) can promote reductions of smoking onset in children, particularly in households with smoking parents. The aim of this study was to determine whether youths living in SFH were less likely to progress to smoking. METHODS: We conducted a longitudinal, 11-year, two-wave study on 778 children aged 6-7 years and 985 adolescents aged 13-14 in 2002. At baseline, youths were asked whether or not adults smoked at home (SFH); at follow-up, in 2012-2014, whether a household smoking ban (HSB) had been implemented during the course of the study. Logistic regression was used to investigate SFH effects on youth smoking behaviors. RESULTS: Sixty-nine percent of children and 54% of adolescents reported SFH at baseline; 80% of children and 71% of adolescents reported HSB at follow-up. Youths living in non-SFH at baseline were twice as likely to become established smokers at follow-up compared with those living in SFH (children + adolescents: odds ratio [OR] = 1.99; 95% confidence interval [CI] = 1.39-2.94; adolescents: OR = 2.15; 95% CI = 1.36-3.42; children: OR = 1.69; 95% CI = 0.80-3.56), either for youths living with nonsmoking parents at baseline and follow-up (OR for both children and adolescents = 3.06; 95% CI = 1.70-5.51) or for youths with ≥1 smoking parent at baseline and follow-up (OR = 2.12, 95% CI = 1.01-4.46). The effect was greater in youths living in the worst situation (non-SFH at baseline + non-HSB at follow-up) compared with those in the best situation (SFH at baseline + HSB at follow-up; children: OR = 3.20; 95% CI = 1.10-9.35; adolescents: OR = 5.41; 95% CI = 2.66-10.97). CONCLUSIONS: Household smoke-free policies had a significant impact in protecting youths from becoming established smokers. IMPLICATIONS: The results of the SIDRIAT longitudinal study showed that youths living in homes where people smoked at baseline were twice as likely to become established smokers 11 years later at follow-up, compared with youths living in SFH. The lower number of established smokers among youths living in SFH at baseline was recorded not only in households with nonsmoking parents but also in those with smoking parents. Implementing a home smoking ban is recommended in all households. Living in homes with no ban may be a risk factor for smoking initiation, which is independent of having smoking parents.

[Definition and adoption of a building code based on biological and ecological sustainability in the Local Health Authority 11 of Empoli (Tuscany Region, Central Italy): strengths and areas for improvement]. / Definizione e diffusione di un regolamento per l'edilizia bio-eco sostenibile nei comuni dell'ASL 11 di Empoli: punti di forza e criticità.

Built environment is an important social determinant of health, but nowadays local health authorities (LHAs) have lost their competences in the issuing of building permits, especially since a new legislation introduced the possibility of personal declaration of conformity. They are also usually excluded from the urban planning process. At the same time, in recent years construction of buildings has been developed with insufficient regard to environmental health requirements, proper exposure to sunlight and winds, comfort, building materials, consumption of resources, and waste production. To deal with these issues, an interdepartmental working group was set up under the direction of the Department of Prevention of the LHA of Empoli (Tuscany Region, Central Italy), with members of the Regional Environmental Protection Agency, along with experts of the 15 Municipalities included in the LHA territory and members of other local institutions. The objective of the Working Group was to define and propose as mandatory a set of rules for local governments aimed at regulating construction activities according to criteria of environmental sustainability, eco-efficiency, comfort, and healthiness of living areas, at the same time encouraging the responsible use of natural resources, the reduction of energy consumption and the use of renewable energy sources in order to place environmental safety and health at the heart of all building activities. Experts of six Municipalities joined the working group and the regulation framework was adopted (and made legally binding) in 8 out of 15 Municipalities, with an almost complete overlap with participation in the working group. The active participation of experts, whose work consists in examining municipal building, permits, and declarations, has therefore marked the difference in the transition from theory to practice. The level of know-how attained by the participants and their motivation and enthusiasm have been so relevant in the whole project that we think this procedure could be successfully used in other fields of inter-institutional activities.

[Italian Society of Hygiene (SItI) recommendations for a healthy, safe and sustainable housing]. / Documento d'indirizzo della Società italiana di igiene (SItI) per una casa sana, sicura e sostenibile.

As part of the strategies to promote health in urban areas, the Italian Society of Hygiene (SItI) has updated its recommendations for healthy, safe and sustainable housing. They were issued by an ad hoc SitI working group on the basis of the best available evidence retrieved from a review of the scientific and legal literature on the topic and in line with World Health Organisation, European Union, and other international bodies statements. SItI document includes recommendations for environmental comfort, mental and social wellbeing, environmental protection as well as the safety of people who dwell houses. In addition to typical issues (such as relative humidity parameters, ventilation, and safety rules), SItI recommendations address innovative aspects such as building compatibility between different functions, building safety management and green area design. In this context, SItI recommendations emphasise the need of a strengthened interaction between architects and public health experts to ensure the complete wellbeing in houses where people spend more than 50% of their lives.

[Sustainability and hygiene of building: future perspectives]. / La sostenibilità dell'ambiente costruito: attualità e prospettive.

OBJECTIVES: Multiple factors influence individuals' health status. Their impact is difficult to quantify as it is their interaction. Aim of the current work is to develop guidelines to support designers to promote health in the residential environment and to apply them through an evaluation system to certify the level of health performance. DESIGN: Politecnico di Milano, in collaboration with the Local Health Authorities of Milan and Empoli through analysis of needs performance and numerous multidisciplinary meetings, has produced a design guide (Healthy Design Guide - HeDe) and an evaluation system to certify the level of health performance. This system was tested on the Milan metropolitan area. SETTING: The experiment was carried out on a sample of 30 private residences, with an overall floor area ranging between 90 and 150 square meters, new or recently renovated. RESULTS: The tool works but at the same time it also shows that too often design choices are made for aesthetic or economic reasons rather than a real need for health and wellness. CONCLUSIONS: It is becoming increasingly important to strengthen synergies and multidisciplinary collaborations to achieve shared performance indications and to make a systematic review of the regulatory tools to protect public health.

Effects of pet exposure in the first year of life on respiratory and allergic symptoms in 7-yr-old children. The SIDRIA-2 study.

The effects of pet exposure on the development of respiratory symptoms have recently been the matter of vivid discussion. Our objective was to determine the effects of exposure to cat or dog in the first year of life on subsequent respiratory/allergic symptoms in children in a large Italian multicentre study. As part of the SIDRIA-2 Study (Studi Italiani sui Disturbi Respiratori dell'Infanzia e l'Ambiente 2002), the parents of 20016 children (median age 7 yr) provided information on indoor exposures at different times in life and respiratory/allergic symptoms through questionnaires. Logistic regression analyses were performed taking into account cat or dog exposure at different times in life and adjusting for the presence of the other pet, mould exposure, gender, age, parental education, maternal smoking during the first year of life, current passive smoking, family history of asthma/rhinitis/eczema and other potential confounders. Neither significant effects of dog exposure in the first year of life nor in other periods were found on respiratory/allergic symptoms after adjusting for the other covariates. Cat exposure in the first year of life was significantly and independently associated with current wheezing [OR (95% CI) 1.88 (1.33-2.68), p < 0.001] and current asthma [1.74 (1.10-2.78), p < 0.05] and border-line associated with current rhinoconjunctivitis [1.43 (0.97-2.11), p = 0.07]. No other effects of cat exposure were found on respiratory/allergic symptoms. Cat, but not dog, exposure in the first year of life is an independent risk factor for current wheezing, current asthma and current rhinoconjunctivitis at the age of 7.

[Effects of indoor exposures on respiratory and allergic disorders]. / Effetti delle esposizioni indoor su sintomi respiratori e allergici.

Several studies have shown that indoor pollution increases the risk for chronic pulmonary diseases and acute respiratory symptoms in children/adolescents. Some associations have been confirmed by studies. Other relations are still unclear, such as those regarding dog and cat ownership. In this study we assessed the relationships of the exposure to mould and dog/cat ownership with respiratory/allergic symptoms/diagnoses, such as wheezing, asthma, rhinoconjunctivitis, eczema, and cough/phlegm in 20,016 children (6-7 yrs old) and 13,266 adolescents (13-14 yrs old) from 12 Italian areas. Early mould exposure (in the first year of life) was positively related to all considered symptoms/diagnoses (significantly for wheezing, asthma, rhinoconjunctivitis in both children and adolescents, and for cough/phlegm among children); current exposure (in the last year) was a significant risk factor for wheeze, among children. In the latter, dog exposure only in the first year of life increased the risk for wheezing and cough/phlegm, whereas the presence of a dog lifetime seemed a protective factor (though not significant) for all symptoms/diagnoses; negative relations (but not significant) suggested a protective effect by the cat for asthma, independently of exposure period. Among adolescents, the presence of a dog both lifetime and only in the first year of life was significantly related to cough/phlegm; except for rhino-conjunctivitis, all symptoms/diagnoses were negatively related to the presence of a cat lifetime (though not significantly). In conclusion, our results confirmed the effects of mould exposure, especially when it occurs early, on the prevalence of respiratory disorders such as asthma, rhinitis and cough in the pediatric age. The complex relations between keeping a dog or cat at home and respiratory/allergic symptoms/diseases in childhood warrants further studies.

[Changes in social characteristics and risk factors for asthma and allergies among children and adolescents in Italy]. / I cambiamenti delle caratteristiche sociali e dei fattori di rischio per l'asma e le allergie tra i bambini e gli adolescenti italiani.

One of the main objectives of SIDRIA-2 study was to evaluate the possible changes in the occurrence of social characteristics and risk factors for asthma and allergies in childhood, comparing the data obtained in 2002 to those collected in 1994-1995. A positive change in socio-economic characteristics of the childrens' and adolescents' families was generally observed. The levels of exposure to outdoor (traffic) and indoor (passive smoking) pollutants are still high, although a decreasing trend in parents' smoking habits is evident.

Impact of National Smoke-Free Legislation on Educational Disparities in Smoke-Free Homes: Findings from the SIDRIAT Longitudinal Study.

Families with lower socioeconomic status are less likely to adopt household smoking bans (HSB). The aim of this study was to determine whether socioeconomic disparities in HSB prevalence in Italy decreased 7-9 years after the introduction of the Italian ban on smoking in public places. A longitudinal, 12-year, two-wave study was conducted on a sample of 3091 youths aged 6-14 years in 2002; 1763 (57%) were re-interviewed in 2012-2014. A Poisson regression with a robust error variance was used to assess the association between socioeconomic disparities and HSB prevalence. The adoption of HSBs significantly increased from 60% in 2002 to 75% in 2012-2014, with the increase recorded in youths with ≥1 smoking parent only (from 22% at baseline to 46% at follow-up). The presence of HSBs at baseline was more likely in families with ≥1 graduate parent compared to those with no graduate parents (prevalence ratio (PR) = 1.34, 95% confidence interval (CI) = 1.15-1.57), either in families with ≥1 smoking parent (PR = 1.36, 95% CI = 1.17-1.58) or in families with non-smoking parents (PR = 1.61, 95% CI = 1.01-2.56). Conversely, at follow-up socioeconomic disparities dropped since families with no graduate parents were 1.5-fold more likely to introduce a HSB between the two waves. The Italian ban on smoking in public places may have increased the adoption of smoke-free homes in families with smoking and non-graduate parents, causing the drop of the socioeconomic gap in smoke-free homes.

Changes in prevalence of asthma and allergies among children and adolescents in Italy: 1994-2002.

BACKGROUND: Several studies conducted during the 1990s indicated an increase in the prevalence of symptoms of asthma; more recent investigations suggest that the trend is stabilizing or may even be reversing. OBJECTIVE: We compared 2 cross-sectional surveys conducted in 1994 and 2002 in 8 areas in northern and central Italy, to evaluate prevalence changes for asthma, allergic rhinitis, and eczema. METHODS: The International Study of Asthma and Allergies in Childhood methods and questionnaires were used to investigate 6- to 7-year-old children (16,115 and 11,287 questionnaires completed by parents in 1994-1995 and 2002, respectively) and 13- to 14-year-old adolescents (19,723 and 10,267 questionnaires completed by adolescents in 1994-1995 and 2002, respectively). In each phase, the overall response rate was >90%. Prevalence changes were calculated as the absolute difference between the prevalence recorded on the 2 occasions. RESULTS: The prevalence of wheeze (past 12 months) increased slightly among children (change: 0.8%; 95% confidence interval [CI]: 0.0% to 1.6%) and was rather stable among adolescents. Symptoms of allergic rhinitis (children: change: 5.2%; 95% CI: 4.0% to 6.4%; adolescents: change: 4.1%; 95% CI: 1.9% to 6.3%) and symptoms of atopic eczema (children: change: 4.4%; 95% CI: 3.6% to 5.2%; adolescents: change: 2.1%; 95% CI: 1.2% to 3.0%) increased clearly in both age groups. There was some heterogeneity across the centers among adolescents, especially for allergic rhinitis, with larger increases seen in the 3 metropolitan areas. The changes observed paralleled profound family changes, ie, better parental education, higher rates of maternal employment, and lower rates of exposure to parental smoke. These factors, however, do not explain all of the observed changes in prevalence. CONCLUSIONS: The results indicate that the epidemiologic features of asthma and allergies in Italy are changing rapidly, although the causes are still uncertain.